Klugmann相关文献与解析，生知库 | 链接生命科学的每一步

Vector-Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity-Clamped Gene Electrotransfer.

通过单电容放电电导钳位基因电转移实现无载体深层组织靶向DNA/RNA疗法

doi:10.1002/advs.202406545

Pinyon Jeremy L, von Jonquieres Georg, Mow Stephen L, Abed Amr Al, Lai Keng-Yin, Manoharan Mathumathi, Crawford Edward N, Xue Stanley H, Smith-Moore Sarah, Caproni Lisa J, Milsom Sarah, Klugmann Matthias, Lovell Nigel H, Housley Gary D

其它

发表日期：2025

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Engineering oxypurinol-responsive riboswitches based on bacterial xanthine aptamers for gene expression control in mammalian cell culture

基于细菌黄嘌呤适体的氧嘌呤醇响应核糖开关工程化用于哺乳动物细胞培养中的基因表达控制

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkae1189

Hedwig, Vera; Spöring, Maike; Ottlinger, Julia; Köse, Sila; Nar, Herbert; Schnapp, Gisela; Gottschling, Dirk; Klein, Holger; Aspnes, Gary; Klugmann, Matthias; Hartig, Jörg S

Preclinical development of TAK-754, a high-performance AAV8-based vector expressing coagulation factor VIII

TAK-754 的临床前开发，TAK-754 是一种基于 AAV8 的高性能载体，可表达凝血因子 VIII

期刊:Molecular Therapy-Methods & Clinical Development

影响因子:4.7

doi:10.1016/j.omtm.2025.101424

Lengler, Johannes; Weiller, Markus; Horling, Franziska; Mayrhofer, Josef; Schuster, Maria; Falkner, Falko G; Gil-Farina, Irene; Klugmann, Matthias; Scheiflinger, Friedrich; Hoellriegl, Werner; Rottensteiner, Hanspeter

发表日期：2025

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Gene Electrotransfer via Conductivity-Clamped Electric Field Focusing Pivots Sensori-Motor DNA Therapeutics: "A Spoonful of Sugar Helps the Medicine Go Down"

利用电导钳制电场聚焦进行基因电转移，为感觉运动DNA疗法带来转机：“一勺糖能让药更容易下咽”

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202401392

Pinyon, Jeremy L; von Jonquieres, Georg; Crawford, Edward N; Abed, Amr Al; Power, John M; Klugmann, Matthias; Browne, Cherylea J; Housley, David M; Wise, Andrew K; Fallon, James B; Shepherd, Robert K; Lin, John Y; McMahon, Catherine; McAlpine, David; Birman, Catherine S; Lai, Waikong; Enke, Ya Lang; Carter, Paul M; Patrick, James F; Gay, Robert D; Marie, Corinne; Scherman, Daniel; Lovell, Nigel H; Housley, Gary D

发表日期：2024

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Riboswitch-controlled IL-12 gene therapy reduces hepatocellular cancer in mice

核糖开关控制的 IL-12 基因治疗可降低小鼠的肝细胞癌

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2024.1360063

Matthias J Düchs, Ramona F Kratzer, Pablo Vieyra-Garcia, Benjamin Strobel, Tanja Schönberger, Peter Groß, Ghaith Aljayyoussi, Aradhana Gupta, Isabel Lang, Holger Klein, Sandra Martinez Morilla, Stefan Hopf, John Park, Sebastian Kreuz, Matthias Klugmann #, Frederik H Igney #

TRPC Channels Activated by G Protein-Coupled Receptors Drive Ca(2+) Dysregulation Leading to Secondary Brain Injury in the Mouse Model

G蛋白偶联受体激活的TRPC通道驱动Ca(2+)失调，导致小鼠模型继发性脑损伤

期刊:Translational Stroke Research

影响因子:4.3

doi:10.1007/s12975-023-01173-1

Parmar, Jasneet; von Jonquieres, Georg; Gorlamandala, Nagarajesh; Chung, Brandon; Craig, Amanda J; Pinyon, Jeremy L; Birnbaumer, Lutz; Klugmann, Matthias; Moorhouse, Andrew J; Power, John M; Housley, Gary D

Recessive aminoacyl-tRNA synthetase disorders: lessons learned from in vivo disease models

隐性氨酰tRNA合成酶疾病：从体内疾病模型中汲取的经验教训

期刊:Frontiers in Neuroscience

影响因子:3.2

doi:10.3389/fnins.2023.1182874

Kalotay, Elizabeth; Klugmann, Matthias; Housley, Gary D; Fröhlich, Dominik

发表日期：2023

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Editorial: Myelin Repair: At the Crossing-Lines of Myelin Biology and Gene Therapy

社论：髓鞘修复：髓鞘生物学与基因治疗的交叉领域

期刊:Frontiers in Cellular Neuroscience

影响因子:4

doi:10.3389/fncel.2022.853742

Fröhlich, Dominik; Gessler, Dominic J; Klugmann, Matthias

Correction to: Developmental delay and late onset HBSL pathology in hypomorphic Dars1(M256L) mice

更正：Dars1(M256L)低表达小鼠的发育迟缓和迟发性HBSL病理

期刊:Neurochemical Research

影响因子:3.8

doi:10.1007/s11064-022-03602-3

Klugmann, Matthias; Kalotay, Elizabeth; Delerue, Fabien; Ittner, Lars M; Bongers, Andre; Yu, Josephine; Morris, Margaret J; Housley, Gary D; Fröhlich, Dominik

发育与干细胞

发表日期：2022

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Pioglitazone modulates metabolic adaptation and peripheral nerve regeneration after injury.

吡格列酮能够调节损伤后的代谢适应和周围神经再生。

Vector-Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity-Clamped Gene Electrotransfer.

通过单电容放电电导钳位基因电转移实现无载体深层组织靶向DNA/RNA疗法

Engineering oxypurinol-responsive riboswitches based on bacterial xanthine aptamers for gene expression control in mammalian cell culture

基于细菌黄嘌呤适体的氧嘌呤醇响应核糖开关工程化用于哺乳动物细胞培养中的基因表达控制

Preclinical development of TAK-754, a high-performance AAV8-based vector expressing coagulation factor VIII

TAK-754 的临床前开发，TAK-754 是一种基于 AAV8 的高性能载体，可表达凝血因子 VIII

Gene Electrotransfer via Conductivity-Clamped Electric Field Focusing Pivots Sensori-Motor DNA Therapeutics: "A Spoonful of Sugar Helps the Medicine Go Down"

利用电导钳制电场聚焦进行基因电转移，为感觉运动DNA疗法带来转机：“一勺糖能让药更容易下咽”

Riboswitch-controlled IL-12 gene therapy reduces hepatocellular cancer in mice

核糖开关控制的 IL-12 基因治疗可降低小鼠的肝细胞癌

TRPC Channels Activated by G Protein-Coupled Receptors Drive Ca(2+) Dysregulation Leading to Secondary Brain Injury in the Mouse Model

G蛋白偶联受体激活的TRPC通道驱动Ca(2+)失调，导致小鼠模型继发性脑损伤

Recessive aminoacyl-tRNA synthetase disorders: lessons learned from in vivo disease models

隐性氨酰tRNA合成酶疾病：从体内疾病模型中汲取的经验教训

Editorial: Myelin Repair: At the Crossing-Lines of Myelin Biology and Gene Therapy

社论：髓鞘修复：髓鞘生物学与基因治疗的交叉领域

Correction to: Developmental delay and late onset HBSL pathology in hypomorphic Dars1(M256L) mice

更正：Dars1(M256L)低表达小鼠的发育迟缓和迟发性HBSL病理