日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.

深度 CRISPR 诱变表征了 TP53 突变的功能多样性

Funk Julianne S, Klimovich Maria, Drangenstein Daniel, Pielhoop Ole, Hunold Pascal, Borowek Anna, Noeparast Maxim, Pavlakis Evangelos, Neumann Michelle, Balourdas Dimitrios-Ilias, Kochhan Katharina, Merle Nastasja, Bullwinkel Imke, Wanzel Michael, Elmshäuser Sabrina, Teply-Szymanski Julia, Nist Andrea, Procida Tara, Bartkuhn Marek, Humpert Katharina, Mernberger Marco, Savai Rajkumar, Soussi Thierry, Joerger Andreas C, Stiewe Thorsten

Loss of p53 function at late stages of tumorigenesis confers ARF-dependent vulnerability to p53 reactivation therapy

肿瘤发生后期p53功能的丧失赋予了肿瘤细胞ARF依赖性的对p53再激活疗法的易感性。

Klimovich, Boris; Mutlu, Samet; Schneikert, Jean; Elmshäuser, Sabrina; Klimovich, Maria; Nist, Andrea; Mernberger, Marco; Timofeev, Oleg; Stiewe, Thorsten