日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Towards directed therapy for fusion-positive rhabdomyosarcoma

针对融合阳性横纹肌肉瘤的定向治疗

Turco, George M; Oberoi, Sapna; Ladle, Brian; Raavi; Wagner, Lars; Koehler, Angela N; Linardic, Corinne M

Targeted degradation of CDK9 potently disrupts the MYC-regulated network.

靶向降解 CDK9 可有效破坏 MYC 调控网络

Toure Mohammed A, Motoyama Keisuke, Xiang Yichen, Urgiles Julie, Kabinger Florian, Koglin Ann-Sophie, Iyer Ramya S, Gagnon Kaitlyn, Kumar Amruth, Ojeda Samuel, Harrison Drew A, Rees Matthew G, Roth Jennifer A, Ott Christopher J, Schiavoni Richard, Whittaker Charles A, Levine Stuart S, White Forest M, Calo Eliezer, Richters Andre, Koehler Angela N

Small molecule modulators of TOX protein re-invigorate T cell activity

TOX蛋白的小分子调节剂可重新激活T细胞活性

Wu, Bocheng; Chang, Heng Jui; Singh, Prashant; Hostetler, Alexander; Xiang, Yichen; Guo, Shenghao; Wang, Fiona Yihan; Zhong, Julia J; Leifer, Becky S; Schiavoni, Richard P; Jiang, Nan; Choudhary, Amit; Westcott, Peter M K; Koehler, Angela N

New opportunities to overcome T cell dysfunction: the role of transcription factors and how to target them

克服T细胞功能障碍的新契机:转录因子的作用及其靶向治疗

Wu, Bocheng; Koehler, Angela N; Westcott, Peter M K

A Versatile Isocyanate-Mediated Strategy for Appending Chemical Tags onto Drug-Like Small Molecules

一种用途广泛的异氰酸酯介导策略,用于将化学标签连接到类药小分子上

Henry, Catherine C; Kruell, Jasmin A; Wilson, Robert M; Chang, Chia-Fu; Woo, Christina M; Koehler, Angela N

Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery

大规模并行混合筛选揭示了纳米颗粒递送的基因组决定因素

Boehnke, Natalie; Straehla, Joelle P; Safford, Hannah C; Kocak, Mustafa; Rees, Matthew G; Ronan, Melissa; Rosenberg, Danny; Adelmann, Charles H; Chivukula, Raghu R; Nabar, Namita; Berger, Adam G; Lamson, Nicholas G; Cheah, Jaime H; Li, Hojun; Roth, Jennifer A; Koehler, Angela N; Hammond, Paula T

Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors

对合理设计的强效BMX抑制剂共价结合模式的结构和生物物理学见解

Seixas, João D; Sousa, Bárbara B; Marques, Marta C; Guerreiro, Ana; Traquete, Rui; Rodrigues, Tiago; Albuquerque, Inês S; Sousa, Marcos F Q; Lemos, Ana R; Sousa, Pedro M F; Bandeiras, Tiago M; Wu, Di; Doyle, Shelby K; Robinson, Carol V; Koehler, Angela N; Corzana, Francisco; Matias, Pedro M; Bernardes, Gonçalo J L

Advances in discovering small molecules to probe protein function in a systems context

在系统背景下,利用小分子探测蛋白质功能的研究进展

Doyle, Shelby K; Pop, Marius S; Evans, Helen L; Koehler, Angela N

A Novel Small Molecule Activator of Nuclear Receptor SHP Inhibits HCC Cell Migration via Suppressing Ccl2

一种新型小分子核受体SHP激活剂通过抑制Ccl2抑制HCC细胞迁移

Yang, Zhihong; Koehler, Angela N; Wang, Li

Recent discoveries and applications involving small-molecule microarrays

小分子微阵列的最新发现和应用

Hong, Jiyoung A; Neel, Dylan V; Wassaf, Dina; Caballero, Francisco; Koehler, Angela N