日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes

蛋白质-蛋白质界面处的相互作用受阻在PROTAC三元复合物的协同作用中起着核心作用。

Ma, Ning; Bhattacharya, Supriyo; Muk, Sanychen; Jandova, Zuzana; Schmalhorst, Philipp S; Ghosh, Soumadwip; Le, Keith; Diers, Emelyne; Trainor, Nicole; Farnaby, William; Roy, Michael J; Kofink, Christiane; Greb, Peter; Weinstabl, Harald; Ciulli, Alessio; Bader, Gerd; Sankar, Kyra; Bergner, Andreas; Vaidehi, Nagarajan

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

Homo-BacPROTAC 诱导 ClpC1 降解作为对抗耐药分枝杆菌的策略

Lukas Junk #, Volker M Schmiedel #, Somraj Guha, Katharina Fischel, Peter Greb, Kristin Vill, Violetta Krisilia, Lasse van Geelen, Klaus Rumpel, Parvinder Kaur, Ramya V Krishnamurthy, Shridhar Narayanan, Radha Krishan Shandil, Mayas Singh, Christiane Kofink, Andreas Mantoulidis, Philipp Biber, Gerha

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

选择性且口服生物可利用的 VHL 募集 PROTAC 在体内实现 SMARCA2 降解

Christiane Kofink #, Nicole Trainor #, Barbara Mair #, Simon Wöhrle, Melanie Wurm, Nikolai Mischerikow, Michael J Roy, Gerd Bader, Peter Greb, Géraldine Garavel, Emelyne Diers, Ross McLennan, Claire Whitworth, Vesna Vetma, Klaus Rumpel, Maximilian Scharnweber, Julian E Fuchs, Thomas Gerstberger, Yun

Framework and baseline examination of the German National Cohort (NAKO)

德国国家队列(NAKO)的框架和基线检查

Peters, Annette; Peters, Annette; Greiser, Karin Halina; Göttlicher, Susanne; Ahrens, Wolfgang; Albrecht, Maren; Bamberg, Fabian; Bärnighausen, Till; Becher, Heiko; Berger, Klaus; Beule, Achim; Boeing, Heiner; Bohn, Barbara; Bohnert, Kerstin; Braun, Bettina; Brenner, Hermann; Bülow, Robin; Castell, Stefanie; Damms-Machado, Antje; Dörr, Marcus; Ebert, Nina; Ecker, Margit; Emmel, Carina; Fischer, Beate; Franzke, Claus-Werner; Gastell, Sylvia; Giani, Guido; Günther, Matthias; Günther, Kathrin; Günther, Klaus-Peter; Haerting, Johannes; Haug, Ulrike; Heid, Iris M; Heier, Margit; Heinemeyer, Diana; Hendel, Thomas; Herbolsheimer, Florian; Hirsch, Jochen; Hoffmann, Wolfgang; Holleczek, Bernd; Hölling, Heike; Hörlein, Andreas; Jöckel, Karl-Heinz; Kaaks, Rudolf; Karch, André; Karrasch, Stefan; Kartschmit, Nadja; Kauczor, Hans-Ulrich; Keil, Thomas; Kemmling, Yvonne; Klee, Bianca; Klüppelholz, Birgit; Kluttig, Alexander; Kofink, Lisa; Köttgen, Anna; Kraft, Daniel; Krause, Gérard; Kretz, Lisa; Krist, Lilian; Kühnisch, Jan; Kuß, Oliver; Legath, Nicole; Lehnich, Anna-Therese; Leitzmann, Michael; Lieb, Wolfgang; Linseisen, Jakob; Loeffler, Markus; Macdonald, Anke; Maier-Hein, Klaus H; Mangold, Nina; Meinke-Franze, Claudia; Meisinger, Christa; Melzer, Juliane; Mergarten, Björn; Michels, Karin B; Mikolajczyk, Rafael; Moebus, Susanne; Mueller, Ulrich; Nauck, Matthias; Niendorf, Thoralf; Nikolaou, Konstantin; Obi, Nadia; Ostrzinski, Stefan; Panreck, Leo; Pigeot, Iris; Pischon, Tobias; Pschibul-Thamm, Irene; Rathmann, Wolfgang; Reineke, Achim; Roloff, Stefanie; Rujescu, Dan; Rupf, Stefan; Sander, Oliver; Schikowski, Tamara; Schipf, Sabine; Schirmacher, Peter; Schlett, Christopher L; Schmidt, Börge; Schmidt, Georg; Schmidt, Martin; Schöne, Gina; Schulz, Holger; Schulze, Matthias B; Schweig, Alexandra; Sedlmeier, Anja M; Selder, Sonja; Six-Merker, Julia; Sowade, Ramona; Stang, Andreas; Stegle, Oliver; Steindorf, Karen; Stübs, Gunthard; Swart, Enno; Teismann, Henning; Thiele, Inke; Thierry, Sigrid; Ueffing, Marius; Völzke, Henry; Waniek, Sabina; Weber, Andrea; Werner, Nicole; Wichmann, H-Erich; Willich, Stefan N; Wirkner, Kerstin; Wolf, Kathrin; Wolff, Robert; Zeeb, Hajo; Zinkhan, Melanie; Zschocke, Johannes

