日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of a novel potent tubulin inhibitor through virtual screening and target validation for cancer chemotherapy.

通过虚拟筛选和靶点验证,发现了一种新型强效微管蛋白抑制剂,用于癌症化疗

Shan Peipei, Liu Kai-Lu, Jiang Xiu, Zhou Guangzhao, Zhu Kongkai, Zhang Hua

First total synthesis, antitumor evaluation and target identification of mornaphthoate E: A new tubulin inhibitor template acting on PI3K/Akt signaling pathway

作用于PI3K/Akt信号通路的新型微管蛋白抑制剂模板萘甲酸酯E的首次全合成、抗肿瘤评价及靶标鉴定

Peipei Shan, Tao Ye, Ying-De Tang, Hui Song, Chao Wang, Kongkai Zhu, Feifei Yang, Shi-Lei Zhang, Pei-Wen Su, Shuanhu Gao, Hua Zhang

Ligand recognition and G protein coupling of the human itch receptor MRGPRX1

人类瘙痒受体 MRGPRX1 的配体识别和 G 蛋白偶联

Lulu Guo #, Yumu Zhang #, Guoxing Fang #, Lu Tie #, Yuming Zhuang #, Chenyang Xue #, Qi Liu #, Minghui Zhang, Kongkai Zhu, Chongzhao You, Peiyu Xu, Qingning Yuan, Chao Zhang, Lei Liu, Naikang Rong, Shengxuan Peng, Yuan Liu, Chuanzheng Wang, Xin Luo, Zongyao Lv, Dongwei Kang, Xiao Yu, Cheng Zhang, Yi

PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1

PRMT5通过甲基化ENO1增强Warburg效应,从而促进卵巢癌的生长。

Xie, Fei; Zhang, Han; Zhu, Kongkai; Jiang, Cheng-Shi; Zhang, Xiaoya; Chang, Hongkai; Qiao, Yaya; Sun, Mingming; Wang, Jiyan; Wang, Mukuo; Tan, Junzhen; Wang, Tao; Zhao, Lianmei; Zhang, Yuan; Lin, Jianping; Zhang, Chunze; Liu, Shuangping; Zhao, Jianguo; Luo, Cheng; Zhang, Shuai; Shan, Changliang

Cell membrane-targeting NIR fluorescent probes with large Stokes shifts for ultralong-term transplanted neural stem cell tracking

用于超长期追踪移植神经干细胞的具有大斯托克斯位移的细胞膜靶向近红外荧光探针

Chen, Jing; Li, Dan; Li, Hongfu; Zhu, Kongkai; Shi, Leilei; Fu, Xuemei

Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis

靶向血小板中 Src SH3 的 RT 环可在不影响止血的情况下预防血栓形成

Jianhua Mao, Kongkai Zhu, Zhangbiao Long, Huimin Zhang, Bing Xiao, Wenda Xi, Yun Wang, Jiansong Huang, Jingqiu Liu, Xiaofeng Shi, Hao Jiang, Tian Lu, Yi Wen, Naixia Zhang, Qian Meng, Hu Zhou, Zheng Ruan, Jin Wang, Cheng Luo, Xiaodong Xi

Discovery of New α-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation

新型 α-葡萄糖苷酶抑制剂的发现:基于结构的虚拟筛选和生物学评价

Shan-Kui Liu, Haifang Hao, Yuan Bian, Yong-Xi Ge, Shengyuan Lu, Hong-Xu Xie, Kai-Ming Wang, Hongrui Tao, Chao Yuan, Juan Zhang, Jie Zhang, Cheng-Shi Jiang, Kongkai Zhu

Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α

靶向PRMT5活性通过促进HNF4α转录抑制肝细胞癌的恶性程度

Bai-Nan Zheng, Chen-Hong Ding, Shi-Jie Chen, Kongkai Zhu, Jingwei Shao, Jifeng Feng, Wen-Ping Xu, Ling-Yan Cai, Chang-Peng Zhu, Wenhu Duan, Jin Ding, Xin Zhang, Cheng Luo, Wei-Fen Xie

Arsenic circumvents the gefitinib resistance by binding to P62 and mediating autophagic degradation of EGFR in non-small cell lung cancer

砷通过与 P62 结合并介导非小细胞肺癌中 EGFR 的自噬降解来绕过吉非替尼耐药性

Jianhua Mao, Lie Ma, Yan Shen, Kongkai Zhu, Ru Zhang, Wenda Xi, Zheng Ruan, Cheng Luo, Zhu Chen, Xiaodong Xi, Saijuan Chen

Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy

鉴定一种新型小分子 Keap1-Nrf2 PPI 抑制剂,对 LPS 诱发的心肌病具有细胞保护作用

Cheng-Shi Jiang, Chun-Lin Zhuang, Kongkai Zhu, Juan Zhang, Luis Alexandre Muehlmann, João Paulo Figueiró Longo, Ricardo Bentes Azevedo, Wen Zhang, Ning Meng, Hua Zhang