日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural Basis of the Differential Binding of Engineered Knottins to Integrins αVβ3 and α5β1

工程化 Knottin 与整合素 αVβ3 和 α5β1 差异性结合的结构基础

Johannes F Van Agthoven ,Hengameh Shams ,Frank V Cochran ,José L Alonso ,James R Kintzing ,Kiavash Garakani ,Brian D Adair ,Jian-Ping Xiong ,Mohammad R K Mofrad ,Jennifer R Cochran ,M Amin Arnaout

Plasma Rich in Growth Factors (PRGF) Disrupt the Blood-Brain Barrier Integrity and Elevate Amyloid Pathology in the Brains of 5XFAD Mice

富含生长因子 (PRGF) 的血浆会破坏血脑屏障的完整性,并增加 5XFAD 小鼠脑中的淀粉样蛋白病理

Quoc-Viet Duong, Margia L Kintzing, William E Kintzing, Ihab M Abdallah, Andrew D Brannen, Amal Kaddoumi

Emerging Strategies for Developing Next-Generation Protein Therapeutics for Cancer Treatment

开发用于癌症治疗的下一代蛋白质疗法的新兴策略

Kintzing, James R; Filsinger Interrante, Maria V; Cochran, Jennifer R

Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation

整合素靶向Knottin肽-药物偶联物是肿瘤细胞增殖的强效抑制剂

Cox, Nick; Kintzing, James R; Smith, Mark; Grant, Gerald A; Cochran, Jennifer R

Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis

利用无细胞蛋白质合成产生的整合素结合 Knottin-Fc-MMAF 结合物进行靶向药物输送

Nicolas V Currier, Shelley E Ackerman, James R Kintzing, Rishard Chen, Maria Filsinger Interrante, Alexander Steiner, Aaron K Sato, Jennifer R Cochran

A Bioengineered Peptide that Localizes to and Illuminates Medulloblastoma: A New Tool with Potential for Fluorescence-Guided Surgical Resection

一种可定位并照亮髓母细胞瘤的生物工程肽:一种具有荧光引导手术切除潜力的新工具

Ackerman, Shelley E; Wilson, Christy M; Kahn, Suzana A; Kintzing, James R; Jindal, Darren A; Cheshier, Samuel H; Grant, Gerald A; Cochran, Jennifer R

Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo

平衡聚乙二醇化siRNA多聚体的阳离子和疏水含量可增强其内吞体逃逸、稳定性、血液循环时间和体内生物活性。

Nelson, Christopher E; Kintzing, James R; Hanna, Ann; Shannon, Joshua M; Gupta, Mukesh K; Duvall, Craig L