Preclinical Aortic Atherosclerosis in Adolescents With Chronic Disease

慢性病青少年主动脉粥样硬化的临床前期

Ververs, Francesca A; Eikendal, Anouk L M; Kofink, Daniel; Nuboer, Roos; Westenberg, Jos J M; Hovenkamp, Gijs T; Kemps, Jitske J A; Coenen, Iris C J; Daems, Joëlle J N; Claus, Laura R; Ju, Yillie; Wulffraat, Nico M; van der Ent, Cornelis K; Monaco, Claudia; Boes, Marianne; Leiner, Tim; Grotenhuis, Heynric B; Schipper, Henk S

Electrochemical Rearrangement of 3-Hydroxyoxindoles into Benzoxazinones

3-羟基吲哚酮电化学重排生成苯并噁嗪酮

Vayer, Marie; Pastor, Miryam; Kofink, Christiane; Maulide, Nuno

BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition

BI-3406 是一种强效且选择性的 SOS1-KRAS 相互作用抑制剂,可通过联合 MEK 抑制有效治疗 KRAS 驱动的癌症

Marco H Hofmann #, Michael Gmachl #, Juergen Ramharter #, Fabio Savarese, Daniel Gerlach, Joseph R Marszalek, Michael P Sanderson, Dirk Kessler, Francesca Trapani, Heribert Arnhof, Klaus Rumpel, Dana-Adriana Botesteanu, Peter Ettmayer, Thomas Gerstberger, Christiane Kofink, Tobias Wunberg, Andreas Z

Getting a Grip on the Undrugged: Targeting β-Catenin with Fragment-Based Methods

有效控制未受药物影响的疾病:利用基于片段的方法靶向β-catenin

Kessler, Dirk; Mayer, Moriz; Zahn, Stephan K; Zeeb, Markus; Wöhrle, Simon; Bergner, Andreas; Bruchhaus, Jens; Ciftci, Tuncay; Dahmann, Georg; Dettling, Maike; Döbel, Sandra; Fuchs, Julian E; Geist, Leonhard; Hela, Wolfgang; Kofink, Christiane; Kousek, Roland; Moser, Franziska; Puchner, Teresa; Rumpel, Klaus; Scharnweber, Maximilian; Werni, Patrick; Wolkerstorfer, Bernhard; Breitsprecher, Dennis; Baaske, Philipp; Pearson, Mark; McConnell, Darryl B; Böttcher, Jark

Comprehensive Lifestyle Modification Influences Medium-Term and Artificially Induced Stress in Ulcerative Colitis-A Sub-Study within a Randomized Controlled Trial Using the Trier Social Stress Test

综合生活方式干预对溃疡性结肠炎患者的中期和人为诱导应激反应有影响——一项采用特里尔社会应激测试的随机对照试验的子研究

Koch, Anna K; Schöls, Margarita; Haller, Heidemarie; Anheyer, Dennis; Cinar, Zehra; Eilert, Ronja; Kofink, Kerstin; Engler, Harald; Elsenbruch, Sigrid; Cramer, Holger; Dobos, Gustav; Langhorst, Jost

