日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

In vivo site-specific engineering to reprogram T cells

利用体内位点特异性工程技术重编程T细胞

Nyberg, William A; Bernard, Pierre-Louis; Ngo, Wayne; Wang, Charlotte H; Ark, Jonathan; Rothrock, Allison; Borgo, Gina M; Kimmerly, Gabriella R; Jung, Jae Hyung; Allain, Vincent; Hamilton, Jennifer R; Baldwin, Alisha; Stickels, Robert; Wyman, Sarah; Khan, Safwaan H; Lang, Shanshan; Marsh, Donna; Almudhfar, Niran; Novick, Catherine; Mortazavi, Yasaman; Zhang, Shimin; AbdElwakil, Mahmoud M; Sandoval, Luis R; Hwang, Sidney; Chu, Simon N; Jung, Hyuncheol; Liu, Chang; Sharma, Devesh; McCreary, Travis; Li, Zhongmei; Satpathy, Ansuman T; Carnevale, Julia; Rutishauser, Rachel L; Cromer, M Kyle; Roybal, Kole T; Dodgson, Stacie E; Doudna, Jennifer A; Asokan, Aravind; Eyquem, Justin

Engineered receptors for soluble cellular communication and disease sensing

用于可溶性细胞通讯和疾病感知的工程受体

Dan I Piraner #, Mohamad H Abedi #, Maria J Duran Gonzalez #, Adam Chazin-Gray #, Annie Lin, Iowis Zhu, Pavithran T Ravindran, Thomas Schlichthaerle, Buwei Huang, Tyler H Bearchild, David Lee, Sarah Wyman, Young-Wook Jun, David Baker, Kole T Roybal6

Naturally occurring T cell mutations enhance engineered T cell therapies

自然发生的T细胞突变可增强工程化T细胞疗法的效果。

Julie Garcia #,Jay Daniels #,Yujin Lee,Iowis Zhu,Kathleen Cheng,Qing Liu,Daniel Goodman,Cassandra Burnett,Calvin Law,Chloë Thienpont,Josef Alavi,Camillia Azimi,Garrett Montgomery,Kole T Roybal,Jaehyuk Choi

CD4+ CAR T-cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR T-cell therapy

CD4+ CAR T 细胞衰竭与 BCMA CAR T 细胞治疗后多发性骨髓瘤早期复发相关

Guy Ledergor, Zenghua Fan, Kai Wu, Elizabeth McCarthy, Axel Hyrenius-Wittsten, Alec Starzinski, Hewitt Chang, Mark Bridge, Serena Kwek, Alexander Cheung, Sophia Bylsma, Erik Hansen, Jeffrey Wolf, Sandy Wong, Nina Shah, Kole T Roybal, Thomas Martin, Chun J Ye, Lawrence Fong

Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma

用于乳腺癌和胶质母细胞瘤 PET 成像的抗原依赖性诱导 T 细胞报告系统

Jaehoon Shin, Matthew F L Parker, Iowis Zhu, Aryn Alanizi, Carlos I Rodriguez, Raymond Liu, Payal B Watchmaker, Mausam Kalita, Joseph Blecha, Justin Luu, Brian Wright, Suzanne E Lapi, Robert R Flavell, Hideho Okada, Thea D Tlsty, Kole T Roybal, David M Wilson

Synthesizing a Smarter CAR T Cell: Advanced Engineering of T-cell Immunotherapies

合成更智能的CAR-T细胞:T细胞免疫疗法的先进工程技术

Zhu, Iowis; Piraner, Dan I; Roybal, Kole T

Hyperstabilization of T cell microvilli contacts by chimeric antigen receptors

嵌合抗原受体对T细胞微绒毛接触的过度稳定作用

Casey Beppler ,John Eichorst ,Kyle Marchuk ,En Cai ,Carlos A Castellanos ,Venkataraman Sriram ,Kole T Roybal # ,Matthew F Krummel #

Synthetic cytokine circuits that drive T cells into immune-excluded tumors

诱导T细胞进入免疫排斥肿瘤的合成细胞因子回路

Allen, Greg M; Frankel, Nicholas W; Reddy, Nishith R; Bhargava, Hersh K; Yoshida, Maia A; Stark, Sierra R; Purl, Megan; Lee, Jungmin; Yee, Jacqueline L; Yu, Wei; Li, Aileen W; Garcia, K Christopher; El-Samad, Hana; Roybal, Kole T; Spitzer, Matthew H; Lim, Wendell A

Multidimensional control of therapeutic human cell function with synthetic gene circuits

利用合成基因回路对治疗性人类细胞功能进行多维度控制

Li, Hui-Shan; Israni, Divya V; Gagnon, Keith A; Gan, Kok Ann; Raymond, Michael H; Sander, Jeffry D; Roybal, Kole T; Joung, J Keith; Wong, Wilson W; Khalil, Ahmad S

Modular design of synthetic receptors for programmed gene regulation in cell therapies

细胞疗法中用于程序化基因调控的合成受体的模块化设计

Iowis Zhu,Raymond Liu,Julie M Garcia,Axel Hyrenius-Wittsten,Dan I Piraner,Josef Alavi,Divya V Israni,Bin Liu,Ahmad S Khalil,Kole T Roybal