日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Reducing hERG Inhibition in the Design of Potent and Bioavailable Indazole cGAS Inhibitors

在设计高效且生物利用度高的吲唑类cGAS抑制剂时降低hERG抑制

Cyr, Patrick; Chefson, Amandine; Sietsema, Daniel V; Konteatis, Zenon; Ciblat, Stéphane; Sgarioto, Nicolas; Le Gros, Philippe; Pike, Kelly A; Boily, Marc-Olivier; Diallo, Mohamed; Seliniotakis, Ria; Springer, Clayton; Khandelwal, Pradhyum; Beveridge, Ramsay E

MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage

MAT2A 抑制通过减少 PRMT5 依赖性 mRNA 剪接和诱导 DNA 损伤来阻止 MTAP 删除的癌细胞的生长

Peter Kalev, Marc L Hyer, Stefan Gross, Zenon Konteatis, Chi-Chao Chen, Mark Fletcher, Max Lein, Elia Aguado-Fraile, Victoria Frank, Amelia Barnett, Everton Mandley, Joshua Goldford, Yue Chen, Katie Sellers, Sebastian Hayes, Kate Lizotte, Phong Quang, Yesim Tuncay, Michelle Clasquin, Rachel Peters, 

Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML

IDH1突变复发或难治性AML患者接受ivosidenib单药治疗后复发的分子机制

Choe, Sung; Wang, Hongfang; DiNardo, Courtney D; Stein, Eytan M; de Botton, Stéphane; Roboz, Gail J; Altman, Jessica K; Mims, Alice S; Watts, Justin M; Pollyea, Daniel A; Fathi, Amir T; Tallman, Martin S; Kantarjian, Hagop M; Stone, Richard M; Quek, Lynn; Konteatis, Zenon; Dang, Lenny; Nicolay, Brandon; Nejad, Parham; Liu, Guowen; Zhang, Vickie; Liu, Hua; Goldwasser, Meredith; Liu, Wei; Marks, Kevin; Bowden, Chris; Biller, Scott A; Attar, Eyal C; Wu, Bin

Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma

Vorasidenib (AG-881):一种首创的、可穿透血脑屏障的突变型IDH1和IDH2双重抑制剂,用于治疗胶质瘤

Konteatis, Zenon; Artin, Erin; Nicolay, Brandon; Straley, Kimberly; Padyana, Anil K; Jin, Lei; Chen, Yue; Narayaraswamy, Rohini; Tong, Shuilong; Wang, Feng; Zhou, Ding; Cui, Dawei; Cai, Zhenwei; Luo, Zhiyong; Fang, Cheng; Tang, Huachun; Lv, Xiaobing; Nagaraja, Raj; Yang, Hua; Su, Shin-San M; Sui, Zhihua; Dang, Lenny; Yen, Katharine; Popovici-Muller, Janeta; Codega, Paolo; Campos, Carl; Mellinghoff, Ingo K; Biller, Scott A

Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors

C5a与其受体的双位点结合:G蛋白偶联受体的另一种结合模式

Siciliano, S J; Rollins, T E; DeMartino, J; Konteatis, Z; Malkowitz, L; Van Riper, G; Bondy, S; Rosen, H; Springer, M S