日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing

利用 CRISPR/dCas9 介导的表观基因组编辑技术对 Fgf21 启动子进行靶向 DNA 去甲基化。

Nozomi Hanzawa ,Koshi Hashimoto ,Xunmei Yuan ,Kenichi Kawahori ,Kazutaka Tsujimoto ,Miho Hamaguchi ,Toshiya Tanaka ,Yuya Nagaoka ,Hiroshi Nishina ,Sumiyo Morita ,Izuho Hatada ,Tetsuya Yamada ,Yoshihiro Ogawa

Severe Non-Islet Cell Hypoglycemia From Ileum-Origin Gastrointestinal Stromal Tumor Producing Insulin-Like Growth Factor-2 in a Patient With Liver Cirrhosis Due to Chronic Hepatitis B

慢性乙型肝炎导致肝硬化患者回肠源性胃肠道间质瘤产生胰岛素样生长因子-2,导致严重非胰岛细胞低血糖症

Kohzo Takebayashi, Sho Furukawa, Takenori Okumura, Mio Kubo, Atsushi Ujiie, Mototaka Yamauchi, Hiroyuki Shinozaki, Kenji Hara, Takafumi Tsuchiya, Yuko Ono, Toshihiko Inukai, Koshi Hashimoto

Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

围产期小鼠肝脏中 Fgf21 的表观遗传调节可改善成年期饮食引起的肥胖

Xunmei Yuan, Kazutaka Tsujimoto, Koshi Hashimoto, Kenichi Kawahori, Nozomi Hanzawa, Miho Hamaguchi, Takami Seki, Makiko Nawa, Tatsuya Ehara, Yohei Kitamura, Izuho Hatada, Morichika Konishi, Nobuyuki Itoh, Yoshimi Nakagawa, Hitoshi Shimano, Takako Takai-Igarashi, Yasutomi Kamei, Yoshihiro Ogawa

Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress

宫内营养不良引发食用致肥饮食的成年小鼠后代肝脂肪变性;涉及内质网应激

Keiko Muramatsu-Kato, Hiroaki Itoh, Yukiko Kohmura-Kobayashi, Urmi J Ferdous, Naoaki Tamura, Chizuko Yaguchi, Toshiyuki Uchida, Kazunao Suzuki, Koshi Hashimoto, Takayoshi Suganami, Yoshihiro Ogawa, Naohiro Kanayama

Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor

由于肝脏瘦素受体表达增强,Helz2 缺陷雄性小鼠可免受高脂饮食引起的肥胖症

Satoshi Yoshino, Tetsurou Satoh, Masanobu Yamada, Koshi Hashimoto, Takuya Tomaru, Akiko Katano-Toki, Satoru Kakizaki, Shuichi Okada, Hiroyuki Shimizu, Atsushi Ozawa, Takafumi Tuchiya, Hayato Ikota, Yoichi Nakazato, Munemasa Mori, Takashi Matozaki, Tsutomu Sasaki, Tadahiro Kitamura, Masatomo Mori

Crosstalk between thyroid hormone receptor and liver X receptor in the regulation of selective Alzheimer's disease indicator-1 gene expression

甲状腺激素受体和肝脏X受体之间的串扰在选择性阿尔茨海默病指标-1基因表达的调节中

Emi Ishida, Koshi Hashimoto, Shuichi Okada, Tetsurou Satoh, Masanobu Yamada, Masatomo Mori

Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line

Nesfatin-1 诱导 cAMP 反应元件结合蛋白的磷酸化水平,从而促进神经细胞系中的细胞内信号传导

Emi Ishida, Koshi Hashimoto, Hiroyuki Shimizu, Shuichi Okada, Tetsurou Satoh, Ikuo Kato, Masanobu Yamada, Masatomo Mori

NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice

NR4A1(Nur77)介导促甲状腺激素释放激素诱导的促甲状腺激素β基因转录刺激:TRH基因敲除小鼠分析

Yasuyo Nakajima, Masanobu Yamada, Ryo Taguchi, Nobuyuki Shibusawa, Atsushi Ozawa, Takuya Tomaru, Koshi Hashimoto, Tsugumichi Saito, Takafumi Tsuchiya, Shuichi Okada, Tetsurou Satoh, Masatomo Mori

Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone

碳水化合物反应元件结合蛋白基因表达受甲状腺激素正向调控

Koshi Hashimoto, Emi Ishida, Shunichi Matsumoto, Shuichi Okada, Masanobu Yamada, Teturou Satoh, Tsuyoshi Monden, Masatomo Mori

Aberrant histone modifications at the thyrotropin-releasing hormone gene in resistance to thyroid hormone: analysis of F455S mutant thyroid hormone receptor

促甲状腺激素释放激素基因异常组蛋白修饰导致甲状腺激素抵抗:F455S 突变甲状腺激素受体分析

Ryohei Umezawa, Masanobu Yamada, Kazuhiko Horiguchi, Sumiyasu Ishii, Koshi Hashimoto, Shuichi Okada, Teturou Satoh, Masatomo Mori