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Inhibition of adenylyl cyclase 1 (AC1) and exchange protein directly activated by cAMP (EPAC) restores ATP-sensitive potassium (K(ATP)) channel activity after chronic opioid exposure.

抑制腺苷酸环化酶 1 (AC1) 和 cAMP 直接激活的交换蛋白 (EPAC) 可恢复慢性阿片类药物暴露后 ATP 敏感钾 (K(ATP)) 通道的活性

doi:10.1101/2025.02.03.636278

Klein Amanda H, Alam Sabbir, Johnson Kayla, Kriner Christian, Beck Brie, Nelson Bethany, Hill Cassidy, Meyer Belle, Mellang Jonas, Watts Val J

Loss of ATP-Sensitive Potassium Channel Expression and Function in the Nervous System Decreases Opioid Sensitivity in a High-Fat Diet-Fed Mouse Model of Diet-Induced Obesity.

神经系统中 ATP 敏感钾通道表达和功能的丧失降低了高脂饮食诱导肥胖小鼠模型的阿片类药物敏感性

期刊:Diabetes

影响因子:7.5

doi:10.2337/db23-1030

Fisher Cole, Johnson Kayla, Moore Madelyn, Sadrati Amir, Janecek Jody L, Graham Melanie L, Klein Amanda H

Chemogenic Subqualities of Mouthfeel

化学因素对口感的影响

期刊:Chemical Senses

影响因子:1.9

doi:10.1093/chemse/bjz016

Simons, Christopher T; Klein, Amanda H; Carstens, Earl

发表日期：2019

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The orotrigeminal system

口三叉神经系统

期刊:Handbook of Clinical Neurology

影响因子:

doi:10.1016/B978-0-444-63855-7.00013-7

Klein, Amanda H

发表日期：2019

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Overexpression of µ-Opioid Receptors in Peripheral Afferents, but Not in Combination with Enkephalin, Decreases Neuropathic Pain Behavior and Enhances Opioid Analgesia in Mouse

外周传入神经中μ-阿片受体的过表达（而非与脑啡肽联合表达）可降低小鼠的神经性疼痛行为并增强阿片类镇痛作用。

期刊:Anesthesiology

影响因子:9.1

doi:10.1097/ALN.0000000000002063

Klein, Amanda H; Mohammad, Husam K; Ali, Rabiah; Peper, Brad; Wilson, Steven P; Raja, Srinivasa N; Ringkamp, Matthias; Sweitzer, Sarah

Sodium Channel Na(v)1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves

钠通道Na(v)1.8是远端皮肤神经体感C纤维中TTX耐受性轴突动作电位传导的基础

期刊:Journal of Neuroscience

影响因子:4

doi:10.1523/JNEUROSCI.3799-16.2017

Klein, Amanda H; Vyshnevska, Alina; Hartke, Timothy V; De Col, Roberto; Mankowski, Joseph L; Turnquist, Brian; Bosmans, Frank; Reeh, Peter W; Schmelz, Martin; Carr, Richard W; Ringkamp, Matthias

发表日期：2017

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Three functionally distinct classes of C-fibre nociceptors in primates

灵长类动物中三种功能不同的C纤维伤害感受器

期刊:Nature Communications

影响因子:15.7

doi:10.1038/ncomms5122

Wooten, Matthew; Weng, Hao-Jui; Hartke, Timothy V; Borzan, Jasenka; Klein, Amanda H; Turnquist, Brian; Dong, Xinzhong; Meyer, Richard A; Ringkamp, Matthias

发表日期：2014

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The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat

局部应用丙泊酚对大鼠脊髓背角神经元的镇痛和抗痛觉过敏作用

期刊:Anesthesia and Analgesia

影响因子:3.8

doi:10.1213/ANE.0b013e31827f560d

Takechi, Kenichi; Carstens, Mirela Iodi; Klein, Amanda H; Carstens, E

A tingling sanshool derivative excites primary sensory neurons and elicits nocifensive behavior in rats

具有刺痛感的山椒衍生物能兴奋大鼠的初级感觉神经元，并引发伤害性防御行为。

期刊:Journal of Neurophysiology

影响因子:2.1

doi:10.1152/jn.00922.2010

Klein, Amanda H; Sawyer, Carolyn M; Zanotto, Karen L; Ivanov, Margaret A; Cheung, Susan; Carstens, Mirela Iodi; Furrer, Stephan; Simons, Christopher T; Slack, Jay P; Carstens, E

Pharmacologically enabling the degradation of Na V 1.8 channels to reduce neuropathic pain

通过药物手段促进Na<sub>v</sub>1.8通道的降解，从而减轻神经性疼痛

Inhibition of adenylyl cyclase 1 (AC1) and exchange protein directly activated by cAMP (EPAC) restores ATP-sensitive potassium (K(ATP)) channel activity after chronic opioid exposure.

抑制腺苷酸环化酶 1 (AC1) 和 cAMP 直接激活的交换蛋白 (EPAC) 可恢复慢性阿片类药物暴露后 ATP 敏感钾 (K(ATP)) 通道的活性

Loss of ATP-Sensitive Potassium Channel Expression and Function in the Nervous System Decreases Opioid Sensitivity in a High-Fat Diet-Fed Mouse Model of Diet-Induced Obesity.

神经系统中 ATP 敏感钾通道表达和功能的丧失降低了高脂饮食诱导肥胖小鼠模型的阿片类药物敏感性

Chemogenic Subqualities of Mouthfeel

化学因素对口感的影响

The orotrigeminal system

口三叉神经系统

Overexpression of µ-Opioid Receptors in Peripheral Afferents, but Not in Combination with Enkephalin, Decreases Neuropathic Pain Behavior and Enhances Opioid Analgesia in Mouse

外周传入神经中μ-阿片受体的过表达（而非与脑啡肽联合表达）可降低小鼠的神经性疼痛行为并增强阿片类镇痛作用。

Sodium Channel Na(v)1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves

钠通道Na(v)1.8是远端皮肤神经体感C纤维中TTX耐受性轴突动作电位传导的基础

Three functionally distinct classes of C-fibre nociceptors in primates

灵长类动物中三种功能不同的C纤维伤害感受器

The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat

局部应用丙泊酚对大鼠脊髓背角神经元的镇痛和抗痛觉过敏作用

A tingling sanshool derivative excites primary sensory neurons and elicits nocifensive behavior in rats

具有刺痛感的山椒衍生物能兴奋大鼠的初级感觉神经元，并引发伤害性防御行为。