文献库，生知库 | 链接生命科学的每一步

Thapa, Aayusha; Nallapu, Aasritha; Mougboh, Nnenna; Nedunchezian, Swathi; Talati, Khushi; Yang, Brian; Hyun, Jungheun; Sanchez, John Michael; Seet, Christopher S; Koon, Hon Wai; Li, Zhaoping; Ciorba, Matthew A; Michelsen, Kathrin; Kulkarni, Hrishikesh S; Kulkarni, Devesha H

结肠炎

肠炎

免疫/内分泌

发表日期：2026

文献求助收藏

Fidaxomicin Reduces Collagen Expression in Intestinal Fibroblasts Via Platelet-Derived Growth Factor Receptor Beta and Glycogen Synthase Kinase-3 Beta Inhibition

菲达霉素通过抑制血小板衍生生长因子受体β和糖原合成酶激酶-3β来降低肠道成纤维细胞中的胶原蛋白表达

期刊:Gastroenterology

影响因子:25.1

doi:10.1053/j.gastro.2025.04.028

Irwin, Sophie; van Daelen, Mieke; Almaraz, Isabella; Park, Rebecca; Nelson, Becca; Mahurkar-Joshi, Swapna; Rieder, Florian; Shih, David Q; Ho, Wendy; Limketkai, Berkeley; Koon, Hon Wai

Citrulline Inhibits Clostridioides difficile Infection With Anti-inflammatory Effects.

瓜氨酸通过抗炎作用抑制艰难梭菌感染

期刊:Cellular and Molecular Gastroenterology and Hepatology

影响因子:7.4

doi:10.1016/j.jcmgh.2025.101474

Xie Ying, Irwin Sophie, Nelson Becca, van Daelen Mieke, Fontenot Lindsey, Jacobs Jonathan P, Cappelletti Monica, Feng Hanping, Li Yiling, Koon Hon Wai

MicroRNA Sequencing of Serum Exosomes Reveals miR205-5p as an Anti-Fibrogenic Factor Against Intestinal Fibrosis in Crohn's Disease.

血清外泌体微RNA测序揭示miR205-5p是克罗恩病肠道纤维化的抗纤维化因子

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms26083778

Xie Ying, van Daelen Mieke, Park Rebecca, Almaraz Isabella, Fontenot Lindsey, Rieder Florian, Ho Wendy, Limketkai Berkeley, Shih David Q, Wei Minjie, Li Yiling, Koon Hon Wai

Loratadine as an Anti-inflammatory Agent Against Clostridium difficile Toxin B

氯雷他定作为一种抗炎药，可用于治疗艰难梭菌毒素B感染。

期刊:Journal of Infectious Diseases

影响因子:4.5

doi:10.1093/infdis/jiae021

Xie, Ying; Irwin, Sophie; Chupina Estrada, Andrea; Nelson, Becca; Bullock, Ashlen; Fontenot, Lindsey; Feng, Hanping; Sun, Mingjun; Koon, Hon Wai

炎症/感染

发表日期：2024

文献求助收藏

Genistein Inhibits Clostridioides difficile Infection via Estrogen Receptors and Lysine-Deficient Protein Kinase 1

染料木素通过雌激素受体和赖氨酸缺乏蛋白激酶1抑制艰难梭菌感染

期刊:Journal of Infectious Diseases

影响因子:4.5

doi:10.1093/infdis/jiad008

Xie, Ying; Fontenot, Lindsey; Estrada, Andrea Chupina; Nelson, Becca; Bullock, Ashlen; Faull, Kym F; Feng, Hanping; Sun, Mingjun; Koon, Hon Wai

Mice expressing fluorescent PAR(2) reveal that endocytosis mediates colonic inflammation and pain

表达荧光PAR(2)的小鼠表明，内吞作用介导结肠炎症和疼痛。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2112059119

