日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry

氢氘交换质谱法揭示小分子对多种淀粉样蛋白免疫球蛋白轻链的稳定作用

期刊:
影响因子:
doi:10.64898/2026.01.07.698275
Peterle, Daniele; Yan, Nicholas L; Klimtchuk, Elena S; Wales, Thomas E; Gursky, Olga; Kelly, Jeffery W; Engen, John R; Morgan, Gareth J
免疫/内分泌
发表日期：2026
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An unusual phenotype of hereditary AApoAI amyloidosis caused by a novel Asp20Tyr substitution is linked to pH-dependent aggregation of apolipoprotein A-I

一种由新型Asp20Tyr突变引起的遗传性AApoAI淀粉样变性异常表型与载脂蛋白AI的pH依赖性聚集有关。

期刊:Biochimica et Biophysica Acta-Molecular Basis of Disease
影响因子:4.2
doi:10.1016/j.bbadis.2025.167820
Prokaeva, Tatiana; Jayaraman, Shobini; Klimtchuk, Elena; Burke, Natasha; Spencer, Brian; Nedelkov, Dobrin; Chen, Hui; Dasari, Surendra; McPhail, Ellen D; Pereira, Lucas; Payne, Michael C; Wong, Sherry; Burks, Eric J; Sanchorawala, Vaishali; Gursky, Olga
发表日期：2025
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Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis

免疫球蛋白G轻链恒定区和游离轻链的构象差异可能影响AL淀粉样变性中的蛋白水解

期刊:Journal of Molecular Biology
影响因子:4.5
doi:10.1016/j.jmb.2024.168837
Klimtchuk, Elena S; Prokaeva, Tatiana; Spencer, Brian H; Wong, Sherry; Ghosh, Shreya; Urdaneta, Angela; Morgan, Gareth; Wales, Thomas E; Gursky, Olga
免疫/内分泌
发表日期：2024
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Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition

心脏AL淀粉样变性患者（无明显淀粉样蛋白原纤维沉积）存在异常的整体纵向应变和血清炎症标志物降低。

期刊:
影响因子:
doi:10.1101/2024.03.14.584987
Edwards, Camille V; Ferri, Grace M; Villegas-Galaviz, Josue; Ghosh, Sabrina; Bawa, Pushpinder Singh; Wang, Feiya; Klimtchuk, Elena; Ajayi, Tinuola B; Morgan, Gareth J; Prokaeva, Tatiana; Staron, Andrew; Ruberg, Frederick L; Sanchorawala, Vaishali; Giadone, Richard M; Murphy, George J
炎症
炎症/感染
发表日期：2024
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Role of complementarity-determining regions 1 and 3 in pathologic amyloid formation by human immunoglobulin κ1 light chains

互补决定区1和3在人类免疫球蛋白κ1轻链病理性淀粉样蛋白形成中的作用

期刊:Amyloid-Journal of Protein Folding Disorders
影响因子:7.4
doi:10.1080/13506129.2023.2212397
Klimtchuk, Elena S; Peterle, Daniele; Bullitt, Esther; Connors, Lawreen H; Engen, John R; Gursky, Olga
免疫/内分泌
发表日期：2023
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A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin λ6 Light Chain Promotes Pathologic Amyloid Formation

人类免疫球蛋白λ6轻链动态抗原结合环中的保守点突变促进病理性淀粉样蛋白的形成

期刊:Journal of Molecular Biology
影响因子:4.5
doi:10.1016/j.jmb.2021.167310
Peterle, Daniele; Klimtchuk, Elena S; Wales, Thomas E; Georgescauld, Florian; Connors, Lawreen H; Engen, John R; Gursky, Olga
Human
免疫/内分泌
发表日期：2021
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Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease

人类转甲状腺素蛋白表面环中一种不寻常的重复突变会导致一种侵袭性强、耐药性高的淀粉样变性疾病。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1802977115
Klimtchuk, Elena S; Prokaeva, Tatiana; Frame, Nicholas M; Abdullahi, Hassan A; Spencer, Brian; Dasari, Surendra; Cui, Haili; Berk, John L; Kurtin, Paul J; Connors, Lawreen H; Gursky, Olga
免疫/内分泌
发表日期：2018
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In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis

人淀粉样变性免疫球蛋白轻链和重链蛋白的体外共表达：一种相关的基于细胞的AL淀粉样变性模型

期刊:Amyloid-Journal of Protein Folding Disorders
影响因子:7.4
doi:10.1080/13506129.2017.1336996
Klimtchuk, Elena S; Prokaeva, Tatiana B; Spencer, Brian H; Gursky, Olga; Connors, Lawreen H
细胞生物学
免疫/内分泌
发表日期：2017
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Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited

人肝脂肪酸结合蛋白的溶液结构和骨架动力学：脂肪酸结合再探

期刊:Biophysical Journal
影响因子:3.1
doi:10.1016/j.bpj.2012.04.039
Cai, Jun; Lücke, Christian; Chen, Zhongjing; Qiao, Ye; Klimtchuk, Elena; Hamilton, James A
代谢
发表日期：2012
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The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation

半胱氨酸10加合物和药物二氟尼柳对转甲状腺素四聚体稳定性的调节作用。荧光检测分析超速离心法直接分析。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M709638200
Kingsbury, Jonathan S; Laue, Thomas M; Klimtchuk, Elena S; Théberge, Roger; Costello, Catherine E; Connors, Lawreen H
IF
免疫/内分泌
发表日期：2008
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