日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells

单分子成像揭示了Tau蛋白磷酸化如何影响其在活细胞中的运动和定位

Padmanabhan, Pranesh; Kneynsberg, Andrew; Cruz, Esteban; Briner, Adam; Götz, Jürgen

Tyrosine phosphatase STEP(61) in human dementia and in animal models with amyloid and tau pathology

酪氨酸磷酸酶 STEP(61) 在人类痴呆症和具有淀粉样蛋白和 tau 蛋白病理的动物模型中的作用

Taylor, Deonne; Kneynsberg, Andrew; van Roijen, Marloes; Götz, Jürgen

Single-molecule imaging reveals Tau trapping at nanometer-sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion

单分子成像显示,Tau蛋白被捕获在质膜附近纳米级的动态热点区域,这种捕获现象在微管扰动和胆固醇耗竭后仍然存在。

Padmanabhan, Pranesh; Kneynsberg, Andrew; Cruz, Esteban; Amor, Rumelo; Sibarita, Jean-Baptiste; Götz, Jürgen

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

tau蛋白病中的轴突变性:疾病相关性和潜在机制

Kneynsberg, Andrew; Combs, Benjamin; Christensen, Kyle; Morfini, Gerardo; Kanaan, Nicholas M

Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats.

衰老不影响 Fischer 344 大鼠海马神经元中 Tau 蛋白的轴突起始段结构和胞体定位

Kneynsberg Andrew, Kanaan Nicholas M

Tissue transglutaminase overexpression does not modify the disease phenotype of the R6/2 mouse model of Huntington's disease

组织转谷氨酰胺酶过表达不会改变亨廷顿病R6/2小鼠模型的疾病表型。

Kumar, Ashish; Kneynsberg, Andrew; Tucholski, Janusz; Perry, Giselle; van Groen, Thomas; Detloff, Peter J; Lesort, Mathieu

Mitochondrial calcium uptake capacity as a therapeutic target in the R6/2 mouse model of Huntington's disease

线粒体钙摄取能力作为亨廷顿病R6/2小鼠模型的治疗靶点

Perry, Giselle M; Tallaksen-Greene, Sara; Kumar, Ashish; Heng, Mary Y; Kneynsberg, Andrew; van Groen, Thomas; Detloff, Peter J; Albin, Roger L; Lesort, Mathieu