日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd

EGFR 抑制可增强 HER3 抗体-药物偶联物 HER3-DXd 的细胞摄取和抗肿瘤活性

Heidi M Haikala, Timothy Lopez, Jens Köhler, Pinar O Eser, Man Xu, Qing Zeng, Tyler J Teceno, Kenneth Ngo, Yutong Zhao, Elena V Ivanova, Arrien A Bertram, Brittaney A Leeper, Emily S Chambers, Anika E Adeni, Luke J Taus, Mari Kuraguchi, Paul T Kirschmeier, Channing Yu, Yoshinobu Shiose, Yasuki Kamai

Combination of Type I and Type II MET Tyrosine Kinase Inhibitors as Therapeutic Approach to Prevent Resistance

联合使用 I 型和 II 型 MET 酪氨酸激酶抑制剂作为预防耐药性的治疗方法

Magda Bahcall, Cloud P Paweletz, Yanan Kuang, Luke J Taus, Taebo Sim, Nam Doo Kim, Kshiti H Dholakia, Christie J Lau, Prafulla C Gokhale, Pratik R Chopade, Fangxin Hong, Zihan Wei, Jens Köhler, Paul T Kirschmeier, Jiannan Guo, Sujuan Guo, Stephen Wang, Pasi A Jänne

Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade

动态单细胞 RNA 测序识别 PD-1 阻断后的免疫治疗持久细胞

Kartik Sehgal, Andrew Portell, Elena V Ivanova, Patrick H Lizotte, Navin R Mahadevan, Jonathan R Greene, Amir Vajdi, Carino Gurjao, Tyler Teceno, Luke J Taus, Tran C Thai, Shunsuke Kitajima, Derek Liu, Tetsuo Tani, Moataz Noureddine, Christie J Lau, Paul T Kirschmeier, David Liu, Marios Giannakis, R

Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

同时使用地塞米松会限制免疫检查点阻断疗法在胶质母细胞瘤中的临床疗效

Iorgulescu, J Bryan; Gokhale, Prafulla C; Speranza, Maria C; Eschle, Benjamin K; Poitras, Michael J; Wilkens, Margaret K; Soroko, Kara M; Chhoeu, Chhayheng; Knott, Aine; Gao, Yan; Lim-Fat, Mary Jane; Baker, Gregory J; Bonal, Dennis M; Nguyen, Quang-Dé; Grant, Gareth R L; Ligon, Keith L; Sorger, Peter K; Chiocca, E Antonio; Anderson, Ana C; Kirschmeier, Paul T; Sharpe, Arlene H; Freeman, Gordon J; Reardon, David A

Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations

从不吸烟/轻度吸烟者临床诊断的小细胞肺癌的基因组和病理异质性可确定治疗上可针对性的改变

Atsuko Ogino, Jihyun Choi, Mika Lin, Margaret K Wilkens, Antonio Calles, Man Xu, Anika E Adeni, Emily S Chambers, Marzia Capelletti, Mohit Butaney, Nathanael S Gray, Prafulla C Gokhale, Sangeetha Palakurthi, Paul Kirschmeier, Geoffrey R Oxnard, Lynette M Sholl, Pasi A Jänne

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

KRAS驱动的肺癌中LKB1缺失与STING抑制相关

Shunsuke Kitajima,Elena Ivanova,Sujuan Guo,Ryohei Yoshida,Marco Campisi,Shriram K Sundararaman,Shoichiro Tange,Yoichiro Mitsuishi,Tran C Thai,Sayuri Masuda,Brandon P Piel,Lynette M Sholl,Paul T Kirschmeier,Cloud P Paweletz,Hideo Watanabe,Mamiko Yajima,David A Barbie

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

抑制髓系细胞精氨酸酶活性可通过激活抗肿瘤免疫在非小细胞肺癌小鼠模型中产生治疗反应

Juan J Miret ,Paul Kirschmeier ,Shohei Koyama ,Mingrui Zhu ,Yvonne Y Li ,Yujiro Naito ,Min Wu ,Venkat S Malladi ,Wei Huang ,William Walker ,Sangeetha Palakurthi ,Glenn Dranoff ,Peter S Hammerman ,Chad V Pecot ,Kwok-Kin Wong ,Esra A Akbay

The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition

CHK1 抑制剂 Prexasertib 在高级别浆液性卵巢癌模型中表现出单一疗法活性,并对 PARP 抑制敏感

Kalindi Parmar, Bose S Kochupurakkal, Jean-Bernard Lazaro, Zhigang C Wang, Sangeetha Palakurthi, Paul T Kirschmeier, Chunyu Yang, Larissa A Sambel, Anniina Färkkilä, Elizaveta Reznichenko, Hunter D Reavis, Connor E Dunn, Lee Zou, Khanh T Do, Panagiotis A Konstantinopoulos, Ursula A Matulonis, Joyce

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

克服对KRAS下游双重先天免疫和MEK抑制的耐药性

Shunsuke Kitajima ,Hajime Asahina ,Ting Chen ,Sujuan Guo ,Laura Gutierrez Quiceno ,Jillian D Cavanaugh ,Ashley A Merlino ,Shoichiro Tange ,Hideki Terai ,Jong Wook Kim ,Xiaoen Wang ,Shan Zhou ,Man Xu ,Stephen Wang ,Zehua Zhu ,Tran C Thai ,Chiaki Takahashi ,Yujin Wang ,Richard Neve ,Susanna Stinson ,Pablo Tamayo ,Hideo Watanabe ,Paul T Kirschmeier ,Kwok-Kin Wong ,David A Barbie

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

利用类器官肿瘤球体进行PD-1阻断的体外分析

Russell W Jenkins,Amir R Aref,Patrick H Lizotte,Elena Ivanova,Susanna Stinson,Chensheng W Zhou,Michaela Bowden,Jiehui Deng,Hongye Liu ,Diana Miao,Meng Xiao He ,William Walker,Gao Zhang,Tian Tian,Chaoran Cheng,Zhi Wei,Sangeetha Palakurthi,Mark Bittinger,Hans Vitzthum,Jong Wook Kim,Ashley Merlino,Max Quinn,Chandrasekar Venkataramani,Joshua A Kaplan,Andrew Portell,Prafulla C Gokhale,Bart Phillips,Alicia Smart,Asaf Rotem,Robert E Jones,Lauren Keogh,Maria Anguiano,Lance Stapleton,Zhiheng Jia,Michal Barzily-Rokni,Israel Cañadas,Tran C Thai,Marc R Hammond,Raven Vlahos,Eric S Wang,Hua Zhang,Shuai Li,Glenn J Hanna,Wei Huang,Mai P Hoang,Adriano Piris,Jean-Pierre Eliane,Anat O Stemmer-Rachamimov,Lisa Cameron,Mei-Ju Su,Parin Shah,Benjamin Izar,Manisha Thakuria,Nicole R LeBoeuf,Guilherme Rabinowits,Viswanath Gunda,Sareh Parangi,James M Cleary,Brian C Miller,Shunsuke Kitajima,Rohit Thummalapalli,Benchun Miao,Thanh U Barbie,Vivek Sivathanu,Joshua Wong,William G Richards , Raphael Bueno , Charles H Yoon,Juan Miret,Meenhard Herlyn,Levi A Garraway,Eliezer M Van Allen,Gordon J Freeman,Paul T Kirschmeier,Jochen H Lorch,Patrick A Ott,F Stephen Hodi,Keith T Flaherty,Roger D Kamm  ,Genevieve M Boland,Kwok-Kin Wong,David Dornan , Cloud Peter Paweletz ,David A Barbie