Latorre, Rocco; Hegron, Alan; Peach, Chloe J; Teng, Shavonne; Tonello, Raquel; Retamal, Jeffri S; Klein-Cloud, Rafael; Bok, Diana; Jensen, Dane D; Gottesman-Katz, Lena; Rientjes, Jeanette; Veldhuis, Nicholas A; Poole, Daniel P; Schmidt, Brian L; Pothoulakis, Charalabos H; Rankin, Carl; Xie, Ying; Koon, Hon Wai; Bunnett, Nigel W

Therapeutic Mechanism of Macrophage Inflammatory Protein 1 α Neutralizing Antibody (CCL3) in Clostridium difficile Infection in Mice

巨噬细胞炎症蛋白1α中和抗体（CCL3）在小鼠艰难梭菌感染中的治疗机制

期刊:Journal of Infectious Diseases

影响因子:4.5

doi:10.1093/infdis/jiz640

Wang, Jiani; Ortiz, Christina; Fontenot, Lindsey; Mukhopadhyay, Riya; Xie, Ying; Chen, Xinhua; Feng, Hanping; Pothoulakis, Charalabos; Koon, Hon Wai

Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohn's disease, and clinical prognosis in inflammatory bowel disease

循环抗菌肽水平与溃疡性结肠炎的黏膜疾病活动度、克罗恩病的肠道狭窄风险以及炎症性肠病的临床预后相关。

期刊:BMC Gastroenterology

影响因子:2.6

doi:10.1186/s12876-017-0619-4

Tran, Diana Hoang-Ngoc; Wang, Jiani; Ha, Christina; Ho, Wendy; Mattai, S Anjani; Oikonomopoulos, Angelos; Weiss, Guy; Lacey, Precious; Cheng, Michelle; Shieh, Christine; Mussatto, Caroline C; Ho, Samantha; Hommes, Daniel; Koon, Hon Wai

Antimicrobial peptides and colitis

抗菌肽与结肠炎

期刊:Current Pharmaceutical Design

影响因子:2.8

doi:10.2174/13816128130108

Ho, Samantha; Pothoulakis, Charalabos; Koon, Hon Wai

Mucosally sourced complement factor B modulates the host response to colitis

黏膜来源的补体因子B调节宿主对结肠炎的反应

Fidaxomicin Reduces Collagen Expression in Intestinal Fibroblasts Via Platelet-Derived Growth Factor Receptor Beta and Glycogen Synthase Kinase-3 Beta Inhibition

菲达霉素通过抑制血小板衍生生长因子受体β和糖原合成酶激酶-3β来降低肠道成纤维细胞中的胶原蛋白表达

Citrulline Inhibits Clostridioides difficile Infection With Anti-inflammatory Effects.

瓜氨酸通过抗炎作用抑制艰难梭菌感染

MicroRNA Sequencing of Serum Exosomes Reveals miR205-5p as an Anti-Fibrogenic Factor Against Intestinal Fibrosis in Crohn's Disease.

血清外泌体微RNA测序揭示miR205-5p是克罗恩病肠道纤维化的抗纤维化因子

Loratadine as an Anti-inflammatory Agent Against Clostridium difficile Toxin B

氯雷他定作为一种抗炎药，可用于治疗艰难梭菌毒素B感染。

Genistein Inhibits Clostridioides difficile Infection via Estrogen Receptors and Lysine-Deficient Protein Kinase 1

染料木素通过雌激素受体和赖氨酸缺乏蛋白激酶1抑制艰难梭菌感染

Mice expressing fluorescent PAR(2) reveal that endocytosis mediates colonic inflammation and pain

表达荧光PAR(2)的小鼠表明，内吞作用介导结肠炎症和疼痛。

Therapeutic Mechanism of Macrophage Inflammatory Protein 1 α Neutralizing Antibody (CCL3) in Clostridium difficile Infection in Mice

巨噬细胞炎症蛋白1α中和抗体（CCL3）在小鼠艰难梭菌感染中的治疗机制

Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohn's disease, and clinical prognosis in inflammatory bowel disease

循环抗菌肽水平与溃疡性结肠炎的黏膜疾病活动度、克罗恩病的肠道狭窄风险以及炎症性肠病的临床预后相关。

Antimicrobial peptides and colitis

抗菌肽与结肠炎