日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural modification of oxazolidinone antibiotics alters nascent peptide stalling preference and peptide trajectory through the ribosome.

恶唑烷酮类抗生素的结构修饰会改变新生肽的停滞偏好和肽在核糖体中的运动轨迹。

Kleinman Jordan I, Raskar Tushar, Klepacki Dorota, Szal Teresa, Vázquez-Laslop Nora, Mankin Alexander S, Fraser James S, Fujimori Danica Galonić

A Natural Depsipeptide Antibiotic that Targets the E site of the Bacterial Ribosome.

一种靶向细菌核糖体E位点的天然去肽类抗生素。

Wright Gerard, Kaur Manpreet, Travin Dmitrii, Berger Max, Jangra Manoj, Morici Martino, Safdari Haaris Ahsan, Klepacki Dorota, Wang Wenliang, Cook Michael, Chou Sommer, Guitor Allison, Koteva Kalinka, Xu Min, Ejim Linda, Macneil Lesley, Vázquez-Laslop Nora, Mankin Alexander, Wilson Daniel

Saskemycin, a potent and selective antimycobacterial agent targeting a unique site on the ribosome.

Saskemycin 是一种强效且选择性的抗分枝杆菌药物,靶向核糖体上的独特位点。

Wright Gerard, Cook Michael, Xu Min, Morici Martino, Travin Dmitrii, Wang Wenliang, Klepacki Dorota, Chhabra Nandini, Rao Vishwas, Sahile Henok, Hackenberger Dirk, Safdari Haaris, Berger Max, Corazza Martina, Bond Austin, Guitor Allison, Tertigas Dominique, Wang Lijun, Schaenzer Adam, Ejim Linda, Yarlagadda Venkateswarlu, Gomez James, Surette Michael, Av-Gay Yossef, Dhar Neeraj, Hung Deborah, Vázquez-Laslop Nora, Mankin Alexander, Wilson Daniel

Sequence-specific trapping of EF-Tu/glycyl-tRNA complex on the ribosome by bottromycin.

博特霉素对核糖体上 EF-Tu/甘氨酰-tRNA 复合物的序列特异性捕获

Travin Dmitrii Y, Basu Ritwika S, Paranjpe Madhura N, Klepacki Dorota, Zhurakovskaya Anna I, Vázquez-Laslop Nora, Mankin Alexander S, Polikanov Yury S, Gagnon Matthieu G

Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms

大环内酯类抗生素靶向细菌核糖体和DNA促旋酶,能够逃避细菌的耐药机制。

Aleksandrova, Elena V; Ma, Cong-Xuan; Klepacki, Dorota; Alizadeh, Faezeh; Vázquez-Laslop, Nora; Liang, Jian-Hua; Polikanov, Yury S; Mankin, Alexander S

Inhibition of translation termination by the antimicrobial peptide Drosocin

抗菌肽Drosocin对翻译终止的抑制作用

Mangano, Kyle; Klepacki, Dorota; Ohanmu, Irueosa; Baliga, Chetana; Huang, Weiping; Brakel, Alexandra; Krizsan, Andor; Polikanov, Yury S; Hoffmann, Ralf; Vázquez-Laslop, Nora; Mankin, Alexander S

A method for tritiation of iboxamycin permits measurement of its ribosomal binding

一种用于氚标记异博沙霉素的方法可以测量其核糖体结合能力。

Wu, Kelvin J Y; Klepacki, Dorota; Mankin, Alexander S; Myers, Andrew G

Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics

恶唑烷酮类抗生素对翻译的上下文特异性抑制的结构基础

Tsai, Kaitlyn; Stojković, Vanja; Lee, D John; Young, Iris D; Szal, Teresa; Klepacki, Dorota; Vázquez-Laslop, Nora; Mankin, Alexander S; Fraser, James S; Fujimori, Danica Galonić

Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol

经典肽基转移酶抑制剂氯霉素的上下文特异性作用的结构基础

Syroegin, Egor A; Flemmich, Laurin; Klepacki, Dorota; Vazquez-Laslop, Nora; Micura, Ronald; Polikanov, Yury S

The context of the ribosome binding site in mRNAs defines specificity of action of kasugamycin, an inhibitor of translation initiation

mRNA中核糖体结合位点的上下文决定了卡那霉素(一种翻译起始抑制剂)的作用特异性。

Zhang, Yan; Aleksashin, Nikolay A; Klepacki, Dorota; Anderson, Caleb; Vázquez-Laslop, Nora; Gross, Carol A; Mankin, Alexander S