文献库，生知库 | 链接生命科学的每一步

日期影响因子

Informed mutation of western equine encephalitis virus to heparan sulfate binding: Implications for rational design of alphavirus live attenuated vaccines

西部马脑炎病毒与硫酸乙酰肝素结合的知情突变：对合理设计甲病毒减毒活疫苗的启示

期刊:PLoS Pathogens

影响因子:4.9

doi:10.1371/journal.ppat.1013941

Lukash, Tetyana; Poudyal, Shishir; Gilliland, Theron C Jr; Klose, Thomas; Sun, Chengqun; Vasilatos, Shauna N; Farren, Jessica L; Lam, Long Kwan Metthew; Kuhn, Richard J; Klimstra, William B

发表日期：2026

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A single dose of purified human antibody from transchromosomic bovines mitigates aerosolized Venezuelan equine encephalitis virus disease in cynomolgus macaques

单剂量纯化的来自转基因牛的人类抗体可减轻食蟹猴气溶胶感染的委内瑞拉马脑炎病毒疾病。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0347864

Sun, Chengqun; Gardner, Christina; Lam, Long Kwan Metthew; Lundy, Jeneveve; O'Malley, Katherine; Luke, Thomas; Raviprakash, Kanakatte; Hartman, Amy L; Crossland, Nicholas A; Wu, Hua; Jiao, Jin-An; Bausch, Christoph; Sullivan, Eddie; Reed, Douglas S; Klimstra, William B

发表日期：2026

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Structural basis for plasticity in receptor engagement by an encephalitic alphavirus.

脑炎甲病毒受体结合可塑性的结构基础

影响因子:42.5

doi:10.1016/j.cell.2025.02.036

Raju Saravanan, Palakurty Sathvik, Sariol Alan, Wagoner Ngan, Adams Lucas J, Hui Sean, Klimstra William B, Fremont Daved H, Diamond Michael S

免疫/内分泌

发表日期：2025

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Structural elucidation of a unique binding mode by an intact alphavirus human IgG molecule to a quaternary epitope

完整甲病毒人IgG分子与四级表位独特结合模式的结构解析

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-60505-x

Bandyopadhyay, Abhishek; Williamson, Lauren E; Sirohi, Devika; Bailey, Kevin; Gilliland, Theron Jr; Klose, Thomas; Buda, Geeta; Trivette, Andrew; Sun, Chengqun; Julander, Justin G; Klimstra, William B; Crowe, James E Jr; Kuhn, Richard J

发表日期：2025

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An inactivated trivalent virion-based vaccine protects against aerosol challenge with encephalitic alphaviruses in mice and macaques

一种基于灭活三价病毒颗粒的疫苗可保护小鼠和猕猴免受脑炎甲病毒气溶胶攻击。

期刊:Science Translational Medicine

影响因子:14.6

doi:10.1126/scitranslmed.adv7079

Lam, L K Metthew; Gilliland, Theron Jr; Dunn, Matthew; Alcorn-Burckhardt, Maria D; Terada, Yutaka; Sun, Chengqun; Vasilatos, Shauna; Midgett, Morgan; Williams, Connor; Laughlin, Amanda; Lundy, Jeneveve; Gardner, Christina L; Thomas, Archana; Raué, Hans-Peter; Gertje, Hans P; O'Connell, Aoife K; Crossland, Nicholas A; Reed, Douglas S; Diamond, Michael S; Slifka, Mark K; Klimstra, William B

发表日期：2025

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A detailed kinetic model of Eastern equine encephalitis virus replication in a susceptible host cell

易感宿主细胞内东部马脑炎病毒复制的详细动力学模型

期刊:PLoS Computational Biology

影响因子:3.6

doi:10.1371/journal.pcbi.1013082

Larkin, Caroline I; Dunn, Matthew D; Shoemaker, Jason E; Klimstra, William B; Faeder, James R

细胞生物学

发表日期：2025

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Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus.

东部马脑炎病毒利用VLDLR的结构和功能基础

影响因子:42.5

doi:10.1016/j.cell.2023.11.031

Adams Lucas J, Raju Saravanan, Ma Hongming, Gilliland Theron Jr, Reed Douglas S, Klimstra William B, Fremont Daved H, Diamond Michael S

免疫/内分泌

发表日期：2024

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No evidence for enhanced disease with human polyclonal SARS-CoV-2 antibody in the ferret model

在雪貂模型中，未发现人源多克隆SARS-CoV-2抗体可加重疾病的证据。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0290909

Reed, Douglas S; McElroy, Anita K; Barbeau, Dominique J; McMillen, Cynthia M; Tilston-Lunel, Natasha L; Nambulli, Shamkumar; Cottle, Emily; Gilliland, Theron C; Rannulu, Hasala; Lundy, Jeneveve; Olsen, Emily L; O'Malley, Katherine J; Xia, Mengying; Hartman, Amy L; Luke, Thomas C; Egland, Kristi; Bausch, Christoph; Wu, Hua; Sullivan, Eddie J; Klimstra, William B; Duprex, W Paul

发表日期：2024

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Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection

东部马脑炎病毒E2糖蛋白上的三个带正电荷的结合位点协调依赖于硫酸乙酰肝素和蛋白质受体的感染。

doi:10.1101/2024.11.04.621500

Alcorn, Maria D H; Sun, Chengqun; Gilliland, Theron C Jr; Lukash, Tetyana; Crasto, Christine M; Raju, Saravanan; Diamond, Michael S; Weaver, Scott C; Klimstra, William B

发表日期：2024

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Phagocyte-expressed glycosaminoglycans promote capture of alphaviruses from the blood circulation in a host species-specific manner

吞噬细胞表达的糖胺聚糖以宿主物种特异性的方式促进从血液循环中捕获甲病毒。

doi:10.1101/2023.08.09.552690

Ander, Stephanie E; Parks, M Guston; Davenport, Bennett J; Li, Frances S; Bosco-Lauth, Angela; Carpentier, Kathryn S; Sun, Chengqun; Lucas, Cormac J; Klimstra, William B; Ebel, Gregory D; Morrison, Thomas E

细胞生物学

发表日期：2023

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