文献库，生知库 | 链接生命科学的每一步

日期影响因子

3-O-trans-p-coumaroyl esterification enhances the anti-inflammatory effects of tormentic acid by targeting NF-κB signaling

3-O-反式-对香豆酰酯化通过靶向NF-κB信号通路增强了苦参酸的抗炎作用

期刊:Redox Biology

影响因子:11.9

doi:10.1016/j.redox.2025.103731

Heckmann, Mara; Karlsberger, Lea; Blank-Landeshammer, Bernhard; Klanert, Gerald; Sadova, Nadiia; Stadlbauer, Verena; Sandner, Georg; Gramatte, Theresa; Kasis, Simone; Weghuber, Julian

发表日期：2025

文献求助收藏

Extracts Prepared from Feed Supplements Containing Wood Lignans Improve Intestinal Health by Strengthening Barrier Integrity and Reducing Inflammation

含有木脂素的饲料补充剂提取物可通过增强屏障完整性和减少炎症来改善肠道健康

期刊:Molecules

影响因子:4.2

doi:10.3390/molecules27196327

Mara Heckmann, Nadiia Sadova, Ivana Drotarova, Stefanie Atzmüller, Bettina Schwarzinger, Roberto Mauricio Carvalho Guedes, Paula Angelica Correia, Stefan Hirtenlehner, Christine Potthast, Gerald Klanert, Julian Weghuber

Immunology/Inflammation

发表日期：2022

文献求助收藏

Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical

人类二胺氧化酶的肝素结合基序突变允许开发一流的组胺降解生物药物

影响因子:6.4

doi:10.7554/eLife.68542

Elisabeth Gludovacz, Kornelia Schuetzenberger, Marlene Resch, Katharina Tillmann, Karin Petroczi, Markus Schosserer, Sigrid Vondra, Serhii Vakal, Gerald Klanert, Jürgen Pollheimer, Tiina A Salminen, Bernd Jilma, Nicole Borth, Thomas Boehm

发表日期：2021

文献求助收藏

A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

利用成对的gRNA，通过CRISPR/AsCpf1筛选技术，诱导中国仓鼠卵巢细胞基因组缺失。

期刊:Biotechnology Reports

doi:10.1016/j.btre.2021.e00649

Schmieder, Valerie; Novak, Neža; Dhiman, Heena; Nguyen, Ly Ngoc; Serafimova, Evgenija; Klanert, Gerald; Baumann, Martina; Kildegaard, Helene Faustrup; Borth, Nicole

细胞生物学

发表日期：2021

文献求助收藏

Systematic use of synthetic 5'-UTR RNA structures to tune protein translation improves yield and quality of complex proteins in mammalian cell factories

系统地使用合成的 5'-UTR RNA 结构来调节蛋白质翻译可提高哺乳动物细胞工厂中复杂蛋白质的产量和质量

期刊:Nucleic Acids Research

影响因子:16.6

doi:10.1093/nar/gkaa847

Peter Eisenhut, Aman Mebrahtu, Mona Moradi Barzadd, Niklas Thalén, Gerald Klanert, Marcus Weinguny, Anna Sandegren, Chao Su, Diane Hatton, Nicole Borth, Johan Rockberg

细胞生物学

发表日期：2020

文献求助收藏

Directed evolution approach to enhance efficiency and speed of outgrowth during single cell subcloning of Chinese Hamster Ovary cells

利用定向进化方法提高中国仓鼠卵巢细胞单细胞亚克隆过程中的效率和增殖速度

期刊:Computational and Structural Biotechnology Journal

影响因子:4.1

doi:10.1016/j.csbj.2020.05.020

Weinguny, Marcus; Klanert, Gerald; Eisenhut, Peter; Jonsson, Andreas; Ivansson, Daniel; Lövgren, Ann; Borth, Nicole

细胞生物学

发表日期：2020

文献求助收藏

Random epigenetic modulation of CHO cells by repeated knockdown of DNA methyltransferases increases population diversity and enables sorting of cells with higher production capacities

通过反复敲低DNA甲基转移酶，对CHO细胞进行随机表观遗传调控，可以增加细胞群体的多样性，并能够筛选出具有更高生产能力的细胞。

期刊:Biotechnology and Bioengineering

影响因子:3.6

doi:10.1002/bit.27493

Weinguny, Marcus; Eisenhut, Peter; Klanert, Gerald; Virgolini, Nikolaus; Marx, Nicolas; Jonsson, Andreas; Ivansson, Daniel; Lövgren, Ann; Borth, Nicole

细胞生物学

发表日期：2020

文献求助收藏

A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets.

在悬浮培养的中国仓鼠卵巢细胞中进行跨物种全基因组siRNA筛选，发现了新的工程靶点

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-019-45159-2

Klanert Gerald, Fernandez Daniel J, Weinguny Marcus, Eisenhut Peter, BÃ¼hler Eugen, Melcher Michael, Titus Steven A, Diendorfer Andreas B, Gludovacz Elisabeth, Jadhav Vaibhav, Xiao Su, Stern Beate, Lal Madhu, Shiloach Joseph, Borth Nicole

细胞生物学

发表日期：2019

文献求助收藏

Epigenetic regulation of gene expression in Chinese Hamster Ovary cells in response to the changing environment of a batch culture

中国仓鼠卵巢细胞在批量培养环境中基因表达的表观遗传调控

期刊:Biotechnology and Bioengineering

影响因子:3.5

doi:10.1002/bit.26891

Inmaculada Hernandez, Heena Dhiman, Gerald Klanert, Vaibhav Jadhav, Norbert Auer, Michael Hanscho, Martina Baumann, Anna Esteve-Codina, Marc Dabad, Jessica Gómez, Tyler Alioto, Angelika Merkel, Emanuele Raineri, Simon Heath, Daniel Rico, Nicole Borth

发表日期：2019

文献求助收藏

Stable overexpression of miR-17 enhances recombinant protein production of CHO cells

miR-17的稳定过表达可增强CHO细胞重组蛋白的产量。

期刊:Journal of Biotechnology

影响因子:3.9

doi:10.1016/j.jbiotec.2014.01.032

Jadhav, Vaibhav; Hackl, Matthias; Klanert, Gerald; Hernandez Bort, Juan A; Kunert, Renate; Grillari, Johannes; Borth, Nicole

细胞生物学

发表日期：2014

文献求助收藏