日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization

生物分子凝聚体通过电荷中和作用在平衡状态下维持pH梯度。

Ausserwöger, Hannes; Scrutton, Rob; Fischer, Charlotte M; Sneideris, Tomas; Qian, Daoyuan; de Csilléry, Ella; Baronaite, Ieva; Saar, Kadi L; Białek, Alan Z; Oeller, Marc; Krainer, Georg; Franzmann, Titus M; Wittmann, Sina; Iglesias-Artola, Juan M; Invernizzi, Gaetano; Hyman, Anthony A; Alberti, Simon; Lorenzen, Nikolai; Knowles, Tuomas P J

Structural defects in amyloid-β fibrils drive secondary nucleation

淀粉样β纤维的结构缺陷驱动二级成核

Hu, Jing; Scheidt, Tom; Thacker, Dev; Axell, Emil; Stemme, Elin; Łapińska, Urszula; Wennmalm, Stefan; Meisl, Georg; Curk, Samo; Andreasen, Maria; Vendruscolo, Michele; Arosio, Paolo; Šarić, Anđela; Schmit, Jeremy D; Knowles, Tuomas P J; Sparr, Emma; Linse, Sara; Michaels, Thomas C T; Dear, Alexander J

Reversibility and β-sheet formation are decoupled in tau condensate aging

在 tau 凝聚体老化过程中,可逆性和 β 折叠的形成是解耦的。

Fischer, Charlotte M; Edu, Irina A; Šneideris, Tomas; Baronaite, Ieva; Toprakcioglu, Zenon; Deck, Leif-Thore; Qian, Daoyuan; Scrutton, Rob; Dreyer, Lasse; Wen, Jitao; Otzen, Daniel E; Wu, Si; Perrett, Sarah; Knowles, Tuomas P J

Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner

Tau蛋白以多晶型依赖的方式催化β-淀粉样蛋白的聚集和毒性。

Mosconi, Michele; Leonardi, Chiara; Armour-Garb, Zev; Rocutto, Beatrice; Beeg, Marten; Meisl, Georg; Ortigosa-Pascual, Lei; Broggini, Luca; Salmona, Mario; Ricagno, Stefano; Knowles, Tuomas P J; Diomede, Luisa

Oligomers mediate the spatial transmission of Aβ peptide aggregation

寡聚体介导Aβ肽聚集的空间传递

Peter, Quentin; Taylor, Chris; Lapinska, Urszula; Wei, Jiapeng; Michaels, Thomas C T; Arosio, Paolo; Linse, Sara; Knowles, Tuomas P J

Lipoengineering of Biomolecular Condensates Controls Material Properties and Multiphase Hierarchy to Guide Organoid Morphogenesis

生物分子凝聚体的脂质工程调控材料特性和多相层级结构,从而引导类器官形态发生

Huang, Zhiwei; Alam, Md Mahbubul; Shokri, Mahtab; Savitrinarayana, Harshavardhan C; Valappil, Sisila; Agarwal, Tanushree; Scrutton, Rob M; Maryam, Laiba; Gulzar, Asma; Wang, Jinying; Tigani, Dominic J; Pascoalino, Liege A; Jadhav, Akshay V; Adhya, Albert L; Bah, Alaji; Qin, Zhao; Shi, Zheng; Blatchley, Michael R; Chen, Jianhan; Knowles, Tuomas P J; Mozhdehi, Davoud

Diffusing protein binders to intrinsically disordered proteins.

将蛋白质结合剂扩散到固有无序蛋白质上

Liu Caixuan, Wu Kejia, Choi Hojun, Han Hannah L, Zhang Xueli, Watson Joseph L, Ahn Green, Zhang Jason Z, Shijo Sara, Good Lydia L, Fischer Charlotte M, Bera Asim K, Kang Alex, Brackenbrough Evans, Coventry Brian, Hick Derrick R, Qamar Seema, Li Xinting, Decarreau Justin, Gerben Stacey R, Yang Wei, Goreshnik Inna, Vafeados Dionne, Wang Xinru, Lamb Mila, Murray Analisa, Kenny Sebastian, Bauer Magnus S, Hoofnagle Andrew N, Zhu Ping, Knowles Tuomas P J, Baker David

PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning

PhaseXplorer 利用闭环主动学习创建高维相图

Jansen, Stef A H; Dreyer, Lasse S A; van Basten, Jule; Yao, Yihan; Otzen, Daniel E; de Greef, Tom F A; Knowles, Tuomas P J; Meijer, E W; Erkamp, Nadia A

The Liquid State of RIM1α and RBP Condensates is Maintained by Lipids

RIM1α和RBP凝聚体的液态是由脂质维持的。

Fischer, Charlotte M; Toprakcioglu, Zenon; de Csilléry, Ella; Kaminski Schierle, Gabriele S; Knowles, Tuomas P J

Quantifying collective interactions in biomolecular phase separation

量化生物分子相分离中的集体相互作用

Ausserwöger, Hannes; de Csilléry, Ella; Qian, Daoyuan; Krainer, Georg; Welsh, Timothy J; Sneideris, Tomas; Franzmann, Titus M; Qamar, Seema; Erkamp, Nadia A; Nixon-Abell, Jonathon; Kar, Mrityunjoy; St George-Hyslop, Peter; Hyman, Anthony A; Alberti, Simon; Pappu, Rohit V; Knowles, Tuomas P J