日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A high-throughput, quantitative platform using 2D dissociated human cerebral organoids to model neuroinflammation in Alzheimer's disease

利用二维分离的人类脑类器官构建高通量、定量平台,模拟阿尔茨海默病中的神经炎症

Olson, Meagan N; Barton, Nathaniel J; Feng, Luyao; Chigas, Samantha M; Tran, Khanh; Orszulak, Adrian R; Johnson, Jafira M; Dawes, Pepper; Shrestha, Chandani; Umaiyalan, Vishali R; Huang, Yen-Hsiang; Sundstrom, Jonathan; Murray, Liam F; Wang, Qi; Oh, Hyung Suk; Orzalli, Megan H; Knipe, David M; Readhead, Benjamin; Chan, Yingleong; Lim, Elaine T

Direct comparison of three herpes simplex virus-2 vaccine candidates using peripheral or mucosal routes of vaccination

直接比较三种单纯疱疹病毒2型候选疫苗(分别采用外周或黏膜接种途径)的疗效

Wang, Kening; Jordan, Tristan; Suzuki-Williams, Lui; Qin, Jing; Knipe, David M; Cohen, Jeffrey I

Next-generation replication-defective HSV vectors for delivery of large DNA payloads

用于递送大分子DNA载荷的新一代复制缺陷型HSV载体

Ingusci, Selene; Goins, William F; Cohen, Justus B; Miyagawa, Yoshitaka; Knipe, David M; Glorioso, Joseph C

Asymptomatic neonatal herpes simplex virus infection in mice leads to persistent CNS infection and long-term cognitive impairment

小鼠无症状新生儿单纯疱疹病毒感染会导致持续性中枢神经系统感染和长期认知障碍。

Dutton, Abigail J; Turnbaugh, Evelyn M; Patel, Chaya D; Garland, Callaghan R; Taylor, Sean A; Alers-Velazquez, Roberto; Knipe, David M; Nautiyal, Katherine M; Leib, David A

Validation of human sensory neurons derived from inducible pluripotent stem cells as a model for latent infection and reactivation by herpes simplex virus 1.

验证由诱导多能干细胞衍生的人类感觉神经元作为单纯疱疹病毒1型潜伏感染和再激活模型的有效性

Oh Hyung Suk, Chou Shu-Fan, Raja Priya, Shim Jaehoon, Das Biswajit, Pesola Jean M, Romero Nicolás, Lee Jennifer S, Ng Alex, Buttermore Elizabeth D, Church George, Woolf Clifford J, Coen Donald M, Knipe David M

Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency.

ICP34.5 对人类神经元中先天免疫反应的调节维持单纯疱疹病毒 1 型的潜伏状态。

Canova Paige N, Katzenell Sarah, Cerón Stacey, Charron Audra J, Pesola Jean M, Oh Hyung Suk, Coen Donald M, Knipe David M, Leib David A

Single‐cell spatial and non‐spatial RNA sequencing on herpes simplex virus 1 (HSV‐1) infected 2D and 3D cerebral organoids reveal molecular granularity on virus‐human gene interactions in Alzheimer’s disease

对单纯疱疹病毒1型(HSV-1)感染的二维和三维脑类器官进行单细胞空间和非空间RNA测序,揭示了阿尔茨海默病中病毒-人类基因相互作用的分子精细性

Barajas, Jonathan; Yang, Zhi; Agyare, Edward; Zhu, Xueyou; Yoon, Saun-Joo; Han, Bo; McClatchy, Daniel B; Labra, Sergio R; Baal, Christine; Lipton, Stuart A; Yates, John R III; Dawes, Pepper; Barton, Nathaniel J; Orszulak, Adrian R; Chigas, Samantha M; Tran, Khanh; Sundstrom, Jonathan; Olson, Meagan N; Murray, Liam F; Oh, HyungSuk; Church, George M; Knipe, David M; Readhead, Benjamin; Chan, Yingleong; Lim, Elaine T

Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases

单纯疱疹病毒1型感染人脑类器官和胰岛干细胞可驱动与阿尔茨海默病和自身免疫性疾病相关的类器官特异性转录本的表达

Sundstrom, Jonathan; Vanderleeden, Emma; Barton, Nathaniel J; Redick, Sambra D; Dawes, Pepper; Murray, Liam F; Olson, Meagan N; Tran, Khanh; Chigas, Samantha M; Orszulak, Adrian R; Church, George M; Readhead, Benjamin; Oh, Hyung Suk; Harlan, David M; Knipe, David M; Wang, Jennifer P; Chan, Yingleong; Lim, Elaine T

Comparison of the oncolytic activity of a replication-competent and a replication-deficient herpes simplex virus 1

比较具有复制能力和不具有复制能力的单纯疱疹病毒1的溶瘤活性

Lindner, Georg; Walter, Annika; Magnus, Clara L; Rosenhammer, Katharina; Holoborodko, Bohdan; Koch, Victoria; Hirsch, Sarah; Grossmann, Luis; Li, Suqi; Knipe, David M; DeLuca, Neal; Schuler-Thurner, Beatrice; Gross, Stefanie; Schwertner, Barbara; Toelge, Martina; Rohrhofer, Anette; Stöckl, Sabine; Bauer, Richard J; Knoll, Gertrud; Ehrenschwender, Martin; Haferkamp, Sebastian; Schmidt, Barbara; Schuster, Philipp

Blockade of innate inflammatory cytokines TNFα, IL-1β, or IL-6 overcomes virotherapy-induced cancer equilibrium to promote tumor regression

阻断先天性炎症细胞因子TNFα、IL-1β或IL-6可克服病毒疗法诱导的肿瘤平衡,从而促进肿瘤消退

Walsh, Michael J; Ali, Lestat R; Lenehan, Patrick; Kureshi, Courtney T; Kureshi, Rakeeb; Dougan, Michael; Knipe, David M; Dougan, Stephanie K