Koch Pierre相关文献与解析，生知库 | 链接生命科学的每一步

Ertl, Fabian J; Friedel, Anna; Schmid, Elena J; Höring, Carina; Archipowa, Nataliya; Koch, Pierre; Maschauer, Simone; Kutta, Roger J; Prante, Olaf; Keller, Max

发表日期：2025

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A "Ligand First" Approach toward Selective, Covalent JNK2/3 Inhibitors.

以“配体优先”为导向的选择性共价 JNK2/3 抑制剂策略

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c00884

Wydra Valentin R, Plank Nicole, Zwirner Stefan, Selig Roland, Rasch Alexander, Masberg Benedikt, LÃ¤mmerhofer Michael, Zender Lars, Koch Pierre, Albrecht Wolfgang, Laufer Stefan

4-[5-(4-Fluoro-phen-yl)-1,2-oxazol-4-yl]pyridine

4-[5-(4-氟苯基)-1,2-噁唑-4-基]吡啶

期刊:IUCrdata

影响因子:

doi:10.1107/S2414314625009873

Koch, Pierre; Schollmeyer, Dieter; Laufer, Stefan

发表日期：2025

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A Defined Diet Combined with Sonicated Inoculum Provides a High Incidence, Moderate Severity Form of Experimental Autoimmune Encephalomyelitis (EAE).

特定饮食与超声处理的接种物相结合，可导致高发病率、中等严重程度的实验性自身免疫性脑脊髓炎 (EAE)

期刊:ACS Pharmacology and Translational Science

影响因子:3.7

doi:10.1021/acsptsci.4c00189

Martorelli Mariella, Dengler Matthias, Laux Julian, Fischer Tina, Vaiceliunaite Agne, Hahn Ulrike, Weinstein Thilo, Cruces Santiago, Pokoj Christina, de Oliveira da Cunha Luciano, Wohlbold Lara, Koch Pierre, Laufer Stefan, Burnet Michael, Maier Florian

免疫/内分泌

发表日期：2024

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Controlling the Covalent Reactivity of a Kinase Inhibitor with Light

利用光控制激酶抑制剂的共价反应性

期刊:Angewandte Chemie-International Edition

影响因子:16.9

doi:10.1002/anie.202103767

Reynders, Martin; Chaikuad, Apirat; Berger, Benedict-Tilman; Bauer, Katharina; Koch, Pierre; Laufer, Stefan; Knapp, Stefan; Trauner, Dirk

信号转导

发表日期：2021

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Genetic Engineering in Combination with Semi-Synthesis Leads to a New Route for Gram-Scale Production of the Immunosuppressive Natural Product Brasilicardin A

基因工程与半合成相结合，为克级规模生产免疫抑制天然产物巴西卡汀A开辟了新途径

期刊:Angewandte Chemie-International Edition

影响因子:16.9

doi:10.1002/anie.202015852

Botas, Alma; Eitel, Michael; Schwarz, Paul N; Buchmann, Anina; Costales, Paula; Núñez, Luz Elena; Cortés, Jesús; Morís, Francisco; Krawiec, Michał; Wolański, Marcin; Gust, Bertolt; Rodriguez, Mirna; Fischer, Wolf-Nicolas; Jandeleit, Bernd; Zakrzewska-Czerwińska, Jolanta; Wohlleben, Wolfgang; Stegmann, Evi; Koch, Pierre; Méndez, Carmen; Gross, Harald

免疫/内分泌

发表日期：2021

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A novel LysR-type regulator negatively affects biosynthesis of the immunosuppressant brasilicardin

一种新型LysR型调节因子对免疫抑制剂巴西卡汀的生物合成具有负面影响。

期刊:Engineering in Life Sciences

影响因子:3

doi:10.1002/elsc.202000038

Wolański, Marcin; Krawiec, Michał; Schwarz, Paul N; Stegmann, Evi; Wohlleben, Wolfgang; Buchmann, Anina; Gross, Harald; Eitel, Michael; Koch, Pierre; Botas, Alma; Méndez, Carmen; Núñez, Luz Elena; Morís, Francisco; Cortés, Jesus; Zakrzewska-Czerwińska, Jolanta

免疫/内分泌

发表日期：2021

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1-{3-[(7-Fluoro-9H-pyrimido[4,5-b]indol-4-yl)(meth-yl)amino]-piperidin-1-yl}propan-1-one

