Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene
通过结构鉴定,确定 RyR1 的 RY12 结构域为 ADP 传感器,并且是恶性高热疗法药物丹曲林的靶点。
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doi:10.1101/2024.10.21.619409
Kim, Kookjoo; Li, Huan; Yuan, Qi; Melville, Zephan; Zalk, Ran; des Georges, Amédée; Frank, Joachim; Hendrickson, Wayne A; Marks, Andrew R; Clarke, Oliver B