日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

First-In-Human Safety, Pharmacokinetics, and Pharmacodynamics of VENT-02 Freebase, a CNS-Penetrant NLRP3 Inhibitor

VENT-02 游离碱（一种可穿透血脑屏障的 NLRP3 抑制剂）的首次人体安全性、药代动力学和药效学研究

期刊:Cts-Clinical and Translational Science
影响因子:2.8
doi:10.1111/cts.70578
Smidt, Lisanne C A; Moerland, Matthijs; Jansen, Manon A A; Kremer, Philip H C; Sille, Alexandra A J; Strugala, Pamela K; Klaassen, Erica S; Auger, Anick; Jananji, Silvana; Faidi, Rania; Pike, Kelly A; Warner, Loraine; Matta, Andre; Valencia, Xavier; Spiegelstein, Ofer
NLRP3
Human
神经科学
LRP3
血脑屏障
发表日期：2026
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POLB 001, a p38 MAPK inhibitor, decreases local and systemic inflammatory responses following in vivo LPS administration in healthy volunteers: a randomised, double-blind, placebo-controlled study

POLB 001（一种 p38 MAPK 抑制剂）可降低健康志愿者体内注射 LPS 后引起的局部和全身炎症反应：一项随机、双盲、安慰剂对照研究

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2025.1684307
de Bruin, Digna T; Jansen, Manon A A; Pereira, Diana R; van Schijndel, Lisa; Klaassen, Erica S; Otto, Marije E; Skillington, Jeremy; Maguire, Paula; Tremble, Liam; Bell, Alan; Maher, Laura; Mihara, Katsuhiro; Sumeray, Mark; Gilroy, Derek W; Klarenbeek, Naomi B; Moerland, Matthijs
炎症/感染
炎症
p38 MAPK
MAPK/ERK
发表日期：2025
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TMS and EEG Pharmacodynamic Effects of a Selective Sphingosine-1-Phosphate Subtype 1 Receptor Agonist on Cortical Excitability in Healthy Subjects

选择性鞘氨醇-1-磷酸亚型1受体激动剂对健康受试者皮层兴奋性的TMS和EEG药效学效应

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.3521
de Cuba, Catherine M K E; de Goede, Annika A; Klaassen, Erica S; Otto, Marije E; Doll, Robert J; Kim, Jessica; Demitrack, Mark A; Chen, Ruihua; Groeneveld, Geert Jan; Heuberger, Jules A A C
信号转导
多发性硬化症
发表日期：2025
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Safety, Pharmacokinetics, and Pharmacodynamics of a First-in-Class ClC-1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial

首个用于增强肌肉兴奋性的ClC-1抑制剂的安全性、药代动力学和药效学：I期随机对照试验

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.3516
Ruijs, Titia Q; de Cuba, Catherine M K E; Heuberger, Jules A A C; Hutchison, John; Bold, Jane; Grønnebæk, Thomas S; Jensen, Klaus G; Chin, Eva; Quiroz, Jorge A; Petersen, Thomas K; Flagstad, Peter; de Kam, Marieke L; van Esdonk, Michiel J; Klaassen, Erica; Doll, Robert J; Koopmans, Ingrid W; de Goede, Annika A; Aulin, Linda B S; Pedersen, Thomas H; Groeneveld, Geert Jan
发表日期：2025
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Biomarker-Based Pharmacological Characterization of ENX-102, a Novel α2/3/5 Subtype-Selective GABAA Receptor Positive Allo-Steric Modulator: Translational Insights from Rodent and Human Studies

基于生物标志物的新型α2/3/5亚型选择性GABAA受体正向变构调节剂ENX-102的药理学表征：来自啮齿动物和人体研究的转化启示

期刊:Cells
影响因子:5.2
doi:10.3390/cells14201575
Nettesheim, Pauline; Vadodaria, Krishna C; Vanover, Kimberly E; Borghans, Laura G J M; Arce, Estibaliz; Brubaker, William; Cunningham, Stephen; Parks, Stephanie; Serrats, Jordi; Sudarsan, Vikram; Taylor, Eve; Klaassen, Erica; Stuurman, Frederik E; Jacobs, Gabriel E
Human
发表日期：2025
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Cognitive Effects of Three β-Adrenoceptor Acting Drugs in Healthy Volunteers and Patients with Parkinson's Disease

三种β-肾上腺素受体激动剂对健康志愿者和帕金森病患者认知功能的影响

期刊:Journal of Parkinsons Disease
影响因子:5
doi:10.3233/JPD-240039
Eijsvogel, Pepijn P N M; Borghans, Laura G J M; Prins, Samantha; Moss, Laurence; van Kraaij, Sebastiaan J W; van Brummelen, Emilie; Klaassen, Erica; Martin, Renee S; Bautista, Edgar; Ford, Anthony P; Kremer, Philip H C; Groeneveld, Geert Jan; Vargas, Gabriel A
信号转导
帕金森
神经科学
免疫/内分泌
发表日期：2024
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A crossover study evaluating the sex-dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects

一项交叉研究，采用伤害性感受测试组评估睡眠剥夺对健康受试者的性别依赖性和致敏效应。

期刊:British Journal of Clinical Pharmacology
影响因子:3
doi:10.1111/bcp.15505
Hijma, Hemme; Koopmans, Ingrid; Klaassen, Erica; Doll, Robert Jan; Zuiker, Rob; Groeneveld, Geert Jan
发表日期：2023
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Identification of peripheral vascular function measures and circulating biomarkers of mitochondrial function in patients with mitochondrial disease.

线粒体疾病患者的外周血管功能指标和线粒体功能循环生物标志物的鉴定

期刊:Cts-Clinical and Translational Science
影响因子:2.8
doi:10.1111/cts.13530
van Kraaij Sebastiaan J W, Pereira Diana R, Smal Bastiaan, Summo Luciana, Konkel Anne, Lossie Janine, Busjahn Andreas, Grammatopoulos Tom N, Klaassen Erica, Fischer Robert, Schunck Wolf-Hagen, Gal Pim, Moerland Matthijs
其它
线粒体
发表日期：2023
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Central nervous system effects of TAK-653, an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole receptor (AMPAR) positive allosteric modulator in healthy volunteers

TAK-653（一种在研的α-氨基-3-羟基-5-甲基-4-异恶唑受体（AMPAR）正向变构调节剂）对健康志愿者中枢神经系统的影响

期刊:Translational Psychiatry
影响因子:6.2
doi:10.1038/s41398-022-02148-w
Dijkstra, Francis; O'Donnell, Patricio; Klaassen, Erica; Buhl, Derek; Asgharnejad, Mahnaz; Rosen, Laura; Zuiker, Rob; van Gerven, Joop; Jacobs, Gabriël
信号转导
神经科学
发表日期：2022
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First-in-human trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of STR-324, a dual enkephalinase inhibitor for pain management.

首次人体试验，旨在评估 STR-324（一种用于疼痛管理的双重脑啡肽酶抑制剂）的安全性、耐受性、药代动力学和药效学

期刊:British Journal of Clinical Pharmacology
影响因子:3
doi:10.1111/bcp.14931
Moss Laurence M, Berends Cecile L, van Brummelen Emilie M J, Kamerling Ingrid M C, Klaassen Erica S, Bergmann Kirsten, Ville Vanessa, Juarez-Perez Victor, Benichou Annie-Claude, Groeneveld Geert Jan
其它
Human
发表日期：2022
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