1-{3-[(7-氟-9H-嘧啶并[4,5-b]吲哚-4-基)(甲基)氨基]-哌啶-1-基}丙-1-酮

期刊:IUCrdata

影响因子:

doi:10.1107/S2414314621001590

Andreev, Stanislav; Schollmeyer, Dieter; Koch, Pierre

发表日期：2021

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(2S,3'S,3a'R,5'R,7a'R)-5'-[(E)-5-(Furan-3-yl)-2-methyl-pent-1-en-1-yl]-3-hy-droxy-3',4,7'-trimethyl-1',2',3',3a',5',7a'-hexa-hydro-5H-spiro-[furan-2,4'-inden]-5-one

(2S,3'S,3a'R,5'R,7a'R)-5'-[(E)-5-(呋喃-3-基)-2-甲基-戊-1-烯-1-基]-3-羟基-3',4,7'-三甲基-1',2',3',3a',5',7a'-六氢-5H-螺-[呋喃-2,4'-茚]-5-酮

期刊:IUCrdata

影响因子:

doi:10.1107/S2414314620015783

Majer, Thomas; Schollmeyer, Dieter; Koch, Pierre; Gross, Harald

发表日期：2020

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Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3β Inhibitors

7-氯-9H-嘧啶并[4,5-b]吲哚类糖原合成酶激酶-3β抑制剂的设计、合成及生物学评价

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules24122331

Andreev, Stanislav; Pantsar, Tatu; Ansideri, Francesco; Kudolo, Mark; Forster, Michael; Schollmeyer, Dieter; Laufer, Stefan A; Koch, Pierre

信号转导

发表日期：2019

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High-Affinity and Proteolytically Stable Peptidic Fluorescent NTS(1)R Ligands

高亲和力且蛋白水解稳定的肽荧光NTS(1)R配体

A "Ligand First" Approach toward Selective, Covalent JNK2/3 Inhibitors.

以“配体优先”为导向的选择性共价 JNK2/3 抑制剂策略

4-[5-(4-Fluoro-phen-yl)-1,2-oxazol-4-yl]pyridine

4-[5-(4-氟苯基)-1,2-噁唑-4-基]吡啶

A Defined Diet Combined with Sonicated Inoculum Provides a High Incidence, Moderate Severity Form of Experimental Autoimmune Encephalomyelitis (EAE).

特定饮食与超声处理的接种物相结合，可导致高发病率、中等严重程度的实验性自身免疫性脑脊髓炎 (EAE)

Controlling the Covalent Reactivity of a Kinase Inhibitor with Light

利用光控制激酶抑制剂的共价反应性

Genetic Engineering in Combination with Semi-Synthesis Leads to a New Route for Gram-Scale Production of the Immunosuppressive Natural Product Brasilicardin A

基因工程与半合成相结合，为克级规模生产免疫抑制天然产物巴西卡汀A开辟了新途径

A novel LysR-type regulator negatively affects biosynthesis of the immunosuppressant brasilicardin

一种新型LysR型调节因子对免疫抑制剂巴西卡汀的生物合成具有负面影响。

1-{3-[(7-Fluoro-9H-pyrimido[4,5-b]indol-4-yl)(meth-yl)amino]-piperidin-1-yl}propan-1-one

1-{3-[(7-氟-9H-嘧啶并[4,5-b]吲哚-4-基)(甲基)氨基]-哌啶-1-基}丙-1-酮

(2S,3'S,3a'R,5'R,7a'R)-5'-[(E)-5-(Furan-3-yl)-2-methyl-pent-1-en-1-yl]-3-hy-droxy-3',4,7'-trimethyl-1',2',3',3a',5',7a'-hexa-hydro-5H-spiro-[furan-2,4'-inden]-5-one

(2S,3'S,3a'R,5'R,7a'R)-5'-[(E)-5-(呋喃-3-基)-2-甲基-戊-1-烯-1-基]-3-羟基-3',4,7'-三甲基-1',2',3',3a',5',7a'-六氢-5H-螺-[呋喃-2,4'-茚]-5-酮

Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3β Inhibitors

7-氯-9H-嘧啶并[4,5-b]吲哚类糖原合成酶激酶-3β抑制剂的设计、合成及生物学评价