日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An Adcy3 coding mutation causes partial loss of enzymatic function, contributing to obesity in a rat model by reducing lipolysis

Adcy3 编码突变导致酶功能部分丧失,通过降低脂肪分解作用,在大鼠模型中引起肥胖。

Fitzpatrick, Mackenzie K; Seshie, Osborne; Scott, Christina; Vora, Anusha; Seramur, Mary E; Beeson, Angela; Adrian, Leighelle; Grzybowski, Michael; Klotz, Jason; Geurts, Aron M; Key, Chia-Chi Chuang; Woods, Leah C Solberg

A Mutation in the Transmembrane Domain of Adenylate Cyclase 3 Impairs Enzymatic Function to Cause Sex-Specific Depression- and Anxiety-Like Behaviors and Food Seeking in a Rat Model.

腺苷酸环化酶 3 跨膜结构域的突变会损害酶功能,导致大鼠模型出现性别特异性的抑郁和焦虑样行为以及觅食行为

Fitzpatrick Mackenzie K, Dyson Christina, Beeson Angela, Adrian Leighelle, Marrs Glen, Grzybowski Michael, Klotz Jason, Geurts Aron M, Chen Rong, Weiner Jeffrey L, Solberg Woods Leah C

A mutation in the transmembrane domain of Adenylate cyclase 3 impairs enzymatic function to cause sex-specific depression- and anxiety-like behaviors and food seeking in a rat model

腺苷酸环化酶3跨膜结构域的突变会损害酶功能,导致大鼠模型出现性别特异性的抑郁和焦虑样行为以及觅食行为。

Fitzpatrick, Mackenzie K; Dyson, Christina; Beeson, Angela; Adrian, Leighelle; Marrs, Glen; Grzybowski, Michael; Klotz, Jason; Geurts, Aron M; Chen, Rong; Weiner, Jeffrey L; Solberg Woods, Leah C

Protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors sex-dependently in rats

Adcy3蛋白编码突变会增加大鼠的脂肪堆积并改变其情绪行为,且这种改变具有性别依赖性。

Fitzpatrick, Mackenzie K; Szalanczy, Alexandria; Beeson, Angela; Vora, Anusha; Scott, Christina; Grzybowski, Michael; Klotz, Jason; Der, Nataley; Chen, Rong; Geurts, Aron M; Solberg Woods, Leah C

Genetic Disruption of System xc-Mediated Glutamate Release from Astrocytes Increases Negative-Outcome Behaviors While Preserving Basic Brain Function in Rat

基因破坏系统xc介导的星形胶质细胞谷氨酸释放会增加大鼠的负面行为,但不会破坏其基本脑功能。

Hess, Evan M; Kassel, Sara N; Simandl, Gregory; Raddatz, Nicholas; Maunze, Brian; Hurley, Matthew M; Grzybowski, Michael; Klotz, Jason; Geurts, Aron; Liu, Qing-Song; Choi, SuJean; Twining, Robert C; Baker, David A

Keratinocyte-associated protein 3 plays a role in body weight and adiposity with differential effects in males and females

角质细胞相关蛋白3在体重和脂肪含量中发挥作用,但对男性和女性的影响不同。

Szalanczy, Alexandria M; Goff, Emily; Seshie, Osborne; Deal, Aaron; Grzybowski, Michael; Klotz, Jason; Chuang Key, Chia-Chi; Geurts, Aron M; Solberg Woods, Leah C