日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders

遗传相关性分析发现,TMEM106B、ACE 和 ERC2 是阿尔茨海默病和原发性精神疾病共有的基因位点。

Kumar, Ajneesh; Ray, Nicholas R; Kurup, Jiji T; Rosario, Pamela Del; Manoochehri, Masood; Stein, Colin; De Vito, Alyssa N; Cholerton, Brenna; Sweet, Robert A; de Jager, Phil L; Klein, Hans-Ulrich; Cuccaro, Michael L; Beecham, Gary W; Huey, Edward D; Reitz, Christiane

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer's Disease

利用脂质性状进行局部遗传协方差分析,发现了早发性阿尔茨海默病的新基因位点

Ray, Nicholas R; Bradley, Joseph; Yilmaz, Elanur; Kizil, Caghan; Kurup, Jiji T; Martin, Eden R; Klein, Hans-Ulrich; Kunkle, Brian W; Bennett, David A; De Jager, Philip L; Beecham, Gary W; Cruchaga, Carlos; Reitz, Christiane

PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer's Disease

PLXNB1和其他信号通路驱动星形胶质细胞病理状态,从而导致阿尔茨海默病患者的认知能力下降。

Comandante-Lou, Natacha; Lama, Tsering; Chen, Kevin; Zhang, Jinglong; Hu, Bin; Liu, Shuhui; Heuer, Sarah; Brennand, Kristen J; Schneider, Julie; Barnes, Lisa; Zhang, Bin; Wang, Minghui; Zou, Hongyan; Friedel, Roland H; Ma, Yiyi; Young-Pearse, Tracy; Li, Aiqun; Fujita, Masashi; Bennett, David; Zhang, Ya; Menon, Vilas; Klein, Hans-Ulrich; Taga, Mariko; De Jager, Philip L

A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature.

基于因子分析的人类小胶质细胞个体研究揭示了阿尔茨海默病相关转录特征的调节因子

Marshe Victoria S, Tuddenham John F, Chen Kevin, Chiu Rebecca, Haage Verena C, Ma Yiyi, Lee Annie J, Shneider Neil A, Agin-Liebes Julian P, Alcalay Roy N, Teich Andrew F, Canoll Peter, Riley Claire S, Keene Dirk, Schneider Julie A, Bennett David A, Menon Vilas, Taga Mariko, Klein Hans-Ulrich, Olah Marta, Fujita Masashi, Zhang Ya, Sims Peter A, De Jager Philip L

Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain.

阿尔茨海默病脑中基因变异的细胞亚型特异性效应

Fujita Masashi, Gao Zongmei, Zeng Lu, McCabe Cristin, White Charles C, Ng Bernard, Green Gilad Sahar, Rozenblatt-Rosen Orit, Phillips Devan, Amir-Zilberstein Liat, Lee Hyo, Pearse Richard V 2nd, Khan Atlas, Vardarajan Badri N, Kiryluk Krzysztof, Ye Chun Jimmie, Klein Hans-Ulrich, Wang Gao, Regev Aviv, Habib Naomi, Schneider Julie A, Wang Yanling, Young-Pearse Tracy, Mostafavi Sara, Bennett David A, Menon Vilas, De Jager Philip L

Psychosocial experiences are associated with human brain mitochondrial biology.

社会心理经历与人类大脑线粒体生物学有关

Trumpff Caroline, Monzel Anna S, Sandi Carmen, Menon Vilas, Klein Hans-Ulrich, Fujita Masashi, Lee Annie, Petyuk Vladislav A, Hurst Cheyenne, Duong Duc M, Seyfried Nicholas T, Wingo Aliza P, Wingo Thomas S, Wang Yanling, Thambisetty Madhav, Ferrucci Luigi, Bennett David A, De Jager Philip L, Picard Martin

A Single-Nucleus Transcriptome-Wide Association Study Implicates Novel Genes in Depression Pathogenesis

一项单核转录组关联研究揭示了与抑郁症发病机制相关的新基因

Zeng, Lu; Fujita, Masashi; Gao, Zongmei; White, Charles C; Green, Gilad S; Habib, Naomi; Menon, Vilas; Bennett, David A; Boyle, Patricia; Klein, Hans-Ulrich; De Jager, Philip L

Proteome-wide Analyses Identified Cortical Proteins Associated With Resilience for Varied Cognitive Abilities

全蛋白质组分析鉴定出与不同认知能力韧性相关的皮质蛋白

Zammit, Andrea R; Klein, Hans-Ulrich; Yu, Lei; Levey, Allan I; Seyfried, Nicholas T; Wingo, Aliza P; Wingo, Thomas S; Schneider, Julie A; Bennett, David A; Buchman, Aron S

Glycoproteome-Wide Discovery of Cortical Glycoproteins That May Provide Cognitive Resilience in Older Adults

糖蛋白组学研究发现皮质糖蛋白可能为老年人提供认知韧性

Buchman, Aron S; Yu, Lei; Klein, Hans-Ulrich; Zammit, Andrea R; Oveisgharan, Shahram; Nag, Sukriti; Tickotsky, Nili; Levy, Hila; Seyfried, Nicholas; Morgenstern, David; Levin, Yishai; Schnaider Beeri, Michal; Bennett, David A

Genetic insights into the association between inflammatory bowel disease and Alzheimer's disease

炎症性肠病与阿尔茨海默病之间关联的遗传学见解

Zeng, Lu; White, Charles C; Bennett, David A; Klein, Hans-Ulrich; De Jager, Philip L