日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

SHIELD study: a multicenter, open-label, single-arm trial to evaluate the safety, pharmacokinetics and antiviral activity of fostemsavir in combination with optimized background therapy (OBT) in children and adolescents with HIV who are failing their current combination antiretroviral therapy (cART) and have dual- or triple-class antiretroviral (ARV) resistance

SHIELD 研究：一项多中心、开放标签、单臂试验，旨在评估福斯特沙韦联合优化背景疗法 (OBT) 在对当前联合抗逆转录病毒疗法 (cART) 治疗失败且存在双重或三重抗逆转录病毒 (ARV) 耐药性的 HIV 感染儿童和青少年中的安全性、药代动力学和抗病毒活性。

期刊:BMC Infectious Diseases
影响因子:3
doi:10.1186/s12879-026-12806-9
Grasa, Carlos; Salvadori, Nicolas; Nardone, Alessandra; Than-In-At, Kanchana; Koblansky, Alicia; Parry, Chris; Thakkar, Nilay; Wang, Marcia; Giaquinto, Carlo; Rojo, Pablo; Cressey, Tim R
HIV
炎症/感染
微生物学
发表日期：2026
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CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

CTLA-4 和 PD-1 双重阻断可诱导 SIV 再激活，且无法控制抗逆转录病毒治疗中断后的反弹。

期刊:Nature Medicine
影响因子:58.7
doi:10.1038/s41591-020-0782-y
Justin Harper ，Shari Gordon ，Chi Ngai Chan ，Hong Wang ，Emily Lindemuth ，Cristin Galardi ，Shane D Falcinelli ，Samuel L M Raines ，Jenna L Read ，Kevin Nguyen ，Colleen S McGary ，Michael Nekorchuk ，Kathleen Busman-Sahay ，James Schawalder ，Colin King ，Maria Pino ，Luca Micci ，Barbara Cervasi ，Sherrie Jean ，Andrew Sanderson ，Brian Johns ，A Alicia Koblansky ，Heather Amrine-Madsen ，Jeffrey Lifson ，David M Margolis ，Guido Silvestri ，Katharine J Bar ，David Favre ，Jacob D Estes ，Mirko Paiardini
PD-1
微生物学
发表日期：2020
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The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis

抑制性先天免疫传感器NLRP12通过调节肠道菌群稳态来维持对抗肥胖的阈值

期刊:Cell Host & Microbe
影响因子:20.6
doi:10.1016/j.chom.2018.08.009
Agnieszka D Truax ，Liang Chen ，Jason W Tam ，Ning Cheng ，Hao Guo ，A Alicia Koblansky ，Wei-Chun Chou ，Justin E Wilson ，W June Brickey ，Alex Petrucelli ，Rongrong Liu ，Daniel E Cooper ，Mark J Koenigsknecht ，Vincent B Young ，Mihai G Netea ，Rinke Stienstra ，R Balfour Sartor ，Stephanie A Montgomery ，Rosalind A Coleman ，Jenny P-Y Ting
代谢
免疫/内分泌
LRP1
微生物学
肠道菌群
NLRP1
肥胖
发表日期：2018
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The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals

先天免疫受体NLRX1通过减少结肠肿瘤发生和关键促肿瘤信号发挥抑癌作用

期刊:Cell Reports
影响因子:6.9
doi:10.1016/j.celrep.2016.02.064
Koblansky, A Alicia; Truax, Agnieszka D; Liu, Rongrong; Montgomery, Stephanie A; Ding, Shengli; Wilson, Justin E; Brickey, W June; Mühlbauer, Marcus; McFadden, Rita-Marie T; Hu, Peizhen; Li, Zengshan; Jobin, Christian; Lund, Pauline Kay; Ting, Jenny P-Y
信号转导
肿瘤
肿瘤免疫
免疫/内分泌
发表日期：2016
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Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

AIM2 通过 DNA-PK 和 Akt 抑制结肠肿瘤发生，发挥炎症小体独立作用

期刊:Nature Medicine
影响因子:58.7
doi:10.1038/nm.3908
Justin E Wilson, Alex S Petrucelli, Liang Chen, A Alicia Koblansky, Agnieszka D Truax, Yoshitaka Oyama, Arlin B Rogers, W June Brickey, Yuli Wang, Monika Schneider, Marcus Mühlbauer, Wei-Chun Chou, Brianne R Barker, Christian Jobin, Nancy L Allbritton, Dale A Ramsden, Beckley K Davis, Jenny P Y Ting
信号转导
肿瘤
肠癌
WB
PI3K/Akt
炎性小体
Bovine
IgG
发表日期：2015
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Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11

弓形虫原肌球蛋白的结构分析：Toll 样受体 11 识别需要寄生虫特异性基序

期刊:Journal of Molecular Biology
影响因子:4.7
doi:10.1016/j.jmb.2010.09.022
Kaury Kucera, A Alicia Koblansky, Lauren P Saunders, Kendra B Frederick, Enrique M De La Cruz, Sankar Ghosh, Yorgo Modis
信号转导
Toll-Like Receptor
发表日期：2010
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