日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Caspase cleavage of APP contributes to amyloid beta-protein induced synaptic injury

APP的半胱天冬酶切割导致β-淀粉样蛋白诱导的突触损伤。

Midthune, Brea; Park, Goonho; Tyan, Sheue-Houy; Koo, Edward H

Localized APP expression results in progressive network dysfunction by disorganizing spike timing.

局部APP表达会扰乱脉冲时序,从而导致网络功能逐渐受损

Viana da Silva Silvia, Haberl Matthias G, Gaur Kshitij, Patel Rina, Narayan Gautam, Ledakis Max, Fu Maylin L, de Castro Vieira Miguel, Koo Edward H, Leutgeb Jill K, Leutgeb Stefan

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

全球 FINGERS 网络:降低和预防痴呆症风险的全球方法

Kivipelto, Miia; Mangialasche, Francesca; Snyder, Heather M; Allegri, Ricardo; Andrieu, Sandrine; Arai, Hidenori; Baker, Laura; Belleville, Sylvie; Brodaty, Henry; Brucki, Sonia M; Calandri, Ismael; Caramelli, Paulo; Chen, Christopher; Chertkow, Howard; Chew, Effie; Choi, Seong H; Chowdhary, Neerja; Crivelli, Lucía; Torre, Rafael De La; Du, Yifeng; Dua, Tarun; Espeland, Mark; Feldman, Howard H; Hartmanis, Maris; Hartmann, Tobias; Heffernan, Megan; Henry, Christiani J; Hong, Chang H; Håkansson, Krister; Iwatsubo, Takeshi; Jeong, Jee H; Jimenez-Maggiora, Gustavo; Koo, Edward H; Launer, Lenore J; Lehtisalo, Jenni; Lopera, Francisco; Martínez-Lage, Pablo; Martins, Ralph; Middleton, Lefkos; Molinuevo, José L; Montero-Odasso, Manuel; Moon, So Y; Morales-Pérez, Kristal; Nitrini, Ricardo; Nygaard, Haakon B; Park, Yoo K; Peltonen, Markku; Qiu, Chengxuan; Quiroz, Yakeel T; Raman, Rema; Rao, Naren; Ravindranath, Vijayalakshmi; Rosenberg, Anna; Sakurai, Takashi; Salinas, Rosa M; Scheltens, Philip; Sevlever, Gustavo; Soininen, Hilkka; Sosa, Ana L; Suemoto, Claudia K; Tainta-Cuezva, Mikel; Velilla, Lina; Wang, Yongxiang; Whitmer, Rachel; Xu, Xin; Bain, Lisa J; Solomon, Alina; Ngandu, Tiia; Carrillo, Maria C

Transcriptional regulation of APP by apoE: To boldly go where no isoform has gone before: ApoE, APP transcription and AD: Hypothesised mechanisms and existing knowledge gaps

载脂蛋白E对APP的转录调控:大胆探索前所未有的领域:载脂蛋白E、APP转录与阿尔茨海默病:假说机制与现有知识空白

Lee, Liying Corinne; Goh, Michele Q L; Koo, Edward H

Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology

淀粉样蛋白积累驱动阿尔茨海默病样病理小鼠模型中蛋白质组的广泛改变

Savas, Jeffrey N; Wang, Yi-Zhi; DeNardo, Laura A; Martinez-Bartolome, Salvador; McClatchy, Daniel B; Hark, Timothy J; Shanks, Natalie F; Cozzolino, Kira A; Lavallée-Adam, Mathieu; Smukowski, Samuel N; Park, Sung Kyu; Kelly, Jeffery W; Koo, Edward H; Nakagawa, Terunaga; Masliah, Eliezer; Ghosh, Anirvan; Yates, John R 3rd

Rarity of the Alzheimer disease-protective APP A673T variant in the United States

