Klaus R相关文献与解析，生知库 | 链接生命科学的每一步

La Sala, Grégory; Kroell, Katharina B; Pincha, Mudita; Gassner, Christian; Deho, Lorenzo; Moessner, Ekkehard; Gueripel, Xavier; Borin, Nicole; Classen, Moritz; Benz, Jörg; Bujotzek, Alexander; Klein, Christian; Georges, Guy; Hugenmatter, Adrian; Liedl, Klaus R; Vangone, Anna

CD3

发表日期：2026

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Balancing the extremes for antibody developability: hydrophobic and electrostatic germline framework signatures for CDR-loop compensation

平衡抗体开发中的极端因素：用于补偿 CDR 环的疏水性和静电种系框架特征

期刊:MAbs

影响因子:7.3

doi:10.1080/19420862.2026.2627669

Spanke, Vera A; Egger-Hoerschinger, Valentin J; Seidler, Clarissa A; Kroell, Katharina B; Wieser, Vincent; Imhof-Jung, Sabine; Weiche, Benjamin; Bujotzek, Alexander; Georges, Guy; Liedl, Klaus R

发表日期：2026

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Data-driven analyses of human antibody variable domain germlines: pairings, sequences and structural features

基于数据的人类抗体可变区种系分析：配对、序列和结构特征

期刊:MAbs

影响因子:7.3

doi:10.1080/19420862.2025.2507950

Seidler, Clarissa A; Spanke, Vera A; Gamper, Jakob; Bujotzek, Alexander; Georges, Guy; Liedl, Klaus R

发表日期：2025

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Micellar Solvent Accessibility of Esterified Polyoxyethylene Chains as Crucial Element of Polysorbate Oxidation: A Density Functional Theory, Molecular Dynamics Simulation and Liquid Chromatography/Mass Spectrometry Investigation

酯化聚氧乙烯链的胶束溶剂可及性是聚山梨醇酯氧化的关键因素：密度泛函理论、分子动力学模拟和液相色谱/质谱研究

期刊:Molecular Pharmaceutics

影响因子:4.5

doi:10.1021/acs.molpharmaceut.4c01015

Weber, Johanna; Pedri, Leonardo; Peters, Luis P; Quoika, Patrick K; Dinu, Dennis F; Liedl, Klaus R; Tautermann, Christofer S; Diederichs, Tim; Garidel, Patrick

发表日期：2025

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Encasing the paramagnetic copper(II)-ion by the ring-contracted corrin ligand of vitamin B(12)

用维生素 B(12) 的环收缩咕啉配体包裹顺磁性铜(II)离子

期刊:Chemical Communications

影响因子:4.2

doi:10.1039/d5cc02129d

Kieninger, Christoph; Wurst, Klaus; Leitner, Daniel; Peters, Luis P; Dinu, Dennis F; Wiedemair, Markus; Zaretzke, Marc-Kevin; Bröring, Martin; Hohloch, Stephan; Liedl, Klaus R; Kräutler, Bernhard

发表日期：2025

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Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses

托特罗定是一种新型候选药物，可通过代谢挥发物评估CYP3A4活性，从而预测药物反应。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-86450-9

Stock, Valentina; Hofer, Rebecca; Lochmann, Franziska; Spanke, Vera; Liedl, Klaus R; Troppmair, Jakob; Langer, Thierry; Gstach, Hubert; Dank, Christian; Mayhew, Chris A; Kammerer, Sarah; Ruzsanyi, Veronika

Towards the Use of Metabolic Volatiles in Breath for Determining Drug Response: Gstachamine as an Unlabeled Substrate to Measure CYP3A4 Activity

利用呼气代谢挥发物测定药物反应：以谷氨酰胺作为未标记底物测定CYP3A4活性

期刊:ChemMedChem

影响因子:3.4

doi:10.1002/cmdc.202500492

Stock, Valentina; Hofer, Rebecca; Liedl, Klaus R; Troppmair, Jakob; Langer, Thierry; Gstach, Hubert; Dank, Christian; Kammerer, Sarah; Ruzsanyi, Veronika

From closed to open: three dynamic states of membrane-bound cytochrome P450 3A4

从关闭到开放：膜结合细胞色素P450 3A4的三种动态状态

期刊:Journal of Computer-Aided Molecular Design

影响因子:3.1

doi:10.1007/s10822-025-00589-1

Spanke, Vera A; Egger-Hoerschinger, Valentin J; Ruzsanyi, Veronika; Liedl, Klaus R

细胞生物学

发表日期：2025

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Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation

电压传感器门控电荷相互作用以双峰方式调节钙通道激活的电压依赖性和动力学。

期刊:Journal of General Physiology

影响因子:2.9

doi:10.1085/jgp.202513769

Heiss, Martin C; Fernández-Quintero, Monica L; Campiglio, Marta; El Ghaleb, Yousra; Pelizzari, Simone; Loeffler, Johannes R; Liedl, Klaus R; Tuluc, Petronel; Flucher, Bernhard E

发表日期：2025

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Functional characterization of a novel de novo CACNA1C pathogenic variant in a patient with neurodevelopmental disorder

对一名患有神经发育障碍的患者中新发现的 CACNA1C 致病变异进行功能表征

期刊:Molecular Brain

影响因子:2.9

doi:10.1186/s13041-025-01195-w

Stringer, Robin N; Tang, Xuechen; Jurkovicova-Tarabova, Bohumila; Murphy, Mary; Liedl, Klaus R; Weiss, Norbert

Engineering of acidic pH-responsive anti-CD3 binding antibodies

酸性pH响应型抗CD3结合抗体的工程改造

Balancing the extremes for antibody developability: hydrophobic and electrostatic germline framework signatures for CDR-loop compensation

平衡抗体开发中的极端因素：用于补偿 CDR 环的疏水性和静电种系框架特征

Data-driven analyses of human antibody variable domain germlines: pairings, sequences and structural features

基于数据的人类抗体可变区种系分析：配对、序列和结构特征

Micellar Solvent Accessibility of Esterified Polyoxyethylene Chains as Crucial Element of Polysorbate Oxidation: A Density Functional Theory, Molecular Dynamics Simulation and Liquid Chromatography/Mass Spectrometry Investigation

酯化聚氧乙烯链的胶束溶剂可及性是聚山梨醇酯氧化的关键因素：密度泛函理论、分子动力学模拟和液相色谱/质谱研究

Encasing the paramagnetic copper(II)-ion by the ring-contracted corrin ligand of vitamin B(12)

用维生素 B(12) 的环收缩咕啉配体包裹顺磁性铜(II)离子

Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses

托特罗定是一种新型候选药物，可通过代谢挥发物评估CYP3A4活性，从而预测药物反应。

Towards the Use of Metabolic Volatiles in Breath for Determining Drug Response: Gstachamine as an Unlabeled Substrate to Measure CYP3A4 Activity

利用呼气代谢挥发物测定药物反应：以谷氨酰胺作为未标记底物测定CYP3A4活性

From closed to open: three dynamic states of membrane-bound cytochrome P450 3A4

从关闭到开放：膜结合细胞色素P450 3A4的三种动态状态

Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation

电压传感器门控电荷相互作用以双峰方式调节钙通道激活的电压依赖性和动力学。

Functional characterization of a novel de novo CACNA1C pathogenic variant in a patient with neurodevelopmental disorder

对一名患有神经发育障碍的患者中新发现的 CACNA1C 致病变异进行功能表征