日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition

Hippo 和 MAPK 通路激活之间的协同作用推动了对 TEAD 抑制的获得性抗性

Sayantanee Paul, Thijs J Hagenbeek #, Julien Tremblay #, Vasumathi Kameswaran, Christy Ong, Chad Liu, Alissa D Guarnaccia, James A Mondo, Peter L Hsu, Noelyn M Kljavin, Bartosz Czech, Janina Smola, Dieu An H Nguyen, Jennifer A Lacap, Trang H Pham, Yuxin Liang, Robert A Blake, Luca Gerosa, Matthew Gr

TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway

靶向TEAD的小分子诱导辅因子转换,从而调节Hippo通路。

Guarnaccia, Alissa D; Hagenbeek, Thijs J; Lee, Wendy; Kljavin, Noelyn; Choi, Meena; Tombling, Benjamin; Peukert, Carsten; Ulas, Gözde; Kameswaran, Vasumathi; Le, Daniel; Paul, Sayantanee; Vaidya, Samir; Zbieg, Jason R; Crawford, James J; Daniel, Bence; Dey, Anwesha; Lill, Jennie R

Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer

肿瘤细胞内自噬基因Atg16l1的表达抑制结直肠癌的抗肿瘤免疫

Lucia Taraborrelli # ,Yasin Şenbabaoğlu # ,Lifen Wang # ,Junghyun Lim ,Kerrigan Blake ,Noelyn Kljavin ,Sarah Gierke ,Alexis Scherl ,James Ziai ,Erin McNamara ,Mark Owyong ,Shilpa Rao ,Aslihan Karabacak Calviello ,Daniel Oreper ,Suchit Jhunjhunwala ,Guillem Argiles ,Johanna Bendell ,Tae Won Kim ,Fortunato Ciardiello ,Matthew J Wongchenko ,Frederic J de Sauvage ,Felipe de Sousa E Melo ,Yibing Yan ,Nathaniel R West ,Aditya Murthy

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

干细胞微环境特异性R-spondin 3表达的破坏会导致造血功能受损

Kurtova, Antonina V; Heinlein, Melanie; Haas, Simon; Velten, Lars; Dijkgraaf, Gerrit J P; Storm, Elaine E; Kljavin, Noelyn M; Boumahdi, Soufiane; Himmels, Patricia; Herault, Aurelie; Mancini, Andrew; Koeppen, Hartmut; Dail, Monique; Yan, Qingxiang; Zhang, Jianhuan; Koch, Ute; Radtke, Freddy; Modrusan, Zora; Metcalfe, Ciara; Piskol, Robert; de Sauvage, Frederic J

TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery From DNA Damage

TEAD 蛋白与 DNA 修复蛋白结合,促进细胞从 DNA 损伤中恢复

Philamer C Calses, Victoria C Pham, Alissa D Guarnaccia, Meena Choi, Erik Verschueren, Sietske T Bakker, Trang H Pham, Trent Hinkle, Chad Liu, Matthew T Chang, Noelyn Kljavin, Corey Bakalarski, Benjamin Haley, Jianing Zou, Cuicui Yan, Xia Song, Xiaoyan Lin, Rebecca Rowntree, Alan Ashworth, Anwesha D

Antibody targeting of E3 ubiquitin ligases for receptor degradation

抗体靶向E3泛素连接酶以降解受体

Hadir Marei # ,Wen-Ting K Tsai # ,Yee-Seir Kee # ,Karen Ruiz ,Jieyan He ,Chris Cox ,Tao Sun ,Sai Penikalapati ,Pankaj Dwivedi ,Meena Choi ,David Kan ,Pablo Saenz-Lopez ,Kristel Dorighi ,Pamela Zhang ,Yvonne T Kschonsak ,Noelyn Kljavin ,Dhara Amin ,Ingrid Kim ,Andrew G Mancini ,Thao Nguyen ,Chunling Wang ,Eric Janezic ,Alexander Doan ,Elaine Mai ,Hongkang Xi ,Chen Gu ,Melanie Heinlein ,Brian Biehs ,Jia Wu ,Isabelle Lehoux ,Seth Harris ,Laetitia Comps-Agrar ,Dhaya Seshasayee ,Frederic J de Sauvage ,Matthew Grimmer ,Jing Li ,Nicholas J Agard ,Felipe de Sousa E Melo

Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation

血清氨基酸升高会诱导 α 细胞亚群引发胰腺神经内分泌肿瘤的形成

Derek K Smith, Lance Kates, Steffen Durinck, Nisha Patel, Eric W Stawiski, Noelyn Kljavin, Oded Foreman, Bence Sipos, Mark J Solloway, Bernard B Allan, Andrew S Peterson

S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis

Pik3caH1047R;Trp53R270H;MMTV-Cre 驱动的乳腺肿瘤中的 S100a4 上调促进转移

Wenlin Yuan, Leonard D Goldstein, Steffen Durinck, Ying-Jiun Chen, Thong T Nguyen, Noelyn M Kljavin, Ethan S Sokol, Eric W Stawiski, Benjamin Haley, James Ziai, Zora Modrusan, Somasekar Seshagiri

Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations

可操作的激活致癌 ERBB2/HER2 跨膜和近膜结构域突变

Kanika Bajaj Pahuja, Thong T Nguyen, Bijay S Jaiswal, Kumar Prabhash, Tarjani M Thaker, Kate Senger, Subhra Chaudhuri, Noelyn M Kljavin, Aju Antony, Sameer Phalke, Prasanna Kumar, Marco Mravic, Eric W Stawiski, Derek Vargas, Steffen Durinck, Ravi Gupta, Arati Khanna-Gupta, Sally E Trabucco, Ethan S

Stem cell plasticity enables hair regeneration following Lgr5+ cell loss

干细胞可塑性使 Lgr5+ 细胞丢失后毛发再生

Joerg D Hoeck, Brian Biehs, Antonina V Kurtova, Noelyn M Kljavin, Felipe de Sousa E Melo, Bruno Alicke, Hartmut Koeppen, Zora Modrusan, Robert Piskol, Frederic J de Sauvage