美国罕见的具有阿尔茨海默病保护作用的APP A673T变异体

Wang, Li-San; Naj, Adam C; Graham, Robert R; Crane, Paul K; Kunkle, Brian W; Cruchaga, Carlos; Murcia, Josue D Gonzalez; Cannon-Albright, Lisa; Baldwin, Clinton T; Zetterberg, Henrik; Blennow, Kaj; Kukull, Walter A; Faber, Kelley M; Schupf, Nicole; Norton, Maria C; Tschanz, JoAnn T; Munger, Ronald G; Corcoran, Christopher D; Rogaeva, Ekaterina; Lin, Chiao-Feng; Dombroski, Beth A; Cantwell, Laura B; Partch, Amanda; Valladares, Otto; Hakonarson, Hakon; St George-Hyslop, Peter; Green, Robert C; Goate, Alison M; Foroud, Tatiana M; Carney, Regina M; Larson, Eric B; Behrens, Timothy W; Kauwe, John S K; Haines, Jonathan L; Farrer, Lindsay A; Pericak-Vance, Margaret A; Mayeux, Richard; Schellenberg, Gerard D; Albert, Marilyn S; Albin, Roger L; Apostolova, Liana G; Arnold, Steven E; Barber, Robert; Barmada, Michael; Barnes, Lisa L; Beach, Thomas G; Becker, James T; Beecham, Gary W; Beekly, Duane; Bennett, David A; Bigio, Eileen H; Bird, Thomas D; Blacker, Deborah; Boeve, Bradley F; Bowen, James D; Boxer, Adam; Burke, James R; Buxbaum, Joseph D; Cairns, Nigel J; Cao, Chuanhai; Carlson, Chris S; Carroll, Steven L; Chui, Helena C; Clark, David G; Cribbs, David H; Crocco, Elizabeth A; DeCarli, Charles; DeKosky, Steven T; Demirci, F Yesim; Dick, Malcolm; Dickson, Dennis W; Duara, Ranjan; Ertekin-Taner, Nilufer; Fallon, Kenneth B; Farlow, Martin R; Ferris, Steven; Frosch, Matthew P; Galasko, Douglas R; Ganguli, Mary; Gearing, Marla; Geschwind, Daniel H; Ghetti, Bernardino; Gilbert, John R; Glass, Jonathan D; Graff-Radford, Neill R; Growdon, John H; Hamilton, Ronald L; Hamilton-Nelson, Kara L; Harrell, Lindy E; Head, Elizabeth; Honig, Lawrence S; Hulette, Christine M; Hyman, Bradley T; Jarvik, Gail P; Jicha, Gregory A; Jin, Lee-Way; Jun, Gyungah; Jun, Gyungah; Kamboh, M Ilyas; Karydas, Anna; Kaye, Jeffrey A; Kim, Ronald; Koo, Edward H; Kowall, Neil W; Kramer, Joel H; LaFerla, Frank M; Lah, James J; Leverenz, James B; Levey, Allan I; Li, Gei; Lieberman, Andrew P; Lopez, Oscar L; Lunetta, Kathryn L; Lyketsos, Constantine G; Mack, Wendy J; Marson, Daniel C; Martin, Eden R; Martiniuk, Frank; Mash, Deborah C; Masliah, Eliezer; McCormick, Wayne C; McCurry, Susan M; McDavid, Andrew N; McKee, Ann C; Mesulam, W Marsel; Miller, Bruce L; Miller, Carol A; Miller, Joshua W; Montine, Thomas J; Morris, John C; Murrell, Jill R; Olichney, John M; Parisi, Joseph E; Perry, William; Peskind, Elaine; Petersen, Ronald C; Pierce, Aimee; Poon, Wayne W; Potter, Huntington; Quinn, Joseph F; Raj, Ashok; Raskind, Murray; Reiman, Eric M; Reisberg, Barry; Reitz, Christiane; Ringman, John M; Roberson, Erik D; Rosen, Howard J; Rosenberg, Roger N; Sano, Mary; Saykin, Andrew J; Schneider, Julie A; Schneider, Lon S; Seeley, William W; Smith, Amanda G; Sonnen, Joshua A; Spina, Salvatore; Stern, Robert A; Tanzi, Rudolph E; Thornton-Wells, Tricia A; Trojanowski, John Q; Troncoso, Juan C; Tsuang, Debby W; Van Deerlin, Vivianna M; Van Eldik, Linda J; Vardarajan, Badri N; Vinters, Harry V; Vonsattel, Jean Paul; Weintraub, Sandra; Welsh-Bohmer, Kathleen A; Williamson, Jennifer; Wishnek, Sarah; Woltjer, Randall L; Wright, Clinton B; Younkin, Steven G; Yu, Chang-En; Yu, Lei

