Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites.
利用 Ca2+ 成像分析法,通过人类干细胞衍生的心肌细胞评估药物引起的 QT 间期延长和致心律失常风险:在三个测试点对 28 种 CiPA 化合物进行评估
期刊:Toxicological Sciences
影响因子:4.1
doi:10.1093/toxsci/kfz102
Lu Hua Rong, Zeng Haoyu, Kettenhofen Ralf, Guo Liang, Kopljar Ivan, van Ammel Karel, Tekle Fetene, Teisman Ard, Zhai Jin, Clouse Holly, Pierson Jennifer, Furniss Michael, Lagrutta Armando, Sannajust Frederick, Gallacher David J