日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Highly specific intracellular ubiquitination of a small molecule.

小分子的高度特异性细胞内泛素化。

Li Weicheng, Garcia-Rivera Enrique M, Mitchell Dylan C, Chick Joel M, Maetani Micah, Bhadoria Rohit, Knapp John M, Misu Ryosuke, Matthews Geoffrey M, Shirasaki Ryosuke, de Matos Simoes Ricardo, Viswanathan Vasanthi, Pulice John L, Rees Matthew G, Roth Jennifer A, Gygi Steven P, Mitsiades Constantine S, Kadoch Cigall, Schreiber Stuart L, Ostrem Jonathan M L

Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides

作者更正:由脱氧寡核苷酸编码的多样性导向合成

Hudson, Liam; Mason, Jeremy W; Westphal, Matthias V; Richter, Matthieu J R; Thielman, Jonathan R; Hua, Bruce K; Gerry, Christopher J; Xia, Guoqin; Osswald, Heather L; Knapp, John M; Tan, Zher Yin; Kokkonda, Praveen; Tresco, Ben I C; Liu, Shuang; Reidenbach, Andrew G; Lim, Katherine S; Poirier, Jennifer; Capece, John; Bonazzi, Simone; Gampe, Christian M; Smith, Nichola J; Bradner, James E; Coley, Connor W; Clemons, Paul A; Melillo, Bruno; Hon, C Suk-Yee; Ottl, Johannes; Dumelin, Christoph E; Schaefer, Jonas V; Faust, Ann Marie E; Berst, Frédéric; Schreiber, Stuart L; Zécri, Frédéric J; Briner, Karin

Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity

3,5-二取代吡咯并[2,3-b]吡啶作为具有抗病毒活性的衔接子相关激酶 1 抑制剂的合成及构效关系

Sven Verdonck, Szu-Yuan Pu, Fiona J Sorrell, Jon M Elkins, Mathy Froeyen, Ling-Jie Gao, Laura I Prugar, Danielle E Dorosky, Jennifer M Brannan, Rina Barouch-Bentov, Stefan Knapp, John M Dye, Piet Herdewijn, Shirit Einav, Steven De Jonghe

Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3

鉴定抑制促炎性 sPLA2-IIA 蛋白与整合素 αvβ3 相互作用的抑制剂

Ye, Long; Dickerson, Tiffany; Kaur, Handeep; Takada, Yoko K; Fujita, Masaaki; Liu, Ruiwu; Knapp, John M; Lam, Kit S; Schore, Neil E; Kurth, Mark J; Takada, Yoshikazu

Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions

利用双钯催化偶联反应进行高取代吲哚的多组分组装

Knapp, John M; Zhu, Jie S; Tantillo, Dean J; Kurth, Mark J

Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein

氰基喹啉类化合物与ΔF508囊性纤维化跨膜传导调节蛋白的校正-增强活性之间的构效关系

Knapp, John M; Wood, Alex B; Phuan, Puay-Wah; Lodewyk, Michael W; Tantillo, Dean J; Verkman, A S; Kurth, Mark J

Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates

利用高活性酰基烯酮和腈氧化物中间体的多组分大环化反应(MCMRs)

Knapp, John M; Fettinger, James C; Kurth, Mark J

Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis.

具有独立校正和增强活性的氰基喹啉可恢复囊性纤维化中 ΔPhe508-囊性纤维化跨膜电导调节剂氯离子通道的功能

Phuan Puay-Wah, Yang Baoxue, Knapp John M, Wood Alex B, Lukacs Gergely L, Kurth Mark J, Verkman A S

Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles

与联噻唑类化合物相比,吡唑基噻唑作为DeltaF508囊性纤维化跨膜电导调节剂具有更高的亲水性

Ye, Long; Knapp, John M; Sangwung, Panjamaporn; Fettinger, James C; Verkman, A S; Kurth, Mark J