日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Improving incretin-mediated body weight loss via energy expenditure

通过能量消耗改善肠促胰岛素介导的体重减轻

Elmendorf, Andrew J; Douros, Jonathan D; Knerr, Patrick J; Flak, Jonathan N

Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues

异位肝脏GLP-1R激动作用可增强GLP-1类似物的减肥效果。

Douros, Jonathan D; Capozzi, Megan; Novikoff, Aaron; Mokrosinski, Jacek; DuBois, Barent; Stock, Joseph; Rohlfs, Rebecca; Anderson, Mikayla; Jedrzejcyk, Dominika J; Poulsen, Svend; Blenke, Erik Oude; Dago, Tomas; Huus, Kasper; Nørby, Peder L; Kobberup, Sune; Rivir, Marita; Sorrell, Joyce; Mowery, Stephanie A; Drucker, Daniel J; D'Alessio, David A; Campbell, Jonathan E; Müller, Timo D; Perez-Tilve, Diego; Finan, Brian; Knerr, Patrick J

GCGR agonism requires GABAergic signaling in the medial basal hypothalamus to promote weight loss in obese mice.

GCGR激动剂需要下丘脑内侧基底核的GABA能信号传导才能促进肥胖小鼠的体重减轻。

Elmendorf Andrew J, Furber Ellen Conceição, Lorentz Betty, Mahler Connor A, Droz Brian A, Cosgrove Richard, Poret Jonquil Marie, Knerr Patrick J, Samms Ricardo J, Flak Jonathan N

Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

出版商更正:GIPR激动剂和拮抗剂通过不同的机制降低雄性小鼠的体重和食物摄入量。

Gutgesell, Robert M; Khalil, Ahmed; Liskiewicz, Arkadiusz; Maity-Kumar, Gandhari; Novikoff, Aaron; Grandl, Gerald; Liskiewicz, Daniela; Coupland, Callum; Karaoglu, Ezgi; Akindehin, Seun; Castelino, Russell; Curion, Fabiola; Liu, Xue; Garcia-Caceres, Cristina; Cebrian-Serrano, Alberto; Douros, Jonathan D; Knerr, Patrick J; Finan, Brian; DiMarchi, Richard D; Sloop, Kyle W; Samms, Ricardo J; Theis, Fabian J; Tschöp, Matthias H; Müller, Timo D

GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.

GIPR激动剂和拮抗剂通过不同的机制降低雄性小鼠的体重和食物摄入量

Gutgesell Robert M, Khalil Ahmed, Liskiewicz Arkadiusz, Maity-Kumar Gandhari, Novikoff Aaron, Grandl Gerald, Liskiewicz Daniela, Coupland Callum, Karaoglu Ezgi, Akindehin Seun, Castelino Russell, Curion Fabiola, Liu Xue, Garcia-Caceres Cristina, Cebrian-Serrano Alberto, Douros Jonathan D, Knerr Patrick J, Finan Brian, DiMarchi Richard D, Sloop Kyle W, Samms Ricardo J, Theis Fabian J, Tschöp Matthias H, Müller Timo D

Glucose-dependent insulinotropic polypeptide (GIP)

葡萄糖依赖性促胰岛素多肽(GIP)

Müller, Timo D; Adriaenssens, Alice; Ahrén, Bo; Blüher, Matthias; Birkenfeld, Andreas L; Campbell, Jonathan E; Coghlan, Matthew P; D'Alessio, David; Deacon, Carolyn F; DelPrato, Stefano; Douros, Jonathan D; Drucker, Daniel J; Figueredo Burgos, Natalie S; Flatt, Peter R; Finan, Brian; Gimeno, Ruth E; Gribble, Fiona M; Hayes, Matthew R; Hölscher, Christian; Holst, Jens J; Knerr, Patrick J; Knop, Filip K; Kusminski, Christine M; Liskiewicz, Arkadiusz; Mabilleau, Guillaume; Mowery, Stephanie A; Nauck, Michael A; Novikoff, Aaron; Reimann, Frank; Roberts, Anna G; Rosenkilde, Mette M; Samms, Ricardo J; Scherer, Philip E; Seeley, Randy J; Sloop, Kyle W; Wolfrum, Christian; Wootten, Denise; DiMarchi, Richard D; Tschöp, Matthias H

A once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans

每日一次的GLP-1/GIP/胰高血糖素受体三激动剂(NN1706)可降低啮齿动物、猴子和人类的体重。

Finan, Brian; Douros, Jonathan D; Goldwater, Ronald; Hansen, Ann Maria Kruse; Hjerpsted, Julie B; Hjøllund, Karina Rahr; Kankam, Martin K; Knerr, Patrick J; Konkar, Anish; Mowery, Stephanie A; Müller, Timo D; Nielsen, John Rømer; Nygård, Sune Boris; Perez-Tilve, Diego; Raun, Kirsten; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard D

A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice.

针对 cAMP 偏向信号传导优化的 GLP-1 类似物可改善肥胖小鼠的体重减轻

Douros Jonathan D, Novikoff Aaron, DuBois Barent, Rohlfs Rebecca, Mokrosinski Jacek, Hogendorf Wouter F J, Augustin Robert, Merkestein Myrte, Egaa Martini Lene Brandt, Linderoth Lars, Gerrard Elliot, Kodra Janos Tibor, Norlin Jenny, Roed Nikolaj Kulahin, Oldenburger Anouk, Mowery Stephanie A, Waldhoer Maria, Perez-Tilve Diego, Finan Brian, Reedtz-Runge Steffen, Müller Timo D, Knerr Patrick J

Acute exogenous acyl-GIP treatment enhances lipid handling and fatty acid oxidation by involving brown fat.

急性外源性酰基-GIP治疗通过棕色脂肪参与增强脂质处理和脂肪酸氧化。

Lyons Sulayman A, Lea Micah B S, Parikh Mihir, Guo Zhengzhang, Kagdi Samrin, Bisnauth Abigail R, Pitino Jonathan R, Ziai Sabrina, Mir Negar, Tyrrell Aidan D, Fu Yan, Chen Chuck T, Metherel Adam H, Bazinet Richard P, Yang Bin, Knerr Patrick J, Douros Jonathan D, Campbell Jonathan E, Beaudry Jacqueline L

The agony and the efficacy: central mechanisms of GLP-1 induced adverse events and their mitigation by GIP

痛苦与疗效:GLP-1诱导不良事件的核心机制及其通过GIP缓解的作用

Douros, Jonathan D; Flak, Jonathan N; Knerr, Patrick J