文献库，生知库 | 链接生命科学的每一步

Combined statistical-biophysical modeling links ion channel genes to physiology of cortical neuron types

统计-生物物理联合建模将离子通道基因与皮层神经元类型的生理功能联系起来

doi:10.1101/2023.03.02.530774

Bernaerts, Yves; Deistler, Michael; Gonçalves, Pedro J; Beck, Jonas; Stimberg, Marcel; Scala, Federico; Tolias, Andreas S; Macke, Jakob; Kobak, Dmitry; Berens, Philipp

神经科学

发表日期：2025

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Principled PCA separates signal from noise in omics count data.

基于原理的主成分分析 (PCA) 可将组学计数数据中的信号与噪声分离

期刊:

影响因子:

doi:10.1101/2025.02.03.636129

Stanley Jay S 3rd, Yang Junchen, Li Ruiqi, Lindenbaum Ofir, Kobak Dmitry, Landa Boris, Kluger Yuval

信号转导

发表日期：2025

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The landscape of biomedical research

生物医学研究概况

期刊:Patterns

影响因子:7.4

doi:10.1016/j.patter.2024.100968

González-Márquez, Rita; Schmidt, Luca; Schmidt, Benjamin M; Berens, Philipp; Kobak, Dmitry

发表日期：2024

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The art of seeing the elephant in the room: 2D embeddings of single-cell data do make sense

洞察显而易见的问题：单细胞数据的二维嵌入确实有意义

期刊:PLoS Computational Biology

影响因子:3.6

doi:10.1371/journal.pcbi.1012403

Lause, Jan; Berens, Philipp; Kobak, Dmitry

Visualizing single-cell data with the neighbor embedding spectrum

利用邻域嵌入谱可视化单细胞数据

期刊:

影响因子:

doi:10.1101/2024.04.26.590867

Damrich, Sebastian; Klockow, Manuel V; Berens, Philipp; Hamprecht, Fred A; Kobak, Dmitry

Distinct organization of two cortico-cortical feedback pathways

两种皮层间反馈通路的不同组织结构

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-022-33883-9

Shen, Shan; Jiang, Xiaolong; Scala, Federico; Fu, Jiakun; Fahey, Paul; Kobak, Dmitry; Tan, Zhenghuan; Zhou, Na; Reimer, Jacob; Sinz, Fabian; Tolias, Andreas S

信号转导

发表日期：2022

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Analytic Pearson residuals for normalization of single-cell RNA-seq UMI data

用于单细胞 RNA-seq UMI 数据归一化的分析 Pearson 残差

期刊:Genome Biology

影响因子:9.4

doi:10.1186/s13059-021-02451-7

Lause, Jan; Berens, Philipp; Kobak, Dmitry

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset

利用世界死亡率数据集追踪新冠肺炎疫情期间各国超额死亡率

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.69336

Karlinsky, Ariel; Kobak, Dmitry

Representation learning of single-cell RNA-seq data

单细胞RNA测序数据的表征学习

Delving into LLM-assisted writing in biomedical publications through excess vocabulary

通过词汇过剩深入探讨LLM辅助的生物医学出版物写作

Combined statistical-biophysical modeling links ion channel genes to physiology of cortical neuron types

统计-生物物理联合建模将离子通道基因与皮层神经元类型的生理功能联系起来

Principled PCA separates signal from noise in omics count data.

基于原理的主成分分析 (PCA) 可将组学计数数据中的信号与噪声分离

The landscape of biomedical research

生物医学研究概况

The art of seeing the elephant in the room: 2D embeddings of single-cell data do make sense

洞察显而易见的问题：单细胞数据的二维嵌入确实有意义

Visualizing single-cell data with the neighbor embedding spectrum

利用邻域嵌入谱可视化单细胞数据

Distinct organization of two cortico-cortical feedback pathways

两种皮层间反馈通路的不同组织结构

Analytic Pearson residuals for normalization of single-cell RNA-seq UMI data

用于单细胞 RNA-seq UMI 数据归一化的分析 Pearson 残差

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset

利用世界死亡率数据集追踪新冠肺炎疫情期间各国超额死亡率