日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Substituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei

取代二苯醚作为对抗类鼻疽伯克霍尔德菌的新型化学治疗平台

Cummings, Jason E; Beaupre, Adam J; Knudson, Susan E; Liu, Nina; Yu, Weixuan; Neckles, Carla; Wang, Hui; Khanna, Avinash; Bommineni, Gopal R; Trunck, Lily A; Schweizer, Herbert P; Tonge, Peter J; Slayden, Richard A

Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor.

基于临床相关的烯酰-酰基载体蛋白(ACP)还原酶抑制剂的广谱抗菌活性的合理设计

Schiebel Johannes, Chang Andrew, Shah Sonam, Lu Yang, Liu Li, Pan Pan, Hirschbeck Maria W, Tareilus Mona, Eltschkner Sandra, Yu Weixuan, Cummings Jason E, Knudson Susan E, Bommineni Gopal R, Walker Stephen G, Slayden Richard A, Sotriffer Christoph A, Tonge Peter J, Kisker Caroline

Time-dependent diaryl ether inhibitors of InhA: structure-activity relationship studies of enzyme inhibition, antibacterial activity, and in vivo efficacy

InhA 的时间依赖性二芳醚抑制剂:酶抑制、抗菌活性和体内疗效的构效关系研究

Pan, Pan; Knudson, Susan E; Bommineni, Gopal R; Li, Huei-Jiun; Lai, Cheng-Tsung; Liu, Nina; Garcia-Diaz, Miguel; Simmerling, Carlos; Patil, Sachindra S; Slayden, Richard A; Tonge, Peter J

A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis.

一种对结核分枝杆菌有效的三取代苯并咪唑细胞分裂抑制剂

Knudson Susan E, Awasthi Divya, Kumar Kunal, Carreau Alexandra, Goullieux Laurent, Lagrange Sophie, Vermet Hélèn, Ojima Iwao, Slayden Richard A

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis

1,4-苯并恶嗪类MenB抑制剂的合成及构效关系研究:新型抗结核分枝杆菌抗菌剂

Li, Xiaokai; Liu, Nina; Zhang, Huaning; Knudson, Susan E; Slayden, Richard A; Tonge, Peter J

Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity

对土拉弗朗西斯菌FabI烯酰还原酶的缓释抑制:停留时间和体内活性

Lu, Hao; England, Kathleen; am Ende, Christopher; Truglio, James J; Luckner, Sylvia; Reddy, B Gopal; Marlenee, Nicole L; Knudson, Susan E; Knudson, Dennis L; Bowen, Richard A; Kisker, Caroline; Slayden, Richard A; Tonge, Peter J

Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors

B环修饰的二芳醚InhA抑制剂的合成及其体外抗分枝杆菌活性

am Ende, Christopher W; Knudson, Susan E; Liu, Nina; Childs, James; Sullivan, Todd J; Boyne, Melissa; Xu, Hua; Gegina, Yelizaveta; Knudson, Dennis L; Johnson, Francis; Peloquin, Charles A; Slayden, Richard A; Tonge, Peter J