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Report of the Advanced Prostate Cancer Consensus Conference-JAPAN 2025 at the 112(th) Annual Meeting of the Japanese Urological Association

日本泌尿外科协会第112届年会上关于晚期前列腺癌共识会议——JAPAN 2025的报告

期刊:Translational Andrology and Urology

影响因子:1.7

doi:10.21037/tau-2025-709

Inoue, Takahiro; Kosaka, Takeo; Kato, Masashi; Yokomizo, Akira; Eto, Masatoshi; Hara, Isao; Suzuki, Hiroyoshi

A Case of Testicular Malakoplakia With Markedly High Signal Intensity on Fat-Suppressed T1-Weighted Images

一例睾丸软斑病，脂肪抑制T1加权像上信号强度显著增高

期刊:IJU Case Reports

影响因子:0.6

doi:10.1002/iju5.70187

Yagi, Fumiko; Akita, Hirotaka; Kosaka, Takeo; Ueno, Akihisa; Kotera, Teppei; Kobayashi, Masato; Mekada, Hideaki; Oya, Mototsugu; Jinzaki, Masahiro

信号转导

发表日期：2026

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Incidentally Detected Ductal Adenocarcinoma Presenting With Isolated Pulmonary Metastasis and a BRCA2 Mutation

偶然发现的导管腺癌伴孤立性肺转移和 BRCA2 突变

期刊:IJU Case Reports

影响因子:0.6

doi:10.1002/iju5.70103

Karasawa, Hiroyuki; Kosaka, Takeo; Komatsuda, Akari; Baba, Yuto; Nakamura, Kohei; Nishihara, Hiroshi; Oya, Mototsugu

Drastic Response to Olaparib in a Patient With Metastatic Castration-Resistant Prostate Cancer Harboring BRCA2 Alterations and Near-Threshold Tumor Mutational Burden

奥拉帕尼治疗对携带 BRCA2 突变且肿瘤突变负荷接近阈值的转移性去势抵抗性前列腺癌患者产生了显著疗效

期刊:IJU Case Reports

影响因子:0.6

doi:10.1002/iju5.70144

Yokota, Kotaro; Kosaka, Takeo; Daimon, Tatsuaki; Fujiwara, Shinnosuke; Nakamura, Kohei; Nishihara, Hiroshi; Oya, Mototsugu

Safety and Efficacy of Tarlatamab in Patients with Neuroendocrine Prostate Cancer: Results from the Phase 1b DeLLpro-300 Study

Tarlatamab治疗神经内分泌性前列腺癌患者的安全性和有效性：来自1b期DeLLpro-300研究的结果

期刊:Clinical Cancer Research

影响因子:10.2

doi:10.1158/1078-0432.CCR-25-1211

Aggarwal, Rahul; Rottey, Sylvie; Bernard-Tessier, Alice; Mellado, Begoña; Kosaka, Takeo; Stadler, Walter M; Horvath, Lisa; Greil, Richard; O'Neil, Bert; Siddiqui, Bilal A; Bauernhofer, Thomas; Bilen, Mehmet A; Eskens, Ferry; Sandhu, Shahneen; Shaw, Crystal; Ju, Chia Hsin; Decato, Benjamin E; Yu, Brian; Aparicio, Ana

MUC1-C dependence in treatment-resistant prostate cancer uncovers a target for antibody-drug conjugate therapy.

MUC1-C 在耐药性前列腺癌中的依赖性揭示了抗体药物偶联疗法的靶点

期刊:JCI Insight

影响因子:6.1

doi:10.1172/jci.insight.190924

Shigeta Keisuke, Daimon Tatsuaki, Hongo Hiroshi, Ku Sheng-Yu, Ozawa Hiroki, Haratake Naoki, Fushimi Atsushi, Nakashoji Ayako, Bhattacharya Atrayee, Takamori Shinkichi, Kono Michihisa, Rokugo Masahiro, Baba Yuto, Kosaka Takeo, Oya Mototsugu, Jacobi Justine, Long Mark D, Beltran Himisha, Kufe Donald

Phase 3 Study of Talazoparib Plus Enzalutamide Versus Placebo Plus Enzalutamide as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer: TALAPRO-2 Japanese Subgroup Analysis

