日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides

针对肝脏靶向的桥联核酸反义寡核苷酸的药物发现和开发方案

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.1
doi:10.1016/j.omtn.2021.10.008
Wada, Fumito; Yamamoto, Tsuyoshi; Kobayashi, Tadayuki; Tachibana, Keisuke; Ito, Kosuke Ramon; Hamasaki, Mayumi; Kayaba, Yukina; Terada, Chisato; Yamayoshi, Asako; Obika, Satoshi; Harada-Shiba, Mariko
发表日期：2021
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Cleavage of oligonucleotides containing a P3'→N5' phosphoramidate linkage mediated by single-stranded oligonucleotide templates

由单链寡核苷酸模板介导的含有 P3'→N5' 磷酰胺键的寡核苷酸的裂解

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules161210695
Ito, Kosuke Ramon; Kodama, Tetsuya; Makimura, Futaba; Hosoki, Noritsugu; Osaki, Tomohisa; Orita, Ayako; Imanishi, Takeshi; Obika, Satoshi
发表日期：2011
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Double-stranded DNA-templated cleavage of oligonucleotides containing a P3'->N5' linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity

以双链DNA为模板，通过三链体形成触发含有P3'->N5'连接的寡核苷酸的切割：化学修饰的影响及反应活性的显著增强

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkq600
Ito, Kosuke Ramon; Kodama, Tetsuya; Tomizu, Masaharu; Negoro, Yoshinori; Orita, Ayako; Osaki, Tomohisa; Hosoki, Noritsugu; Tanaka, Takaya; Imanishi, Takeshi; Obika, Satoshi
发表日期：2010
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