日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Improved targeted delivery of antisense oligonucleotide with an antibody mask

利用抗体掩蔽技术改进反义寡核苷酸的靶向递送

Hsia, Hung-En; Zanini, Chiara; Simonneau, Claire; Fraidling, Johannes; Kraft, Thomas E; Mayer, Klaus; Sommer, Annika; Indlekofer, Annette; Wirth, Tamara; Benz, Jörg; Georges, Guy; Langer, Lukas M; Gassner, Christian; Larraillet, Vincent; Lohmann, Sabine; Koller, Erich; Mansø, Mads; Ravn, Jacob; Hofer, Kerstin; Emrich, Thomas; Niewöhner, Jens; Schumacher, Felix; Brinkmann, Ulrich

Angelman syndrome patient-derived neuron screen leads to clinical ASO rugonersen targeting UBE3A-ATS with long-lasting effect in monkeys.

安格曼综合征患者来源的神经元筛选产生了临床 ASO rugonersen,该药物靶向 UBE3A-ATS,在猴子身上具有持久疗效

Jagasia Ravi, Bon Charlotte, Rasmussen Soren V, Badillo Solveig, Tehler Disa, Buchy Danièle, Berrera Marco, Prasad Megana, Chamberlain Stormy, Terrigno Marco, Pandya Nikhil J, Costa Veronica, Wang Congwei, Pedersen Lykke, Miller Meghan T, Erichsen Kamille Dumong, Joenson Lars, Patsch Christoph, Hipp Joerg F, Bonni Azad, Müller Lutz, Braendli-Baiocco Annamaria, Kremer Thomas, Koller Erich, Hoener Marius C

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages

含有非手性3'和5'硫代磷酸酯键的治疗性寡核苷酸的体外和体内特性

Duschmalé, Jörg; Hansen, Henrik Frydenlund; Duschmalé, Martina; Koller, Erich; Albaek, Nanna; Møller, Marianne Ravn; Jensen, Klaus; Koch, Troels; Wengel, Jesper; Bleicher, Konrad

TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry

三环DNA修饰的寡聚-2'-脱氧核苷酸可降低肝脏和肝外组织中清道夫受体B1 mRNA的表达——寡核苷酸长度、设计和化学性质的比较研究

Murray, Sue; Ittig, Damian; Koller, Erich; Berdeja, Andres; Chappell, Alfred; Prakash, Thazha P; Norrbom, Michaela; Swayze, Eric E; Leumann, Christian J; Seth, Punit P

Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML

ARC(具有caspase募集结构域的凋亡抑制因子)是一种抗凋亡蛋白,其表达在急性髓系白血病(AML)中具有很强的预后价值。

Carter, Bing Z; Qiu, Yi Hua; Zhang, Nianxiang; Coombes, Kevin R; Mak, Duncan H; Thomas, Deborah A; Ravandi, Farhad; Kantarjian, Hagop M; Koller, Erich; Andreeff, Michael; Kornblau, Steven M

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

单链硫代磷酸酯修饰的反义寡核苷酸在肝细胞中积累的机制

Koller, Erich; Vincent, Thomas M; Chappell, Alfred; De, Soma; Manoharan, Muthiah; Bennett, C Frank

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML

p53 的同时激活和 XIAP 的抑制增强了急性髓系白血病 (AML) 中细胞凋亡信号通路的激活。

Carter, Bing Z; Mak, Duncan H; Schober, Wendy D; Koller, Erich; Pinilla, Clemencia; Vassilev, Lyubomir T; Reed, John C; Andreeff, Michael