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

淀粉样前体蛋白及其蛋白水解片段的多面性:亦敌亦友

Nhan, Hoang S; Chiang, Karen; Koo, Edward H

Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans

γ-分泌酶调节剂对灵长类动物和人类体内Aβ42的调节作用

Ling, I-Fang; Golde, Todd E; Galasko, Douglas R; Koo, Edward H

Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP

唐氏综合征认知功能障碍、血管生物学和阿尔茨海默病痴呆症背后的相互依赖机制:APP的多重作用

Nizetic, Dean; Chen, Christopher L; Hong, Wanjin; Koo, Edward H

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

多个基因位点对晚发性阿尔茨海默病发病年龄的影响:一项全基因组关联研究

Naj, Adam C; Jun, Gyungah; Reitz, Christiane; Kunkle, Brian W; Perry, William; Park, Yo Son; Beecham, Gary W; Rajbhandary, Ruchita A; Hamilton-Nelson, Kara L; Wang, Li-San; Kauwe, John S K; Huentelman, Matthew J; Myers, Amanda J; Bird, Thomas D; Boeve, Bradley F; Baldwin, Clinton T; Jarvik, Gail P; Crane, Paul K; Rogaeva, Ekaterina; Barmada, M Michael; Demirci, F Yesim; Cruchaga, Carlos; Kramer, Patricia L; Ertekin-Taner, Nilufer; Hardy, John; Graff-Radford, Neill R; Green, Robert C; Larson, Eric B; St George-Hyslop, Peter H; Buxbaum, Joseph D; Evans, Denis A; Schneider, Julie A; Lunetta, Kathryn L; Kamboh, M Ilyas; Saykin, Andrew J; Reiman, Eric M; De Jager, Philip L; Bennett, David A; Morris, John C; Montine, Thomas J; Goate, Alison M; Blacker, Deborah; Tsuang, Debby W; Hakonarson, Hakon; Kukull, Walter A; Foroud, Tatiana M; Martin, Eden R; Haines, Jonathan L; Mayeux, Richard P; Farrer, Lindsay A; Schellenberg, Gerard D; Pericak-Vance, Margaret A; Albert, Marilyn S; Albin, Roger L; Apostolova, Liana G; Arnold, Steven E; Barber, Robert; Barnes, Lisa L; Beach, Thomas G; Becker, James T; Beekly, Duane; Bigio, Eileen H; Bowen, James D; Boxer, Adam; Burke, James R; Cairns, Nigel J; Cantwell, Laura B; Cao, Chuanhai; Carlson, Chris S; Carney, Regina M; Carrasquillo, Minerva M; Carroll, Steven L; Chui, Helena C; Clark, David G; Corneveaux, Jason; Cribbs, David H; Crocco, Elizabeth A; DeCarli, Charles; DeKosky, Steven T; Dick, Malcolm; Dickson, Dennis W; Duara, Ranjan; Faber, Kelley M; Fallon, Kenneth B; Farlow, Martin R; Ferris, Steven; Frosch, Matthew P; Galasko, Douglas R; Ganguli, Mary; Gearing, Marla; Geschwind, Daniel H; Ghetti, Bernardino; Gilbert, John R; Glass, Jonathan D; Growdon, John H; Hamilton, Ronald L; Harrell, Lindy E; Head, Elizabeth; Honig, Lawrence S; Hulette, Christine M; Hyman, Bradley T; Jicha, Gregory A; Jin, Lee-Way; Karydas, Anna; Kaye, Jeffrey A; Kim, Ronald; Koo, Edward H; Kowall, Neil W; Kramer, Joel H; LaFerla, Frank M; Lah, James J; Leverenz, James B; Levey, Allan I; Li, Ge; Lieberman, Andrew P; Lin, Chiao-Feng; Lopez, Oscar L; Lyketsos, Constantine G; Mack, Wendy J; Martiniuk, Frank; Mash, Deborah C; Masliah, Eliezer; McCormick, Wayne C; McCurry, Susan M; McDavid, Andrew N; McKee, Ann C; Mesulam, Marsel; Miller, Bruce L; Miller, Carol A; Miller, Joshua W; Murrell, Jill R; Olichney, John M; Pankratz, Vernon S; Parisi, Joseph E; Paulson, Henry L; Peskind, Elaine; Petersen, Ronald C; Pierce, Aimee; Poon, Wayne W; Potter, Huntington; Quinn, Joseph F; Raj, Ashok; Raskind, Murray; Reisberg, Barry; Ringman, John M; Roberson, Erik D; Rosen, Howard J; Rosenberg, Roger N; Sano, Mary; Schneider, Lon S; Seeley, William W; Smith, Amanda G; Sonnen, Joshua A; Spina, Salvatore; Stern, Robert A; Tanzi, Rudolph E; Thornton-Wells, Tricia A; Trojanowski, John Q; Troncoso, Juan C; Valladares, Otto; Van Deerlin, Vivianna M; Van Eldik, Linda J; Vardarajan, Badri N; Vinters, Harry V; Vonsattel, Jean Paul; Weintraub, Sandra; Welsh-Bohmer, Kathleen A; Williamson, Jennifer; Wishnek, Sarah; Woltjer, Randall L; Wright, Clinton B; Younkin, Steven G; Yu, Chang-En; Yu, Lei