日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EZ-DMS - A Simple and Accessible Protocol and Software Package for Deep Mutational Scanning of Virus Proteins

EZ-DMS——一种用于病毒蛋白深度突变扫描的简单易用的协议和软件包

Gillman, Aaron N; Broghammer, Madeline M; McCarthy-Potter, Samuel A; Vujjini, Rohith Rao; Birler, Cassian M; Kleinpeter, Alexander B; Haim, Hillel

Structural basis for HIV-1 capsid adaption to a deficiency in IP6 packaging.

HIV-1 衣壳适应 IP6 包装缺陷的结构基础

Zhu Yanan, Kleinpeter Alex B, Rey Juan S, Shen Juan, Shen Yao, Xu Jialu, Hardenbrook Nathan, Chen Long, Lucic Anka, Perilla Juan R, Freed Eric O, Zhang Peijun

Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir.

M66I衣壳变体对lenacapavir产生耐药性的结构和机制基础

Briganti Lorenzo, Annamalai Arun S, Bester Stephanie M, Wei Guochao, Andino-Moncada Jonathan R, Singh Satya P, Kleinpeter Alex B, Tripathi Meghna, Nguyen Binh, Radhakrishnan Rajalingam, Singh Parmit K, Greenwood Juliet, Schope Lauren I, Haney Reed, Huang Szu-Wei, Freed Eric O, Engelman Alan N, Francis Ashwanth C, Kvaratskhelia Mamuka

Structural basis for HIV-1 capsid adaption to rescue IP6-packaging deficiency

HIV-1衣壳适应性修复IP6包装缺陷的结构基础

Zhu, Yanan; Kleinpeter, Alex B; Rey, Juan S; Shen, Juan; Shen, Yao; Xu, Jialu; Hardenbrook, Nathan; Chen, Long; Lucic, Anka; Perilla, Juan R; Freed, Eric O; Zhang, Peijun

The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid.

HIV-1 衣壳蛋白的中心孔促进病毒衣壳的持续稳定性

Kleinpeter Alex B, Mallery Donna L, Albecka Anna, Burdick Ryan C, Renner Nadine, Klarhof J Ole, Vamos Boglarka, Pathak Vinay K, James Leo C, Freed Eric O

HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly

HIV-1 通过第二位点突变来适应失去的 IP6 协调,从而恢复锥形衣壳的组装

Alex Kleinpeter #, Donna L Mallery #, Nadine Renner #, Anna Albecka, J Ole Klarhof, Eric O Freed, Leo C James

TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody, favors tumor regression via profound immune remodeling of the tumor microenvironment

TG6050是一种溶瘤痘苗病毒,编码白细胞介素-12和抗CTLA-4抗体,它通过对肿瘤微环境进行深刻的免疫重塑来促进肿瘤消退。

Azar, Fadi; Deforges, Jules; Demeusoit, Christelle; Kleinpeter, Patricia; Remy, Christelle; Silvestre, Nathalie; Foloppe, Johann; Fend, Laetitia; Spring-Giusti, Clémentine; Quéméneur, Eric; Marchand, Jean-Baptiste

Mediation of antitumor activity by AZD4820 oncolytic vaccinia virus encoding IL-12

编码 IL-12 的 AZD4820 溶瘤痘苗病毒介导抗肿瘤活性

Cheyne Kurokawa, Sonia Agrawal, Abhisek Mitra, Elena Galvani, Shannon Burke, Ankita Varshine, Raymond Rothstein, Kevin Schifferli, Noel R Monks, Johann Foloppe, Nathalie Silvestre, Eric Quemeneur, Christelle Demeusoit, Patricia Kleinpeter, Puja Sapra, Carl Barrett, Scott A Hammond, Elizabeth J Kelly

Structural basis of HIV-1 maturation inhibitor binding and activity

HIV-1成熟抑制剂结合和活性的结构基础

Sarkar, Sucharita; Zadrozny, Kaneil K; Zadorozhnyi, Roman; Russell, Ryan W; Quinn, Caitlin M; Kleinpeter, Alex; Ablan, Sherimay; Meshkin, Hamed; Perilla, Juan R; Freed, Eric O; Ganser-Pornillos, Barbie K; Pornillos, Owen; Gronenborn, Angela M; Polenova, Tatyana

HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly

HIV-1 依赖其未成熟的晶格来招募 IP6 进行成熟的衣壳组装

Nadine Renner #, Alex Kleinpeter #, Donna L Mallery #, Anna Albecka, K M Rifat Faysal, Till Böcking, Adolfo Saiardi, Eric O Freed, Leo C James