Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment.
SNAP-25 在 Ser187 位点的磷酸化在被 A 型肉毒杆菌神经毒素切割后增强,从而促进了所得片段的显性负效应。
期刊:PLoS Pathogens
影响因子:4.9
doi:10.1371/journal.ppat.1013604
Koc Dilara, Ezgin Sena, Kavakli Ebru, Kota Krishna P, Sen Edanur, Mahone Christopher, Palko Mary Ellen, Cazares Lisa H, Can Tolga, Tessarollo Lino, Bavari Sina, Marion Antoine, Kiris Erkan