Konvalinka Jan相关文献与解析，生知库 | 链接生命科学的每一步

Potent Competitive Inhibitors of Ecto-5'-nucleotidase (CD73) based on 6‑(Het)aryl-7-deazapurine Ribonucleoside 5'‑O‑Bisphosphonates

基于 6-(杂)芳基-7-脱氮嘌呤核糖核苷 5'-O-双膦酸盐的强效 Ecto-5'-核苷酸酶 (CD73) 竞争性抑制剂

期刊:ACS Pharmacology and Translational Science

Šinkevičiu̅tė, Ugnė; Šímová, Magdalena; Staník, Radek; Poštová Slavětínská, Lenka; Blažková, Kristýna; Šácha, Pavel; Lepšík, Martin; Řezáč, Jan; Konvalinka, Jan; Ormsby, Tereza; Tichý, Michal; Hocek, Michal

On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents.

新型隐球菌 May1 大环抑制剂的树脂上组装：通往强效抗真菌剂的途径

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c00396

KryÅ¡tÅ¯fek Robin, Verner VÃ¡clav, Å Ã¡cha Pavel, Hadzima Martin, Trajhan Filip, StarkovÃ¡ Jana, TlouÅ¡t'ovÃ¡ Eva, DvoÅÃ¡kovÃ¡ Alexandra, Pecina Adam, Brynda JiÅÃ, ChalupskÃ½ Karel, HÃ¡jek Miroslav, Boucher Michael J, Majer Pavel, ÅezÃ¡Ä Jan, Madhani Hiten D, Craik Charles S, Konvalinka Jan

微生物学

发表日期：2025

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Uncovering the glutamate carboxypeptidase II microenvironment using a multi-labeling proteomic approach

利用多标记蛋白质组学方法揭示谷氨酸羧肽酶II的微环境

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-28826-5

Pokorná, Jana; Hadzima, Martin; Křenková, Alena; Smith, Joshua D; Šubr, Vladimír; Kryštůfek, Robin; Hubálek, Martin; Starková, Jana; Šrámková, Karolína; Etrych, Tomáš; Kostka, Libor; Sedlák, František; Konvalinka, Jan; Šácha, Pavel

发表日期：2025

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Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights

靶向裂谷热病毒聚合酶：耐药机制和结构解析

期刊:ACS Infectious Diseases

影响因子:3.8

doi:10.1021/acsinfecdis.5c00832

Král', Michal; Das, Amiyaranjan; Kotačka, Tomáš; Blahošová, Anna; Liščáková, Veronika; Hodek, Jan; Konvalinka, Jan; Demo, Gabriel; Kožíšek, Milan

微生物学

发表日期：2025

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Identification of 6âAryl-7-Deazapurine Ribonucleoside Phosphonates as Inhibitors of Ecto-5'-Nucleotidase (CD73).

鉴定 6'芳基-7-脱氮嘌呤核糖核苷膦酸酯为外-5'-核苷酸酶 (CD73) 抑制剂

期刊:ACS Pharmacology and Translational Science

影响因子:3.7

doi:10.1021/acsptsci.5c00180

Å ÃmovÃ¡ Magdalena, Ormsby Tereza, Å inkeviÄiuÌ tÄ UgnÄ, SirotovÃ¡ VeselovskÃ¡ Lucia, ÄermÃ¡kovÃ¡ KateÅina, Hadzima Martin, BartoÅ Lenka, StaÅurovÃ¡ Jana, KramnÃ¡ AneÅ¾ka, Å Ã¡cha Pavel, TichÃ½ Michal, Hocek Michal, Konvalinka Jan, Blazkova Kristyna

信号转导

发表日期：2025

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Beyond natural flavonoids: exploring bioisosterism in design and synthesis of influenza endonuclease inhibitors

超越天然类黄酮：探索生物等排性在流感核酸内切酶抑制剂设计与合成中的应用

期刊:RSC Medicinal Chemistry

影响因子:3.6

doi:10.1039/d5md00071h

Reiberger, Róbert; Kráľ, Michal; Radilová, Kateřina; Kotačka, Tomáš; Dračínský, Martin; Tsalyy, Artem; Brynda, Jiří; Majer, Pavel; Konvalinka, Jan; Kožíšek, Milan; Machara, Aleš

Prebiotically Plausible Peptides can Self-assemble into β-rich Nanostructures

具有生命起源前合理性的肽可以自组装成富含β折叠的纳米结构

期刊:

影响因子:

doi:10.1101/2025.11.09.687475

Makarov, Mikhail; Kryštůfek, Robin; Friček, Matúš; Manriquez-Sandoval, Edgar; Dutta, Soumya; Kormaník, Ján Michael; Kalvoda, Tadeáš; Verner, Václav; Bednárová, Lucie; Charnavets, Tatsiana; Lebl, Michal; Brown, Sean M; Hadravová, Romana; Konvalinka, Jan; Singharoy, Abhishek; Fried, Stephen D; Hlouchová, Klára

发表日期：2025

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Polymer-Tethered Quenched Fluorescent Probes for Enhanced Imaging of Tumor-Associated Proteases