Subsequent Event Risk in Individuals With Established Coronary Heart Disease

已确诊冠心病患者的后续事件风险

Patel, Riyaz S; Tragante, Vinicius; Schmidt, Amand F; McCubrey, Raymond O; Holmes, Michael V; Howe, Laurence J; Direk, Kenan; Åkerblom, Axel; Leander, Karin; Virani, Salim S; Kaminski, Karol A; Muehlschlegel, Jochen D; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina V; Behloui, Hassan; Boeckx, Bram; Braund, Peter S; Breitling, Lutz P; Delgado, Graciela; Duarte, Nubia E; Dubé, Marie-Pierre; Dufresne, Line; Eriksson, Niclas; Foco, Luisa; Scholz, Markus; Gijsberts, Crystel M; Glinge, Charlotte; Gong, Yan; Hartiala, Jaana; Heydarpour, Mahyar; Hubacek, Jaroslav A; Kleber, Marcus; Kofink, Daniel; Kotti, Salma; Kuukasjärvi, Pekka; Lee, Vei-Vei; Leiherer, Andreas; Lenzini, Petra A; Levin, Daniel; Lyytikäinen, Leo-Pekka; Martinelli, Nicola; Mons, Ute; Nelson, Christopher P; Nikus, Kjell; Pilbrow, Anna P; Ploski, Rafal; Sun, Yan V; Tanck, Michael W T; Tang, W H Wilson; Trompet, Stella; van der Laan, Sander W; Van Setten, Jessica; Vilmundarson, Ragnar O; Viviani Anselmi, Chiara; Vlachopoulou, Efthymia; Al Ali, Lawien; Boerwinkle, Eric; Briguori, Carlo; Carlquist, John F; Carruthers, Kathryn F; Casu, Gavino; Deanfield, John; Deloukas, Panos; Dudbridge, Frank; Engstrøm, Thomas; Fitzpatrick, Natalie; Fox, Kim; Gigante, Bruna; James, Stefan; Lokki, Marja-Liisa; Lotufo, Paulo A; Marziliano, Nicola; Mordi, Ify R; Muhlestein, Joseph B; Newton-Cheh, Christopher; Pitha, Jan; Saely, Christoph H; Samman-Tahhan, Ayman; Sandesara, Pratik B; Teren, Andrej; Timmis, Adam; Van de Werf, Frans; Wauters, Els; Wilde, Arthur A M; Ford, Ian; Stott, David J; Algra, Ale; Andreassi, Maria G; Ardissino, Diego; Arsenault, Benoit J; Ballantyne, Christie M; Bergmeijer, Thomas O; Bezzina, Connie R; Body, Simon C; Boersma, Eric H; Bogaty, Peter; Bots, Michiel L; Brenner, Hermann; Brugts, Jasper J; Burkhardt, Ralph; Carpeggiani, Clara; Condorelli, Gianluigi; Cooper-DeHoff, Rhonda M; Cresci, Sharon; Danchin, Nicolas; de Faire, Ulf; Doughty, Robert N; Drexel, Heinz; Engert, James C; Fox, Keith A A; Girelli, Domenico; Grobbee, Diederick E; Hagström, Emil; Hazen, Stanley L; Held, Claes; Hemingway, Harry; Hoefer, Imo E; Hovingh, G Kees; Jabbari, Reza; Johnson, Julie A; Jukema, J Wouter; Kaczor, Marcin P; Kähönen, Mika; Kettner, Jiri; Kiliszek, Marek; Klungel, Olaf H; Lagerqvist, Bo; Lambrechts, Diether; Laurikka, Jari O; Lehtimäki, Terho; Lindholm, Daniel; Mahmoodi, B K; Maitland-van der Zee, Anke H; McPherson, Ruth; Melander, Olle; Metspalu, Andres; Niemcunowicz-Janica, Anna; Olivieri, Oliviero; Opolski, Grzegorz; Palmer, Colin N; Pasterkamp, Gerard; Pepine, Carl J; Pereira, Alexandre C; Pilote, Louise; Quyyumi, Arshed A; Richards, A Mark; Sanak, Marek; Siegbahn, Agneta; Simon, Tabassome; Sinisalo, Juha; Smith, J Gustav; Spertus, John A; Stender, Steen; Stewart, Alexandre F R; Szczeklik, Wojciech; Szpakowicz, Anna; Tardif, Jean-Claude; Ten Berg, Jurriën M; Tfelt-Hansen, Jacob; Thanassoulis, George; Thiery, Joachim; Torp-Pedersen, Christian; van der Graaf, Yolanda; Visseren, Frank L J; Waltenberger, Johannes; Weeke, Peter E; Van der Harst, Pim; Lang, Chim C; Sattar, Naveed; Cameron, Vicky A; Anderson, Jeffrey L; Brophy, James M; Pare, Guillaume; Horne, Benjamin D; März, Winfried; Wallentin, Lars; Samani, Nilesh J; Hingorani, Aroon D; Asselbergs, Folkert W