日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Clinical proof-of-concept results with a novel TRPA1 antagonist (LY3526318) in 3 chronic pain states

一种新型TRPA1拮抗剂(LY3526318)在3种慢性疼痛状态下的临床概念验证结果

Mellado Lagarde, Marcia M; Wilbraham, Darren; Martins, Ricardo Fonseca; Zhao, Heather Shi; Jackson, Kimberley; Johnson, Kirk W; Knopp, Kelly L; DiBenedetto, David; Broad, Lisa M

An innovative phase 2 chronic pain master protocol design to assess novel mechanisms in multiple pain types

一项创新的 II 期慢性疼痛总体方案设计,旨在评估多种疼痛类型的新机制

Knopp, Kelly L; Downing, AnnCatherine M; Anthony, Leslie; Chaterjee, Saptarshi; Price, Karen; Sparks, JonDavid

Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons

细胞外信号调节激酶介导炎症介质对背根神经节神经元复苏电流的增强作用

Wu, Bin; McDermott, Jeff S; Krajewski, Jeffrey L; Knopp, Kelly L; Nisenbaum, Eric S; Cummins, Theodore R; Tan, Zhi-Yong

Broad spectrum efficacy with LY2969822, an oral prodrug of metabotropic glutamate 2/3 receptor agonist LY2934747, in rodent pain models.

在啮齿动物疼痛模型中,LY2969822(代谢型谷氨酸 2/3 受体激动剂 LY2934747 的口服前药)具有广谱疗效

Johnson Michael P, Muhlhauser Mark A, Nisenbaum Eric S, Simmons Rosa M A, Forster Beth M, Knopp Kelly L, Yang Lijuan, Morrow Denise, Li Dominic L, Kennedy Jeffrey D, Swanson Steven, Monn James A

Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker

蛋白激酶C通过III-IV连接区中的丝氨酸残基增强人钠通道hNav1.7的复苏电流

Tan, Zhi-Yong; Priest, Birgit T; Krajewski, Jeffrey L; Knopp, Kelly L; Nisenbaum, Eric S; Cummins, Theodore R