用于增强肿瘤相关蛋白酶成像的聚合物连接淬灭荧光探针

期刊:ACS Sensors

影响因子:9.1

doi:10.1021/acssensors.4c00912

Hadzima, Martin; Faucher, Franco F; Blažková, Kristýna; Yim, Joshua J; Guerra, Matteo; Chen, Shiyu; Woods, Emily C; Park, Ki Wan; Šácha, Pavel; Šubr, Vladimír; Kostka, Libor; Etrych, Tomáš; Majer, Pavel; Konvalinka, Jan; Bogyo, Matthew

Polymer-tethered quenched fluorescent probes for enhanced imaging of tumor associated proteases

用于增强肿瘤相关蛋白酶成像的聚合物连接淬灭荧光探针

期刊:

影响因子:

doi:10.1101/2024.05.06.592849

Hadzima, Martin; Faucher, Franco; Blažková, Kristýna; Yim, Joshua J; Guerra, Matteo; Chen, Shiyu; Woods, Emily C; Park, Ki Wan; Šácha, Pavel; Šubr, Vladimír; Kostka, Libor; Etrych, Tomáš; Majer, Pavel; Konvalinka, Jan; Bogyo, Matthew

Efficient Method for High-Throughput Screening of Compound Libraries Targeting Human PD-L1

高效筛选靶向人PD-L1化合物库的方法

Potent Competitive Inhibitors of Ecto-5'-nucleotidase (CD73) based on 6‑(Het)aryl-7-deazapurine Ribonucleoside 5'‑O‑Bisphosphonates

基于 6-(杂)芳基-7-脱氮嘌呤核糖核苷 5'-O-双膦酸盐的强效 Ecto-5'-核苷酸酶 (CD73) 竞争性抑制剂

On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents.

新型隐球菌 May1 大环抑制剂的树脂上组装：通往强效抗真菌剂的途径

Uncovering the glutamate carboxypeptidase II microenvironment using a multi-labeling proteomic approach

利用多标记蛋白质组学方法揭示谷氨酸羧肽酶II的微环境

Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights

靶向裂谷热病毒聚合酶：耐药机制和结构解析

Identification of 6âAryl-7-Deazapurine Ribonucleoside Phosphonates as Inhibitors of Ecto-5'-Nucleotidase (CD73).

鉴定 6'芳基-7-脱氮嘌呤核糖核苷膦酸酯为外-5'-核苷酸酶 (CD73) 抑制剂

Beyond natural flavonoids: exploring bioisosterism in design and synthesis of influenza endonuclease inhibitors

超越天然类黄酮：探索生物等排性在流感核酸内切酶抑制剂设计与合成中的应用

Prebiotically Plausible Peptides can Self-assemble into β-rich Nanostructures

具有生命起源前合理性的肽可以自组装成富含β折叠的纳米结构

Polymer-Tethered Quenched Fluorescent Probes for Enhanced Imaging of Tumor-Associated Proteases

用于增强肿瘤相关蛋白酶成像的聚合物连接淬灭荧光探针

Polymer-tethered quenched fluorescent probes for enhanced imaging of tumor associated proteases

用于增强肿瘤相关蛋白酶成像的聚合物连接淬灭荧光探针

Efficient Method for High-Throughput Screening of Compound Libraries Targeting Human PD-L1

高效筛选靶向人PD-L1化合物库的方法

Potent Competitive Inhibitors of Ecto-5'-nucleotidase (CD73) based on 6‑(Het)aryl-7-deazapurine Ribonucleoside 5'‑O‑Bisphosphonates

基于 6-(杂)芳基-7-脱氮嘌呤核糖核苷 5'-O-双膦酸盐的强效 Ecto-5'-核苷酸酶 (CD73) 竞争性抑制剂

On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents.

新型隐球菌 May1 大环抑制剂的树脂上组装：通往强效抗真菌剂的途径

Uncovering the glutamate carboxypeptidase II microenvironment using a multi-labeling proteomic approach

利用多标记蛋白质组学方法揭示谷氨酸羧肽酶II的微环境

Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights

靶向裂谷热病毒聚合酶：耐药机制和结构解析

Identification of 6âAryl-7-Deazapurine Ribonucleoside Phosphonates as Inhibitors of Ecto-5'-Nucleotidase (CD73).

鉴定 6'芳基-7-脱氮嘌呤核糖核苷膦酸酯为外-5'-核苷酸酶 (CD73) 抑制剂

Beyond natural flavonoids: exploring bioisosterism in design and synthesis of influenza endonuclease inhibitors

超越天然类黄酮：探索生物等排性在流感核酸内切酶抑制剂设计与合成中的应用

Prebiotically Plausible Peptides can Self-assemble into β-rich Nanostructures

具有生命起源前合理性的肽可以自组装成富含β折叠的纳米结构

Polymer-Tethered Quenched Fluorescent Probes for Enhanced Imaging of Tumor-Associated Proteases

用于增强肿瘤相关蛋白酶成像的聚合物连接淬灭荧光探针

Polymer-tethered quenched fluorescent probes for enhanced imaging of tumor associated proteases

用于增强肿瘤相关蛋白酶成像的聚合物连接淬灭荧光探针

Identification of 6âAryl-7-Deazapurine Ribonucleoside Phosphonates as Inhibitors of Ecto-5'-Nucleotidase (CD73).