日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Elucidation of Mechanism of Action in Drug Invention: Using Stable Isotope Tracers to Unravel Biochemical Kinetics

药物研发中作用机制的阐明:利用稳定同位素示踪剂揭示生化动力学

Kohnz, Rebecca A; Zhou, Dan; Lou, Bin; Yao, Huifang; McKenney, David; Dokwal, Dhiraj; Villanueva, Ruth; Kocalis, Heidi; Ballard, Jeanine E; Piesvaux, Jennifer; Previs, Stephen F

Oncogene-regulated release of extracellular vesicles

致癌基因调节细胞外囊泡的释放

Seda Kilinc, Rebekka Paisner, Roman Camarda, Suprit Gupta, Olga Momcilovic, Rebecca A Kohnz, Baris Avsaroglu, Noelle D L'Etoile, Rushika M Perera, Daniel K Nomura, Andrei Goga

MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer

MYC 驱动的谷氨酸-半胱氨酸连接酶抑制促进肝癌中的谷胱甘肽耗竭

Brittany Anderton, Roman Camarda, Sanjeev Balakrishnan, Asha Balakrishnan, Rebecca A Kohnz, Lionel Lim, Kimberley J Evason, Olga Momcilovic, Klaus Kruttwig, Qiang Huang, Guowang Xu, Daniel K Nomura, Andrei Goga

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

抑制脂肪酸氧化作为 MYC 过度表达三阴性乳腺癌的治疗方法

Roman Camarda, Alicia Y Zhou, Rebecca A Kohnz, Sanjeev Balakrishnan, Celine Mahieu, Brittany Anderton, Henok Eyob, Shingo Kajimura, Aaron Tward, Gregor Krings, Daniel K Nomura, Andrei Goga

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

脂质生物合成协调线粒体至细胞质的应激反应

Hyun-Eui Kim, Ana Rodrigues Grant, Milos S Simic, Rebecca A Kohnz, Daniel K Nomura, Jenni Durieux, Celine E Riera, Melissa Sanchez, Erik Kapernick, Suzanne Wolff, Andrew Dillin

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

线粒体 DNA 复制缺陷会干扰细胞 dNTP 池并重塑一碳代谢

Joni Nikkanen, Saara Forsström, Liliya Euro, Ilse Paetau, Rebecca A Kohnz, Liya Wang, Dmitri Chilov, Jenni Viinamäki, Anne Roivainen, Päivi Marjamäki, Heidi Liljenbäck, Sofia Ahola, Jana Buzkova, Mügen Terzioglu, Nahid A Khan, Sini Pirnes-Karhu, Anders Paetau, Tuula Lönnqvist, Antti Sajantila, Pirjo

Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity

蛋白质唾液酸化调控基因表达特征,从而促进乳腺癌细胞致病性

Rebecca A Kohnz ,Lindsay S Roberts ,David DeTomaso ,Lara Bideyan ,Peter Yan ,Sourav Bandyopadhyay ,Andrei Goga ,Nir Yosef ,Daniel K Nomura

Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer

基于活性的蛋白质谱分析揭示了癌基因驱动的代谢变化中PAFAH1B2和1B3在癌症中的广泛失调。

Kohnz, Rebecca A; Mulvihill, Melinda M; Chang, Jae Won; Hsu, Ku-Lung; Sorrentino, Antonio; Cravatt, Benjamin F; Bandyopadhyay, Sourav; Goga, Andrei; Nomura, Daniel K

Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids

以化学方法治疗性地靶向内源性大麻素 2-AG 和二十碳酸类物质的代谢和信号传导

Kohnz, Rebecca A; Nomura, Daniel K

Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness

肌醇磷酸酯的再循环调节糖酵解和脂质代谢,从而驱动癌症的侵袭性。

Benjamin, Daniel I; Louie, Sharon M; Mulvihill, Melinda M; Kohnz, Rebecca A; Li, Daniel S; Chan, Lauryn G; Sorrentino, Antonio; Bandyopadhyay, Sourav; Cozzo, Alyssa; Ohiri, Anayo; Goga, Andrei; Ng, Shu-Wing; Nomura, Daniel K