日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Remotely acting SMCHD1 gene regulatory elements: in silico prediction and identification of potential regulatory variants in patients with FSHD

远程调控SMCHD1基因的调控元件:计算机模拟预测和鉴定FSHD患者中潜在的调控变异

Mayes, Mary B; Morgan, Taniesha; Winston, Jincy; Buxton, Daniel S; Kamat, Mihir Anant; Smith, Debbie; Williams, Maggie; Martin, Rebecca L; Kleinjan, Dirk A; Cooper, David N; Upadhyaya, Meena; Chuzhanova, Nadia

Identification of novel craniofacial regulatory domains located far upstream of SOX9 and disrupted in Pierre Robin sequence

鉴定出位于 SOX9 上游远端且在 Pierre Robin 序列中被破坏的新型颅面调控结构域

Gordon, Christopher T; Attanasio, Catia; Bhatia, Shipra; Benko, Sabina; Ansari, Morad; Tan, Tiong Y; Munnich, Arnold; Pennacchio, Len A; Abadie, Véronique; Temple, I Karen; Goldenberg, Alice; van Heyningen, Veronica; Amiel, Jeanne; FitzPatrick, David; Kleinjan, Dirk A; Visel, Axel; Lyonnet, Stanislas

Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver

对1型糖尿病成年小鼠和老年血糖正常小鼠肝脏进行基因组分析

Ghiraldini, Flávia G; Silveira, André B; Kleinjan, Dirk A; Gilbert, Nick; Mello, Maria Luiza S

Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences

对象鲨Pax6基因座的测序揭示了脊椎动物基因组中存在一个Pax6基因家族,该家族是由远古时期的基因复制和分化形成的。

Ravi, Vydianathan; Bhatia, Shipra; Gautier, Philippe; Loosli, Felix; Tay, Boon-Hui; Tay, Alice; Murdoch, Emma; Coutinho, Pedro; van Heyningen, Veronica; Brenner, Sydney; Venkatesh, Byrappa; Kleinjan, Dirk A

The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreas

发育调控因子Pax6对于维持成年小鼠胰腺中胰岛细胞的功能至关重要。

Hart, Alan W; Mella, Sebastien; Mendrychowski, Jacek; van Heyningen, Veronica; Kleinjan, Dirk A

DNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region.

DNaseI 超敏感性和超保守性揭示了复杂的 Pax6 顺式调控区域中新的、相互依赖的长程增强子

McBride David J, Buckle Adam, van Heyningen Veronica, Kleinjan Dirk A

Effects of elevated Pax6 expression and genetic background on mouse eye development.

Pax6 表达升高和遗传背景对小鼠眼部发育的影响

Chanas Simon A, Collinson J Martin, Ramaesh Thaya, Dorà Natalie, Kleinjan Dirk A, Hill Robert E, West John D

Mosaic analysis of stem cell function and wound healing in the mouse corneal epithelium

小鼠角膜上皮干细胞功能和伤口愈合的嵌合体分析

Mort, Richard L; Ramaesh, Thaya; Kleinjan, Dirk A; Morley, Steven D; West, John D

Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence.

斑马鱼 pax6 基因重复通过顺式调控分歧发生亚功能化

Kleinjan Dirk A, Bancewicz Ruth M, Gautier Philippe, Dahm Ralf, Schonthaler Helia B, Damante Giuseppe, Seawright Anne, Hever Ann M, Yeyati Patricia L, van Heyningen Veronica, Coutinho Pedro

Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse

利用新型转基因报告小鼠证实了Pax6调控元件在人类和小鼠中的功能保守性

Tyas, David A; Simpson, T Ian; Carr, Catherine B; Kleinjan, Dirk A; van Heyningen, Veronica; Mason, John O; Price, David J