日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

NEK7 phosphorylation of cortactin modulates the migratory capacity of cells expressing EML4-ALK V3.

NEK7 对 cortactin 的磷酸化调节表达 EML4-ALK V3 的细胞的迁移能力。

Richardson Emily L, Knebel Axel, Straatman Kees R, Gourlay Robert, Lamont Douglas, Hardy Tara, Turnbull Robert E, Robinson Susan W, O'Regan Laura, Bayliss Richard, Fry Andrew M

Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.

Ariadne-RBR E3 泛素连接酶对 co-E3 连接酶 DCNL1 的偶联单泛素化可促进 cullin-RING 连接酶复合物重塑

Kelsall Ian R, Kristariyanto Yosua A, Knebel Axel, Wood Nicola T, Kulathu Yogesh, Alpi Arno F

Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

Parkin-磷酸泛素复合物揭示了RBR连接酶活性所需的隐蔽泛素结合位点

Kumar, Atul; Chaugule, Viduth K; Condos, Tara E C; Barber, Kathryn R; Johnson, Clare; Toth, Rachel; Sundaramoorthy, Ramasubramanian; Knebel, Axel; Shaw, Gary S; Walden, Helen

Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

泛素C端水解酶可从结构蛋白中切割异肽键和肽键连接的泛素,但不能编辑泛素同聚物。

Bett, John S; Ritorto, Maria Stella; Ewan, Richard; Jaffray, Ellis G; Virdee, Satpal; Chin, Jason W; Knebel, Axel; Kurz, Thimo; Trost, Matthias; Tatham, Michael H; Hay, Ronald T

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

Parkin 的激活依赖于 PINK1 依赖的泛素 Ser65 位点的磷酸化。

Kazlauskaite, Agne; Kondapalli, Chandana; Gourlay, Robert; Campbell, David G; Ritorto, Maria Stella; Hofmann, Kay; Alessi, Dario R; Knebel, Axel; Trost, Matthias; Muqit, Miratul M K

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

TRIAD1 和 HHARI 与不同的 neddylated Cullin-RING 连接酶复合物结合并被其激活。

Kelsall, Ian R; Duda, David M; Olszewski, Jennifer L; Hofmann, Kay; Knebel, Axel; Langevin, Frédéric; Wood, Nicola; Wightman, Melanie; Schulman, Brenda A; Alpi, Arno F

UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation

UBXN7 利用其 UIM 基序与 NEDDylation 修饰的 cullin 复合物结合,导致 HIF1α 积累。

Bandau, Susanne; Knebel, Axel; Gage, Zoe O; Wood, Nicola T; Alexandru, Gabriela

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

PINK1 由线粒体膜电位去极化激活,并通过磷酸化丝氨酸 65 位点刺激 Parkin E3 连接酶活性。

Kondapalli, Chandana; Kazlauskaite, Agne; Zhang, Ning; Woodroof, Helen I; Campbell, David G; Gourlay, Robert; Burchell, Lynn; Walden, Helen; Macartney, Thomas J; Deak, Maria; Knebel, Axel; Alessi, Dario R; Muqit, Miratul M K

KESTREL: a powerful method for identifying the physiological substrates of protein kinases

KESTREL:一种用于鉴定蛋白激酶生理底物的强有力方法

Cohen, Philip; Knebel, Axel

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

应激激活蛋白激酶对CapZ相互作用蛋白(CapZIP)的磷酸化会触发其与CapZ的解离。

Eyers, Claire E; McNeill, Helen; Knebel, Axel; Morrice, Nick; Arthur, Simon J C; Cuenda, Ana; Cohen, Philip