AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation
AD相关的R47H-TREM2突变通过AKT过度激活诱导疾病增强的小胶质细胞状态
期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.abe3947
Sayed, Faten A; Kodama, Lay; Fan, Li; Carling, Gillian K; Udeochu, Joe C; Le, David; Li, Qingyun; Zhou, Lu; Wong, Man Ying; Horowitz, Rose; Ye, Pearly; Mathys, Hansruedi; Wang, Minghui; Niu, Xiang; Mazutis, Linas; Jiang, Xueqiao; Wang, Xueting; Gao, Fuying; Brendel, Matthew; Telpoukhovskaia, Maria; Tracy, Tara E; Frost, Georgia; Zhou, Yungui; Li, Yaqiao; Qiu, Yue; Cheng, Zuolin; Yu, Guoqiang; Hardy, John; Coppola, Giovanni; Wang, Fei; DeTure, Michael A; Zhang, Bin; Xie, Lei; Trajnowski, John Q; Lee, Virginia M Y; Gong, Shiaoching; Sinha, Subhash C; Dickson, Dennis W; Luo, Wenjie; Gan, Li