日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Synthesis and Evaluation of Radiogallium-Labeled Peptide Probes for In Vivo Imaging of Legumain Activity

合成和评价放射性镓标记肽探针用于体内成像半胱氨酸蛋白酶活性

Fuchigami, Takeshi; Itagaki, Kohnosuke; Yoshida, Sakura; Nakayama, Morio; Munekane, Masayuki; Ogawa, Kazuma

Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction

避免光毒性是治疗由EYS功能障碍引起的视网膜营养不良的一种潜在治疗方法。

Otsuka, Yuki; Imamura, Keiko; Oishi, Akio; Asakawa, Kazuhide; Kondo, Takayuki; Nakai, Risako; Suga, Mika; Inoue, Ikuyo; Sagara, Yukako; Tsukita, Kayoko; Teranaka, Kaori; Nishimura, Yu; Watanabe, Akira; Umeyama, Kazuhiro; Okushima, Nanako; Mitani, Kohnosuke; Nagashima, Hiroshi; Kawakami, Koichi; Muguruma, Keiko; Tsujikawa, Akitaka; Inoue, Haruhisa

Evaluation of the Safety, Tolerability, and Pharmacokinetic Profiles of TP0473292 (TS-161), A Prodrug of a Novel Orthosteric mGlu2/3 Receptor Antagonist TP0178894, in Healthy Subjects and Its Antidepressant-Like Effects in Rodents

TP0473292 (TS-161)(一种新型正位mGlu2/3受体拮抗剂TP0178894的前药)在健康受试者中的安全性、耐受性和药代动力学特征评价及其在啮齿动物中的抗抑郁样作用

Watanabe, Mai; Marcy, Brian; Hiroki, Ayano; Watase, Hirotaka; Kinoshita, Kohnosuke; Iijima, Michihiko; Marumo, Toshiyuki; Zarate, Carlos A; Chaki, Shigeyuki

Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan

日本利用现有基因组编辑技术开发的基因治疗产品概况

Yamaguchi, Teruhide; Uchida, Eriko; Okada, Takashi; Ozawa, Keiya; Onodera, Masafumi; Kume, Akihiro; Shimada, Takashi; Takahashi, Satoru; Tani, Kenzaburo; Nasu, Yasutomo; Mashimo, Tomoji; Mizuguchi, Hiroyuki; Mitani, Kohnosuke; Maki, Kazushige

Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation

基于辅助依赖性腺病毒载体的阶段特异性荧光报告系统的双重用途,用于可视化成骨分化

Takefumi Sone, Masashi Shin, Takehito Ouchi, Hiroki Sasanuma, Arei Miyamoto, Satoshi Ohte, Sho Tsukamoto, Mahito Nakanishi, Hideyuki Okano, Takenobu Katagiri, Kohnosuke Mitani1

Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia

MGS0274 苯磺酸盐(一种强效 II 型代谢型谷氨酸受体激动剂 MGS0008 的前药,用于治疗精神分裂症)的临床前处置

Kinoshita, Kohnosuke; Ochi, Motoki; Iwata, Katsuya; Fukasawa, Misako; Yamaguchi, Jun-Ichi

Simple Derivation of Spinal Motor Neurons from ESCs/iPSCs Using Sendai Virus Vectors

利用仙台病毒载体从胚胎干细胞/诱导多能干细胞中简便地诱导脊髓运动神经元

Goto, Kazuya; Imamura, Keiko; Komatsu, Kenichi; Mitani, Kohnosuke; Aiba, Kazuhiro; Nakatsuji, Norio; Inoue, Makoto; Kawata, Akihiro; Yamashita, Hirofumi; Takahashi, Ryosuke; Inoue, Haruhisa

An inhibitor of fibroblast growth factor receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors

成纤维细胞生长因子受体 1 (FGFR1) 抑制剂促进 NGN3+ 胰腺内分泌祖细胞的晚期终末分化

Yzumi Yamashita-Sugahara, Masahito Matsumoto, Manami Ohtaka, Ken Nishimura, Mahito Nakanishi, Kohnosuke Mitani, Yasushi Okazaki

The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa

利用诱导多能干细胞揭示致病基因突变并探索视网膜色素变性的治疗方法

Yoshida, Tetsu; Ozawa, Yoko; Suzuki, Keiichiro; Yuki, Kenya; Ohyama, Manabu; Akamatsu, Wado; Matsuzaki, Yumi; Shimmura, Shigeto; Mitani, Kohnosuke; Tsubota, Kazuo; Okano, Hideyuki

Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors

使用辅助依赖性腺病毒载体在 hESC 和 hiPSC 中实现高效、准确的同源重组

Emi Aizawa, Yuka Hirabayashi, Yuzuru Iwanaga, Keiichiro Suzuki, Kenji Sakurai, Miho Shimoji, Kazuhiro Aiba, Tamaki Wada, Norie Tooi, Eihachiro Kawase, Hirofumi Suemori, Norio Nakatsuji, Kohnosuke Mitani