Off-target autophagy disruption associated with a novel liver toxicity in dogs for a highly basic heterobifunctional protein degrader.
一种高度碱性的异双功能蛋白降解剂引起犬类肝脏毒性,并伴有脱靶自噬破坏。
期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2025.1664889
Kath James E, Kohnken Rebecca, Brayman Timothy, Yang Junhai, Haag Katharina, Gong Jingyi, Untucht Christopher, Imhof Christiane, Robinson Kenneth P, McClure Ryan A, Sawicki James W, Buzenski Alexander, Ciurlionis Rita, Habibullah Asra, Liu Bo, Pohl Christian, Jia Zhaozhong, Scholz Spencer O, Loberg Lise I, Rivkin Alexey