日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A mechanistic biomarker investigation of fialuridine hepatotoxicity using the chimeric TK-NOG Hu-liver mouse model and in vitro micropatterned hepatocyte cocultures

利用嵌合TK-NOG Hu-liver小鼠模型和体外微图案化肝细胞共培养技术,对非拉尿苷肝毒性进行机制生物标志物研究

Aslamkhan, Amy G; Michna, Laura; Podtelezhnikov, Alexei; Vlasakova, Katerina; Suemizu, Hiroshi; Ohnishi, Yasuyuki; Liu, Liping; Lane, Pamela; Xu, Qiuwei; Kuhls, Matthew C; Wang, Zhibin; Pacchione, Stephen; Erdos, Zoltan; Tracy, Rodger William; Koeplinger, Kenneth; Muniappa, Nagaraja; Valentine, John; Galijatovic-Idrizbegovic, Alema; Glaab, Warren E; Sistare, Frank D; Lebron, Jose

Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor

口服生物可利用的大环肽,可抑制 PCSK9 与低密度脂蛋白受体的结合

Douglas G Johns #, Louis-Charles Campeau #, Puja Banka, An Bautmans, Tjerk Bueters, Elisabetta Bianchi, Danila Branca, Paul G Bulger, Inne Crevecoeur, Fa-Xiang Ding, Robert M Garbaccio, Erik D Guetschow, Yan Guo, Sookhee N Ha, Jennifer M Johnston, Hubert Josien, Eunkyung A Kauh, Kenneth A Koeplinger

Generation of SARS-CoV-2 reporter replicon for high-throughput antiviral screening and testing

构建用于高通量抗病毒筛选和检测的SARS-CoV-2报告基因复制子

He, Xi; Quan, Shuo; Xu, Min; Rodriguez, Silveria; Goh, Shih Lin; Wei, Jiajie; Fridman, Arthur; Koeplinger, Kenneth A; Carroll, Steve S; Grobler, Jay A; Espeseth, Amy S; Olsen, David B; Hazuda, Daria J; Wang, Dai

SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development

SARS-CoV-2 的嗜性、入侵、复制和传播:药物发现和开发中的考量

Murgolo, Nicholas; Therien, Alex G; Howell, Bonnie; Klein, Daniel; Koeplinger, Kenneth; Lieberman, Linda A; Adam, Gregory C; Flynn, Jessica; McKenna, Philip; Swaminathan, Gokul; Hazuda, Daria J; Olsen, David B

MK-7622: A First-in-Class M(1) Positive Allosteric Modulator Development Candidate

MK-7622:首创的M(1)正向变构调节剂候选药物

Beshore, Douglas C; N Di Marco, Christina; Chang, Ronald K; Greshock, Thomas J; Ma, Lei; Wittmann, Marion; Seager, Matthew A; Koeplinger, Kenneth A; Thompson, Charles D; Fuerst, Joy; Hartman, George D; Bilodeau, Mark T; Ray, William J; Kuduk, Scott D

Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators

鉴定酰胺类化合物作为喹诺里酮类m1正向变构调节剂的羧酸替代物

Kuduk, Scott D; Chang, Ronald K; Greshock, Thomas J; Ray, William J; Ma, Lei; Wittmann, Marion; Seager, Matthew A; Koeplinger, Kenneth A; Thompson, Charles D; Hartman, George D; Bilodeau, Mark T

Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators

喹诺里酮羧酸作为中枢神经系统穿透性选择性m1变构毒蕈碱受体调节剂

Kuduk, Scott D; Chang, Ronald K; Di Marco, Christina N; Ray, William J; Ma, Lei; Wittmann, Marion; Seager, Matthew A; Koeplinger, Kenneth A; Thompson, Charles D; Hartman, George D; Bilodeau, Mark T