日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Atom-level enzyme active site scaffolding using RFdiffusion2

利用 RFdiffusion2 进行原子级酶活性位点支架构建

Ahern, Woody; Yim, Jason; Tischer, Doug; Salike, Saman; Woodbury, Seth M; Kim, Donghyo; Kalvet, Indrek; Kipnis, Yakov; Coventry, Brian; Altae-Tran, Han Raut; Bauer, Magnus S; Barzilay, Regina; Jaakkola, Tommi S; Krishna, Rohith; Baker, David

Computational design of serine hydrolases

丝氨酸水解酶的计算设计

Lauko, Anna; Pellock, Samuel J; Sumida, Kiera H; Anishchenko, Ivan; Juergens, David; Ahern, Woody; Jeung, Jihun; Shida, Alexander F; Hunt, Andrew; Kalvet, Indrek; Norn, Christoffer; Humphreys, Ian R; Jamieson, Cooper; Krishna, Rohith; Kipnis, Yakov; Kang, Alex; Brackenbrough, Evans; Bera, Asim K; Sankaran, Banumathi; Houk, K N; Baker, David

Modeling protein-small molecule conformational ensembles with PLACER

利用PLACER对蛋白质-小分子构象集合进行建模

Anishchenko, Ivan; Kipnis, Yakov; Kalvet, Indrek; Zhou, Guangfeng; Krishna, Rohith; Pellock, Samuel J; Lauko, Anna; Lee, Gyu Rie; An, Linna; Dauparas, Justas; DiMaio, Frank; Baker, David

Improving Protein Expression, Stability, and Function with ProteinMPNN

利用 ProteinMPNN 改善蛋白质表达、稳定性和功能

Sumida, Kiera H; Núñez-Franco, Reyes; Kalvet, Indrek; Pellock, Samuel J; Wicky, Basile I M; Milles, Lukas F; Dauparas, Justas; Wang, Jue; Kipnis, Yakov; Jameson, Noel; Kang, Alex; De La Cruz, Joshmyn; Sankaran, Banumathi; Bera, Asim K; Jiménez-Osés, Gonzalo; Baker, David

De novo design of luciferases using deep learning

利用深度学习从头设计荧光素酶

Yeh, Andy Hsien-Wei; Norn, Christoffer; Kipnis, Yakov; Tischer, Doug; Pellock, Samuel J; Evans, Declan; Ma, Pengchen; Lee, Gyu Rie; Zhang, Jason Z; Anishchenko, Ivan; Coventry, Brian; Cao, Longxing; Dauparas, Justas; Halabiya, Samer; DeWitt, Michelle; Carter, Lauren; Houk, K N; Baker, David

De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

从头设计高选择性整合素αvβ6和αvβ8小蛋白抑制剂

Roy, Anindya; Shi, Lei; Chang, Ashley; Dong, Xianchi; Fernandez, Andres; Kraft, John C; Li, Jing; Le, Viet Q; Winegar, Rebecca Viazzo; Cherf, Gerald Maxwell; Slocum, Dean; Daniel Poulson, P; Casper, Garrett E; Vallecillo-Zúniga, Mary L; Valdoz, Jonard Corpuz; Miranda, Marcos C; Bai, Hua; Kipnis, Yakov; Olshefsky, Audrey; Priya, Tanu; Carter, Lauren; Ravichandran, Rashmi; Chow, Cameron M; Johnson, Max R; Cheng, Suna; Smith, McKaela; Overed-Sayer, Catherine; Finch, Donna K; Lowe, David; Bera, Asim K; Matute-Bello, Gustavo; Birkland, Timothy P; DiMaio, Frank; Raghu, Ganesh; Cochran, Jennifer R; Stewart, Lance J; Campbell, Melody G; Van Ry, Pam M; Springer, Timothy; Baker, David

Design and optimization of enzymatic activity in a de novo β-barrel scaffold

从头构建的β桶状支架中酶活性的设计和优化

Kipnis, Yakov; Chaib, Anissa Ouald; Vorobieva, Anastassia A; Cai, Guangyang; Reggiano, Gabriella; Basanta, Benjamin; Kumar, Eshan; Mittl, Peer R E; Hilvert, Donald; Baker, David

A computational method for design of connected catalytic networks in proteins

一种用于设计蛋白质中连通催化网络的计算方法

Weitzner, Brian D; Kipnis, Yakov; Daniel, A Gerard; Hilvert, Donald; Baker, David

De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters

从头设计的酶作为小分子调控的荧光成像标签和荧光报告分子

Liu, Yu; Zhang, Xin; Tan, Yun Lei; Bhabha, Gira; Ekiert, Damian C; Kipnis, Yakov; Bjelic, Sinisa; Baker, David; Kelly, Jeffery W

Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts

利用小分子探针定量细胞内特定蛋白质的功能部分,同时最大限度地减少折叠平衡的偏移

Liu, Yu; Tan, Yun Lei; Zhang, Xin; Bhabha, Gira; Ekiert, Damian C; Genereux, Joseph C; Cho, Younhee; Kipnis, Yakov; Bjelic, Sinisa; Baker, David; Kelly, Jeffery W