日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine

用AS03佐剂COVID-19疫苗免疫猕猴后,产生了针对沙贝病毒的广谱中和抗体

Feng, Yupeng; Yuan, Meng; Powers, John M; Hu, Mengyun; Munt, Jennifer E; Arunachalam, Prabhu S; Leist, Sarah R; Bellusci, Lorenza; Kim, JungHyun; Sprouse, Kaitlin R; Adams, Lily E; Sundaramurthy, Sumana; Zhu, Xueyong; Shirreff, Lisa M; Mallory, Michael L; Scobey, Trevor D; Moreno, Alberto; O'Hagan, Derek T; Kleanthous, Harry; Villinger, Francois J; Veesler, David; King, Neil P; Suthar, Mehul S; Khurana, Surender; Baric, Ralph S; Wilson, Ian A; Pulendran, Bali

Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques

GBP510/AS03疫苗对恒河猴SARS-CoV-2 delta攻击的免疫原性和保护效力

Jacob-Dolan, Catherine; Yu, Jingyou; McMahan, Katherine; Giffin, Victoria; Chandrashekar, Abishek; Martinot, Amanda J; Anioke, Tochi; Powers, Olivia C; Hall, Kevin; Hope, David; Miller, Jessica; Hachmann, Nichole P; Chung, Benjamin; Gardner, Sarah; Sellers, Daniel; Barrett, Julia; Lewis, Mark G; Andersen, Hanne; Kleanthous, Harry; Seo, Ki-Woen; Lee, Su Jeen; Park, Yong Wook; Kim, Hun; Barouch, Dan H

Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD)

铝盐、CpG 和乳剂佐剂对展示 SARS-CoV-2 受体结合域 (RBD) 的病毒样颗粒的稳定性和免疫原性的影响

Kumru, Ozan S; Bajoria, Sakshi; Kaur, Kawaljit; Hickey, John M; Van Slyke, Greta; Doering, Jennifer; Berman, Katherine; Richardson, Charles; Lien, Hans; Kleanthous, Harry; Mantis, Nicholas J; Joshi, Sangeeta B; Volkin, David B

Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants.

对刺突蛋白 RBD 中隐蔽表位进行分子工程改造,可提高其生产性能和对 SARS-CoV-2 变种的中和广度

Rodriguez-Aponte Sergio A, Dalvie Neil C, Wong Ting Y, Johnston Ryan S, Naranjo Christopher A, Bajoria Sakshi, Kumru Ozan S, Kaur Kawaljit, Russ Brynnan P, Lee Katherine S, Cyphert Holly A, Barbier Mariette, Rao Harish D, Rajurkar Meghraj P, Lothe Rakesh R, Shaligram Umesh S, Batwal Saurabh, Chandrasekaran Rahul, Nagar Gaurav, Kleanthous Harry, Biswas Sumi, Bevere Justin R, Joshi Sangeeta B, Volkin David B, Damron F Heath, Love J Christopher

Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018(TM) Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen

含氢氧化铝和CpG 1018(TM)佐剂的纳米明矾制剂:对重组SARS-CoV-2 RBD抗原稳定性和免疫原性的影响

Bajoria, Sakshi; Kumru, Ozan S; Doering, Jennifer; Berman, Katherine; Slyke, Greta Van; Prigodich, Anneka; Rodriguez-Aponte, Sergio A; Kleanthous, Harry; Love, J Christopher; Mantis, Nicholas J; Joshi, Sangeeta B; Volkin, David B

Effect of adjuvanting RBD-dimer-based subunit COVID-19 vaccines with Sepivac SWE™

Sepivac SWE™佐剂对基于RBD二聚体的亚单位COVID-19疫苗的影响

Xu, Senyu; Duan, Huixin; An, Yaling; Jin, Xiyue; Duan, Minrun; Dubois, Patrice M; Huang, Yan; Xu, Kun; Du, Heng; Kleanthous, Harry; Dai, Lianpan; Gao, George F

Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2

用AS03佐剂单价亚单位疫苗免疫猕猴后,产生了效力极强的泛沙贝病毒中和抗体,该疫苗可对抗SARS-CoV-2病毒。

Feng, Yupeng; Yuan, Meng; Powers, John M; Hu, Mengyun; Munt, Jennifer E; Arunachalam, Prabhu S; Leist, Sarah R; Bellusci, Lorenza; Adams, Lily E; Sundaramurthy, Sumana; Shirreff, Lisa M; Mallory, Michael L; Scooby, Trevor D; Moreno, Alberto; O'Hagan, Derek T; Kleanthous, Harry; Villinger, Francois J; Veesler, David; King, Neil P; Suthar, Mehul S; Khurana, Surender; Baric, Ralph S; Wilson, Ian A; Pulendran, Bali

Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B

针对识别艰难梭菌毒素B糖基转移酶结构域非重叠表位的单克隆抗体,我们获得了新的结构见解

Liu, Jinyu; Kothe, Michael; Zhang, Jianxin; Oloo, Eliud; Stegalkina, Svetlana; Mundle, Sophia T; Li, Lu; Zhang, Jinrong; Cole, Leah E; Barone, Lucianna; Biemann, Hans-Peter; Kleanthous, Harry; Anosova, Natalie G; Anderson, Stephen F

Scientific rationale for developing potent RBD-based vaccines targeting COVID-19

开发针对新冠病毒的高效RBD疫苗的科学依据

Kleanthous, Harry; Silverman, Judith Maxwell; Makar, Karen W; Yoon, In-Kyu; Jackson, Nicholas; Vaughn, David W

Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates

在非人灵长类动物中,使用佐剂诱导亚单位SARS-CoV-2纳米颗粒疫苗产生保护性免疫

S Arunachalam, Prabhu; Walls, Alexandra C; Golden, Nadia; Atyeo, Caroline; Fischinger, Stephanie; Li, Chunfeng; Aye, Pyone; Navarro, Mary Jane; Lai, Lilin; Edara, Venkata Viswanadh; Roltgen, Katharina; Rogers, Kenneth; Shirreff, Lisa; Ferrell, Douglas E; Wrenn, Samuel; Pettie, Deleah; Kraft, John C; Miranda, Marcos C; Kepl, Elizabeth; Sydeman, Claire; Brunette, Natalie; Murphy, Michael; Fiala, Brooke; Carter, Lauren; White, Alexander G; Trisal, Meera; Hsieh, Ching-Lin; Russell-Lodrigue, Kasi; Monjure, Christopher; Dufour, Jason; Doyle-Meyer, Lara; Bohm, Rudolph B; Maness, Nicholas J; Roy, Chad; Plante, Jessica A; Plante, Kenneth S; Zhu, Alex; Gorman, Matthew J; Shin, Sally; Shen, Xiaoying; Fontenot, Jane; Gupta, Shakti; O Hagan, Derek T; Most, Robbert Van Der; Rappuoli, Rino; Coffman, Robert L; Novack, David; McLellan, Jason S; Subramaniam, Shankar; Montefiori, David; Boyd, Scott D; Flynn, JoAnne L; Alter, Galit; Villinger, Francois; Kleanthous, Harry; Rappaport, Jay; Suthar, Mehul; King, Neil P; Veesler, David; Pulendran, Bali