一项评估他拉唑帕尼联合恩扎卢胺与安慰剂联合恩扎卢胺作为转移性去势抵抗性前列腺癌一线治疗方案的3期研究：TALAPRO-2日本亚组分析

期刊:Cancer Medicine

影响因子:3.1

doi:10.1002/cam4.70333

Matsubara, Nobuaki; Miyake, Hideaki; Uemura, Hiroji; Mizokami, Atsushi; Kikukawa, Hiroaki; Kosaka, Takeo; Nishimura, Kazuo; Nakamura, Motonobu; Kobayashi, Kazuki; Komaru, Atsushi; Mori, Yuko; Toyoizumi, Shigeyuki; Hori, Natsuki; Umeyama, Yoshiko; Uemura, Hirotsugu

Dynamics in the Prostate Immune Microenvironment Induced by Androgen Deprivation Therapy

雄激素剥夺疗法诱导的前列腺免疫微环境动态变化

期刊:Prostate

影响因子:2.5

doi:10.1002/pros.24828

Yanai, Yoshinori; Kosaka, Takeo; Mikami, Shuji; Arai, Masashi; Watanabe, Keitaro; Takeda, Toshikazu; Matsumoto, Kazuhiro; Yamashita, Makiko; Kitano, Shigehisa; Oya, Mototsugu

免疫/内分泌

发表日期：2025

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Loss of phosphatase and tensin homolog expression castration-sensitive prostate cancer predicts outcomes in men after prostatectomy

磷酸酶和张力蛋白同源物表达缺失的去势敏感性前列腺癌可预测前列腺切除术后男性的预后

期刊:International Journal of Urology

影响因子:2.2

doi:10.1111/iju.15592

Yanai, Yoshinori; Mikami, Shuji; Yasumizu, Yota; Takeda, Toshikazu; Matsumoto, Kazuhiro; Kitano, Shigehisa; Oya, Mototsugu; Kosaka, Takeo

Revisiting the impact of BRCA1 pathogenic variants on the aggressiveness of prostate cancer

重新审视BRCA1致病变异对前列腺癌侵袭性的影响

Report of the Advanced Prostate Cancer Consensus Conference-JAPAN 2025 at the 112(th) Annual Meeting of the Japanese Urological Association

日本泌尿外科协会第112届年会上关于晚期前列腺癌共识会议——JAPAN 2025的报告

A Case of Testicular Malakoplakia With Markedly High Signal Intensity on Fat-Suppressed T1-Weighted Images

一例睾丸软斑病，脂肪抑制T1加权像上信号强度显著增高

Incidentally Detected Ductal Adenocarcinoma Presenting With Isolated Pulmonary Metastasis and a BRCA2 Mutation

偶然发现的导管腺癌伴孤立性肺转移和 BRCA2 突变

Drastic Response to Olaparib in a Patient With Metastatic Castration-Resistant Prostate Cancer Harboring BRCA2 Alterations and Near-Threshold Tumor Mutational Burden

奥拉帕尼治疗对携带 BRCA2 突变且肿瘤突变负荷接近阈值的转移性去势抵抗性前列腺癌患者产生了显著疗效

Safety and Efficacy of Tarlatamab in Patients with Neuroendocrine Prostate Cancer: Results from the Phase 1b DeLLpro-300 Study

Tarlatamab治疗神经内分泌性前列腺癌患者的安全性和有效性：来自1b期DeLLpro-300研究的结果

MUC1-C dependence in treatment-resistant prostate cancer uncovers a target for antibody-drug conjugate therapy.

MUC1-C 在耐药性前列腺癌中的依赖性揭示了抗体药物偶联疗法的靶点

Phase 3 Study of Talazoparib Plus Enzalutamide Versus Placebo Plus Enzalutamide as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer: TALAPRO-2 Japanese Subgroup Analysis

一项评估他拉唑帕尼联合恩扎卢胺与安慰剂联合恩扎卢胺作为转移性去势抵抗性前列腺癌一线治疗方案的3期研究：TALAPRO-2日本亚组分析

Dynamics in the Prostate Immune Microenvironment Induced by Androgen Deprivation Therapy

雄激素剥夺疗法诱导的前列腺免疫微环境动态变化

Loss of phosphatase and tensin homolog expression castration-sensitive prostate cancer predicts outcomes in men after prostatectomy

磷酸酶和张力蛋白同源物表达缺失的去势敏感性前列腺癌可预测前列腺切除术后男性的预后