日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The E3-ome gene-centric compendium reveals the human E3 ligase landscape.

以 E3 连接酶组为中心的基因汇编揭示了人类 E3 连接酶的全貌。

Chua Ngee Kiat, González-Robles Tania J, Reddington Cameron J, Dudley-Fraser Jane, Birkinshaw Richard W, Han Jiru, Solano Ashleigh, Wong Soon Wei, Kochańczyk Tomasz, Peter Joshua J, Nakasone Mark A, Aust Florian, Munro Jacob, Tong Yeh Huei, Iskander Julie, Abeysekera Waruni, Garnham Alex, Huckstep Hannah, Ritchie Matthew E, Wertz Ingrid, Hymowitz Sarah, Kumar Sharad, Conaway Ron C, Privé Gilbert G, Bullock Alex N, Babon Jeffrey J, Klevit Rachel E, Lorenz Sonja, Ciulli Alessio, Fischer Eric S, Thomä Nicolas H, Nowak Radosław P, Schulman Brenda A, Rapé Michael, Rittinger Katrin, Pagan Julia K, Bahlo Melanie, Mackay Joel P, Mace Peter D, Lima Christopher D, Hay Ronald T, Komander David, Lechtenberg Bernhard C, Joazeiro Claudio A P, Pagano Michele, Hofmann Kay, Feltham Rebecca

GID/CTLH E3 ligase complex control cell fate programs for sexual development of Plasmodium falciparum

GID/CTLH E3连接酶复合物控制恶性疟原虫有性发育的细胞命运程序

Marapana, Danushka S; Lopaticki, Sash; Balan, Balu; Reaksudsan, Kitsanapong; Cobbold, Simon A; Geoghegan, Niall D; Khurana, Sachin; Scally, Stephen W; Hickey, Peter; Jayakrishnan, Niva; Vaibhav, Vineet; Spall, Sukhdeep; Yousef, Jumana M; Dagley, Laura F; Goodman, Christopher D; Cozijnsen, Anton; McFadden, Geoffrey I; Rogers, Kelly L; Jex, Aaron; Komander, David; McCarthy, James S; Tonkin, Christopher J; Dixon, Matthew W A; Cowman, Alan F

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.

一种新型PLpro抑制剂改善了新冠肺炎长期症状的临床前模型的结果

M Bader Stefanie, Calleja Dale J, Devine Shane M, Kuchel Nathan W, Lu Bernadine G C, Wu Xinyu, Birkinshaw Richard W, Bhandari Reet, Loi Katie, Volpe Rohan, Khakham Yelena, Au Amanda E, Blackmore Timothy R, Mackiewicz Liana, Dayton Merle, Schaefer Jan, Scherer Lena, Stock Angus T, Cooney James P, Schoffer Kael, Maluenda Ana, Kleeman Elizabeth A, Davidson Kathryn C, Allison Cody C, Ebert Gregor, Chen Gong, Katneni Kasiram, Klemm Theresa A, Nachbur Ueli, Georgy Smitha Rose, Czabotar Peter E, Hannan Anthony J, Putoczki Tracy L, Tanzer Maria, Pellegrini Marc, Lechtenberg Bernhard C, Charman Susan A, Call Melissa J, Mitchell Jeffrey P, Lowes Kym N, Lessene Guillaume, Doerflinger Marcel, Komander David

USP10/GSK3β-mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer

USP10/GSK3β介导的PTEN抑制导致乳腺癌对PI3K抑制剂产生耐药性

Kumari, Nishi; Wright, Sarah Ce; Witham, Christopher M; Monserrat, Laia; Palafox, Marta; Richard, John Lc; Costa, Carlotta; Elkabets, Moshe; Agostino, Mark; Klemm, Theresa; Eccles, Melissa; Garnham, Alex; Wu, Ting; Nilsson, Jonas A; Walz, Nikita; Venugopal, Veena; Cerra, Anthony; Vasilevski, Natali; Bridgeman, Stephanie; Bassi, Sona; Saei, Azad; Helal, Moutaz; Neundorf, Philipp; Riedel, Angela; Rosenfeldt, Mathias; Gill, Jespal; Pahor, Nikolett; Hartmann, Oliver; Chung, Jacky; Sidhu, Sachdev S; Moderau, Nina; Jha, Sudhakar; Rodon, Jordi; Diefenbacher, Markus E; Komander, David; Serra, Violeta; Eichhorn, Pieter Johan Adam

Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain

小鼠抗原呈递细胞中的主要组织相容性复合体II类分子被分支的K63和K11连接的泛素链修饰。

Liu, Haiyin; Francis, Lauren; Dagley, Laura F; Cobbold, Simon A; Webb, Andrew I; Komander, David; Villadangos, Jose A; Mintern, Justine D

Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes.

对两种恶性疟原虫 Cullin-RING-连接酶复合物的组分进行功能表征

Marapana Danushka, Cobbold Simon A, Pasternak Michal, Shami Gerald J, Ralph Stuart A, Lopaticki Sash, Yousef Jumana, Vaibhav Vineet, Dagley Laura F, Komander David, Cowman Alan F

Differentiation of Toxoplasma into latent forms is linked to central carbon metabolism and requires a GID/CTLH-type E3 ubiquitin ligase

弓形虫分化为潜伏型与中心碳代谢有关,并且需要GID/CTLH型E3泛素连接酶。

Uboldi, Alessandro D; Khurana, Sachin; Jaywickrama, Amalie A; Lekkala-Lethakula, Sai Prasanna; Simonpietri, Amber; Singh, Karan; Hofferek, Vinzenz; Ruparel, Ushma; Whitehead, Lachlan L; Rogers, Kelly L; Garnham, Alexandra L; Scott, Nichollas; Katris, Nicholas J; McConville, Malcolm J; Komander, David; Cobbold, Simon A; Tonkin, Christopher J

Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape

SARS-CoV-2 木瓜蛋白酶样蛋白酶的突变分析揭示了其功能、结构和药物逃逸的要求

Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Kathleen Zeglinski, Kym N Lowes, Dale J Calleja, Jeffrey P Mitchell, Guillaume Lessene, David Komander, Matthew E Call, Melissa J Call

Interaction of PINK1 with nucleotides and kinetin

PINK1与核苷酸和激动素的相互作用

Zhong Yan Gan,Sylvie Callegari,Thanh N Nguyen,Nicholas S Kirk,Andrew Leis,Michael Lazarou,Grant Dewson,David Komander

Secondary interactions in ubiquitin-binding domains achieve linkage or substrate specificity

泛素结合域中的二级相互作用实现连接或底物特异性

Martin A Michel, Simon Scutts, David Komander